t-butyl N-propargylaminoacetate | 66937-72-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: t-butyl N-propargylaminoacetate
• 英文别名: Tert-butyl 2-[(prop-2-yn-1-yl)amino]acetate；tert-butyl 2-(prop-2-ynylamino)acetate
• CAS: 66937-72-2
• 化学式: C₉H₁₅NO₂
• mdl: MFCD12148725
• 分子量: 169.224
• InChiKey: FHRJHJLYLHPRPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  t-butyl N-propargylaminoacetate 在 copper(II) sulfate 、 sodium ascorbate 作用下， 以 二氯甲烷 、 水 、 丙酮 为溶剂， 反应 48.0h， 生成 tert-butyl 2-[[1-[(2R,3R,4R,5S,6R)-3-acetamido-4,5-diacetyloxy-6-(acetyloxymethyl)oxan-2-yl]triazol-4-yl]methyl-(3-chloropropanoyl)amino]acetate
  参考文献：
  名称：

  Clickable Glycopeptoids for Synthesis of Glycopeptide Mimic

  摘要：

  Structurally diverse novel glycopeptoids were synthesized which can be attached to biologically important peptides by click reaction to improve their potential to be used in medicinal chemistry. Triazole-linked alpha beta-hydrid glycopeptoids were synthesized that mimic the conserved linkage region of N-linked glycoproteins in eukaryotes. The amide bonds were replaced with triazole rings, and alpha beta-hybrid peptoids were introduced as the backbone modification in peptidomimetics. In addition to their facile synthesis, these modifications have the possibility of introducing otherwise impossible conformations in the peptide backbone.

  DOI：

  10.1021/jo401720s
• 作为产物：
  描述：

  溴乙酸叔丁酯 、 炔丙胺 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 生成 t-butyl N-propargylaminoacetate
  参考文献：
  名称：

  高度方便的革兰氏溶液相类肽合成和正交侧链后修饰

  摘要：

  本文介绍了使用挥发性胺类化合物合成固相技术的一种非常方便的方法，该方法使用挥发性胺来合成β-，α，β-和α-四肽。柱色谱纯化减少到最少，大部分中间体通过过滤和/或蒸发纯化。该方法适用于类肽的克规模合成，并通过使用单击硫醇-烯偶联的连续和选择性连接对模型类肽进行后修饰，并证明了铜催化的叠氮化物-炔烃环加成反应。 类肽-低聚物-克级合成-硫醇-烯偶联-环加成-修饰后

  DOI：

  10.1055/s-0030-1258351

文献信息

• INSULIN CONJUGATES
  申请人：SANOFI

  公开号：US20200181223A1

  公开（公告）日：2020-06-11

  The present invention relates to a conjugate comprising a sulfonamide of formula (I) and an active pharmaceutical ingredient such as an insulin analog comprising at least one mutation relative to the parent insulin, wherein the insulin analog comprises a mutation at position B16 which is substituted with a hydrophobic amino acid and/or a mutation at position B25 which is substituted with a hydrophobic amino acid. The present invention further relates to a sulfonamide of formula (A). Moreover, the present invention relates to an insulin analog comprising at least one mutation relative to the parent insulin.

  本发明涉及一种共轭物，其包括公式（I）的磺胺类化合物和活性药用成分，例如含有至少一处相对于母体胰岛素的突变的胰岛素类似物，其中该胰岛素类似物在B16位置发生突变，被疏水氨基酸取代和/或在B25位置发生突变，被疏水氨基酸取代。本发明还涉及公式（A）的磺胺类化合物。此外，本发明涉及一种相对于母体胰岛素至少发生一处突变的胰岛素类似物。
• Polyimide precursor, polyimide, and liquid crystal aligning agent
  申请人：Nagao Masato

  公开号：US08901353B2

  公开（公告）日：2014-12-02

  To provide a novel diamine which is useful as the starting material of a novel polyimide precursor or polyimide which can provide a liquid crystal alignment film having a low volume resistivity, a liquid crystal aligning agent containing these polymers, and a liquid crystal alignment film. The novel diamine is a compound represented by any one of the following formulae (A) to (C):

