7-nitro-1H-indole-2-carbohydrazide | 90886-84-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 7-nitro-1H-indole-2-carbohydrazide
• 英文别名: 7-nitroindole-2-carbohydrazide；7-nitro-indole-2-carboxylic acid hydrazide
• CAS: 90886-84-3
• 化学式: C₉H₈N₄O₃
• 分子量: 220.188
• InChiKey: WHKUANUVGNDTFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  117
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  7-nitro-1H-indole-2-carbohydrazide 在 溶剂黄146 、 sodium nitrite 作用下， 以 1,4-二氧六环 、 水 为溶剂， 以95%的产率得到7-Nitro-1H-indole-2-carbonyl azide
  参考文献：
  名称：

  Design, synthesis, and biological evaluation of novel trifluoromethyl indoles as potent HIV-1 NNRTIs with an improved drug resistance profile

  摘要：

  一系列三氟甲基吲哚类化合物已被设计、合成并进行了抗HIV-1活性评价。

  DOI：

  10.1039/c3ob42186d
• 作为产物：
  描述：

  7-硝基-1H-吲哚-2-羧酸甲酯 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 5.0h， 以95%的产率得到7-nitro-1H-indole-2-carbohydrazide
  参考文献：
  名称：

  Design, synthesis, and biological evaluation of novel trifluoromethyl indoles as potent HIV-1 NNRTIs with an improved drug resistance profile

  摘要：

  一系列三氟甲基吲哚类化合物已被设计、合成并进行了抗HIV-1活性评价。

  DOI：

  10.1039/c3ob42186d

文献信息

• Substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benzopyrans
  申请人：——

  公开号：US20020193410A1

  公开（公告）日：2002-12-19

  This invention is directed to substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benzopyrans that inhibit Factor Xa, pharmaceutical compositions comprising these compounds and their use for inhibiting Factor Xa or treating pathological conditions in a patient that may be ameliorated by administration of such compounds. This invention is also is also directed to substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benzopyrans which directly inhibit both Factor Xa and Factor IIa (thrombin), to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these compounds and to a method of simultaneously directly inhibiting both Factor Xa and Factor IIa (thrombin).

  这项发明涉及取代的（氨基亚甲基或氨甲基）二氢苯并呋喃和苯并吡喃，这些化合物抑制因子Xa，包括这些化合物的药物组合物以及它们用于抑制因子Xa或治疗可以通过给予这些化合物改善的患者的病理状况。这项发明还涉及取代的（氨基亚甲基或氨甲基）二氢苯并呋喃和苯并吡喃，直接抑制因子Xa和因子IIa（凝血酶），包括这些化合物的药物组合物，用于制备这些化合物的中间体，以及同时直接抑制因子Xa和因子IIa（凝血酶）的方法。
• Condensation of 7-Nitroindole-2-carbohydrazide Derivatives with Ethyl Acetoacetate
  作者：Abdellatif El-Kihel、Amal Erroussafi、Mustapha Ahbala、Salaheddine Guesmi、Patrick Bauchat

  DOI：10.14233/ajchem.2016.19693

  日期：——

  Pyrazolylindolyl ketone derivatives were obtained by cyclization of the condensation products 7-nitroindole-2-carbohydrazide derivatives with ethyl acetoacetate. We have shown careful examination of spectroscopic data and the open-chain intermediate isolation as well as the identification of the formed compound structure.

  吡唑啉酮衍生物是通过将缩合产物7-硝基吲哚-2-甲酰肼衍生物与乙酰乙酸乙酯进行环化反应而获得的。我们仔细研究了光谱数据，分离了开链中间体，并确定了所形成的化合物结构。
• Synthesis of some new biologically active 1,3,4-oxadiazolyl nitroindoles and a modified Fischer indole synthesis of ethyl nitro indole-2-carboxylates
  作者：B. Narayana、B.V. Ashalatha、K.K. Vijaya Raj、J. Fernandes、B.K. Sarojini

  DOI：10.1016/j.bmc.2005.04.068

  日期：2005.8

  An efficient and modified synthesis of ethyl-4-nitro/5-nitro/6-nitro and 7-nitroindole-2-carboxylates is described. Carbo-hydrazides of corresponding ethyl nitroindole-2-carboxylates underwent smooth one-step transformation to 1,3,4-oxadiazolyl nitroindoles (4a-I) on reaction with aromatic carboxylic acids in the presence of phosphorus oxychloride. An alternate method to synthesize 1,3,4-oxadiazolyl nitroindoles is also described. Among the newly synthesized 1,3,4-oxadiazolyl nitroindoles, a few compounds are studied for anti-inflammatory activity. (c) 2005 Published by Elsevier Ltd.
• Narayana; Ashalatha; Vijaya Raj, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009, vol. 48, # 12, p. 1794 - 1805
  作者：Narayana、Ashalatha、Vijaya Raj、Sarojini

  DOI：——

  日期：——
• Synthesis and Biological Activity of Novel 4-/5-/6-/7-Nitro-<i>N</i> ′-(4-Aryl-1,3-Thiazol-2-yl)1<i>H</i>-Indole-2-Carbohydrazide Derivatives
  作者：B. V. Ashalatha、B. Narayana、N. Suchetha Kumari

  DOI：10.1080/10426500600864684

  日期：2006.12.1

  New 4-/5-/6-/7-nitro-N'-(4-aryl-1,3-thiazol-2-yl)-1H-indole-2-carbohydrazides (4a-t) were prepared by treating respective nitroindole thiosemicarbazide with aromatic acylbromides. The newly synthesized compounds were characterized by analytical and spectral data. The compounds were also screened for antifungal and antibacterial activity. Some of the compounds exhibited promising antimicrobial activity.