Synthesis and effects on arginase and nitric oxide synthase of two novel analogues of Nω-hydroxyarginine, Nω-hydroxyindospicine and p-hydroxyamidinophenylalanine
摘要:
Two novel amino acids, N-omega-hydroxy-D,L-indospicine and p-hydroxyamidino-D,L-phenylalanine, have been synthesized in four steps from tert-butoxycarbonylglycine. Both compounds act as good inhibitors of arginase, N-omega-hydroxyindospicine being one of the best inhibitors of this enzyme known so far (IC50 = 50 mu mol dm(-3)). In contrast, with brain NO synthase the two compounds are almost without effect.
Synthesis and effects on arginase and nitric oxide synthase of two novel analogues of Nω-hydroxyarginine, Nω-hydroxyindospicine and p-hydroxyamidinophenylalanine
摘要:
Two novel amino acids, N-omega-hydroxy-D,L-indospicine and p-hydroxyamidino-D,L-phenylalanine, have been synthesized in four steps from tert-butoxycarbonylglycine. Both compounds act as good inhibitors of arginase, N-omega-hydroxyindospicine being one of the best inhibitors of this enzyme known so far (IC50 = 50 mu mol dm(-3)). In contrast, with brain NO synthase the two compounds are almost without effect.
Synthesis and effects on arginase and nitric oxide synthase of two novel analogues of N<sup>ω</sup>-hydroxyarginine, N<sup>ω</sup>-hydroxyindospicine and p-hydroxyamidinophenylalanine
Two novel amino acids, N-omega-hydroxy-D,L-indospicine and p-hydroxyamidino-D,L-phenylalanine, have been synthesized in four steps from tert-butoxycarbonylglycine. Both compounds act as good inhibitors of arginase, N-omega-hydroxyindospicine being one of the best inhibitors of this enzyme known so far (IC50 = 50 mu mol dm(-3)). In contrast, with brain NO synthase the two compounds are almost without effect.