  提供一种新型二胺，可用作新型聚酰亚胺前体或聚酰亚胺的起始材料，可提供具有低体积电阻率的液晶取向膜，其中包含这些聚合物的液晶取向剂，以及液晶取向膜。新型二胺是由以下任一式(A)到(C)表示的化合物：
• Highly Convenient Gram-Scale Solution-Phase Peptoid Synthesis and Orthogonal Side-Chain Post-Modification
  作者：Thomas Hjelmgaard、Sophie Faure、Cécile Caumes、Roland Remuson、Claude Taillefumier

  DOI：10.1055/s-0030-1258351

  日期：2011.1

  the development of a highly convenient solution-phase methodology using volatile amines for the synthesis of β-, α,β- and α-tetrapeptoids, as an alternative to solid-phase technologies. Column chromatographic purifications are reduced to a minimum and the majority of the intermediates are purified by filtration and/or evaporation. The method is amenable to gram-scale synthesis of peptoids, and post-modification

  本文介绍了使用挥发性胺类化合物合成固相技术的一种非常方便的方法，该方法使用挥发性胺来合成β-，α，β-和α-四肽。柱色谱纯化减少到最少，大部分中间体通过过滤和/或蒸发纯化。该方法适用于类肽的克规模合成，并通过使用单击硫醇-烯偶联的连续和选择性连接对模型类肽进行后修饰，并证明了铜催化的叠氮化物-炔烃环加成反应。 类肽-低聚物-克级合成-硫醇-烯偶联-环加成-修饰后
• POLYIMIDE PRECURSOR, POLYIMIDE, AND LIQUID CRYSTAL ALIGNING AGENT
  申请人：Nagao Masato

  公开号：US20120088888A1

  公开（公告）日：2012-04-12

  To provide a novel polyimide precursor or polyimide which can provide a liquid crystal alignment film having a low volume resistivity, a liquid crystal aligning agent containing these polymers, a liquid crystal alignment film and a novel diamine which is useful as the starting material of these polymers. A polyimide precursor having polymerized units represented by the formula (1), and characterized by satisfying any one of the following (i) to (iii): (i) the structure of X, Y or each of them in formula (1) has a group represented by the following formula (2); (ii) R 2 , R 3 or each of them in formula (1) is a group represented by the following formula (2); (iii) the structure of X, Y or each of them in formula (1) has a group represented by the following formula (2), and R 2 , R 3 or each of them is a group represented by following formula (2):

  提供一种新型聚酰亚胺前体或聚酰亚胺，可提供具有低体积电阻率的液晶取向膜，包含这些聚合物的液晶取向剂，液晶取向膜和一种新型二胺，作为这些聚合物的起始材料。聚酰亚胺前体具有由式（1）表示的聚合单元，其特征在于满足以下任一条件（i）至（iii）中的任一条件：（i）式（1）中的X、Y或它们中的每一个具有以下式（2）表示的基团的结构；（ii）式（1）中的R2、R3或它们中的每一个是以下式（2）表示的基团；（iii）式（1）中的X、Y或它们中的每一个具有以下式（2）表示的基团的结构，而R2、R3或它们中的每一个是以下式（2）表示的基团。
• Angiotensin-converting enzyme inhibitors. New orally active antihypertensive (mercaptoalkanoyl)- and [(acylthio)alkanoyl]glycine derivatives
  作者：John T. Suh、Jerry W. Skiles、Bruce E. Williams、Raymond D. Youssefyeh、Howard Jones、Bernard Loev、Edward S. Neiss、Alfred Schwab、William S. Mann

  DOI：10.1021/jm00379a013

  日期：1985.1

  A variety of N-substituted (mercaptoalkanoyl)- and [(acylthio)alkanoyl]glycine derivatives was synthesized and their ability in inhibiting the activity of angiotensin-converting enzyme (ACE) was examined in vitro and in vivo. The acylthio derivatives prepared are assumed to act as prodrugs since they are much less active than the corresponding free SH compounds in vitro and can be expected to act in vivo only after conversion to the free sulfhydryl compounds. A number of these compounds are potent ACE inhibitors that lowered blood pressure in Na-deficient, conscious spontaneously hypertensive rats (SHR), a high renin model. One of the most active members of the series was (S)-N-cyclopentyl-N-[3-[(2,2-dimethyl-1-oxopropyl)thio]-2-methyl-1 -oxopropyl]glycine (REV 3659-(S), pivopril). Structure-activity relationships are discussed.