Propyl-2-butinylether | 2791-30-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Propyl-2-butinylether
• 英文别名: but-2-ynyl-propyl ether；But-2-inyl-propyl-aether；1-Propyloxy-butin-(2)；1-Propoxybut-2-yne
• CAS: 2791-30-2
• 化学式: C₇H₁₂O
• 分子量: 112.172
• InChiKey: PRBFQHGQBCXYIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  Propyl-2-butinylether 在 乙醚 、 溴 作用下， 生成 2,3-dibromo-1-propoxy-but-2-ene
  参考文献：
  名称：

  Jozitsch; Orelkin, Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1910, vol. 42, p. 1081

  摘要：

  DOI：
• 作为产物：
  描述：

  乙烯基乙炔 、 potassium propylate 在 paraffin oil 作用下， 生成 Propyl-2-butinylether
  参考文献：
  名称：

  The Effect on Attribute Prediction of Location Uncertainty in Spatial Data

  摘要：

  A datum is considered spatial if it contains location information. Typically, there is also attribute information, whose distribution depends on its location. Thus, error in location information can lead to error in attribute information, which is reflected ultimately in the inference drawn from the data. We propose a statistical model for incorporating location error into spatial data analysis. We investigate the effect of location error on the spatial lag, the covariance function, and optimal spatial linear prediction (that is, kriging). We show that the form of kriging after adjusting for location error is the same as that of kriging without adjusting for location error. However, location error changes entries in the matrix of explanatory variables, the matrix of co‐variances between the sample sites, and the vector of covariances between the sample sites and the prediction location. We investigate, through simulation, the effect that varying trend, measurement error, location error, range of spatial dependence, sample size, and prediction location have on kriging after and without adjusting for location error. When the location error is large, kriging after adjusting for location error performs markedly better than kriging without adjusting for location error, in terms of both the prediction bias and the mean squared prediction error.

  DOI：

  10.1111/j.1538-4632.2002.tb01088.x

文献信息

• Persistence of the effects of Jet-A in a microcosm with releases from the sediment
  作者：Randy S. Sandberg、Wayne G. Landis

  DOI：10.1002/etc.5620200912

  日期：2001.9

  functional level effects of a release of a complex hydrocarbon mixture from sediments using a 60-d modified mixed flask culture (MFC) microcosm. Neat Jet-A was injected and mixed into the sediment with one nondosed and three dosed concentrations. Univariate and multivariate statistical and graphical techniques were used to detect patterns in the data. A slow release of the test material from the spiked sediment

  本研究使用 60 天改进的混合烧瓶培养 (MFC) 缩影研究从沉积物中释放复杂烃混合物的方法以及多物种和功能水平的影响。Neat Jet-A 以一种非剂量和三种剂量浓度注入并混合到沉积物中。单变量和多变量统计和图形技术用于检测数据中的模式。从加标的沉积层中获得了缓慢释放的测试材料，并检测了 Jet-A 的成分。功能参数（例如 pH 值）在确定治疗组方面通常比结构参数（种群密度）更好。对各种参数检测处理差异的能力的分析证实，对于生态结构的状况，没有一个最佳指标。在低至 2 微升/升的初始治疗浓度下观察到短暂但具有统计学意义的结果。在 63 天实验结束时，可以将较高浓度的治疗组与未给药或较低的治疗区分开来。三种多元技术中的每一种在实验过程中区分治疗组的能力都不同。
• Amino alcohol derivatives
  申请人：SANKYO COMPANY, LIMITED

  公开号：US20030236297A1

  公开（公告）日：2003-12-25

  Compounds of formula (I) which exhibit excellent immune suppression activity, pharmacologically acceptable salts thereof, esters thereof or other derivatives: 1 wherein R 1 and R 2 are a hydrogen atom, an amino protecting group; R 3 is a hydrogen atom, a hydroxy protecting group; R 4 is a lower alkyl group; n is an integer from 1 to 6; X is an ethylene group; Y is a C 1 -C 10 alkylene group, a C 1 -C 10 alkylene group substituted with 1 to 3 substituents selected from substituent group a and b; R 5 is an aryl group; R 6 and R 7 are a hydrogen atom, a group selected from substituent group a; with the proviso when R 5 is a hydrogen atom, Y is not a single bond or a straight chain C 1 -C 10 alkylene group.

  式（I）的化合物表现出优异的免疫抑制活性，其药理学上可接受的盐，酯或其他衍生物：其中R1和R2是氢原子，氨基保护基；R3是氢原子，羟基保护基；R4是较低的烷基基团；n是1到6之间的整数；X是乙烯基团；Y是C1-C10烷基基团，带有1到3个从取代基a和b中选择的取代基的C1-C10烷基基团；R5是芳基基团；R6和R7是氢原子，从取代基a中选择的基团；但是当R5是氢原子时，Y不是单键或直链的C1-C10烷基基团。
• [EN] BIFUNCTIONAL AGENTS FOR PROTEIN RECRUITMENT AND/OR DEGRADATION<br/>[FR] AGENTS BIFONCTIONNELS POUR LE RECRUTEMENT ET/OU LA DÉGRADATION DE PROTÉINES
  申请人：ORIONIS BIOSCIENCES INC

  公开号：WO2021126974A1

  公开（公告）日：2021-06-24

  The disclosure relates to new compounds, including bifunctional compounds, to be used as modulators of ubiquitination for targeted protein degradation.

  该披露涉及新化合物，包括双功能化合物，用作调节泛素化以实现靶向蛋白降解。
• 3-ALKOXY-1-PHENYLPYRAZOLE DERIVATIVES AND PESTICIDES
  申请人：Ohata Satoru

  公开号：US20100210704A1

  公开（公告）日：2010-08-19

  To provide pesticides such as insecticides, miticides and nematicides, which are excellent in the safety, pesticidal effects, residual effectiveness, etc., which further have infiltration, and which can be applied by soil treatment. A pesticide comprising a 3-alkoxy-1-phenyl-pyrazole derivative represented by the formula [I] or an agriculturally acceptable salt thereof as an active ingredient: wherein, for example, R 1 is a C 1 -C 10 alkyl group or the like, R 2 is a hydrogen atom or the like, R 3 is a hydrogen atom or the like, and each of R 4 , R 5 , R 6 and R 8 which are independent of one another, is a hydrogen atom or the like, and R 7 is a C 2 -C 4 haloalkylthio group or the like.

  提供杀虫剂，如杀虫剂，杀螨剂和杀线虫剂，这些杀虫剂在安全性、杀虫效果、残留效果等方面都非常出色，而且具有渗透性，可以通过土壤处理应用的杀虫剂。该杀虫剂包括以下公式[I]所表示的3-烷氧基-1-苯基-吡唑烷衍生物或其农业上可接受的盐作为活性成分：其中，例如，R1是C1-C10烷基或类似物，R2是氢原子或类似物，R3是氢原子或类似物，而且独立于彼此的R4、R5、R6和R8是氢原子或类似物，而R7是C2-C4卤代烷基硫基或类似物。
• AMINO ALCOHOL DERIVATIVE OR PHOSPHONIC ACID DERIVATIVE AND MEDICINAL COMPOSITION CONTAINING THESE
  申请人：Sankyo Company, Limited

  公开号：EP1471054A1

  公开（公告）日：2004-10-27

  The present invention relates to amino alcohol derivatives or phosphonic acid derivatives having excellent immunosuppressive activity, pharmacologically acceptable salts thereof or pharmacologically acceptable esters thereof, and to pharmaceutical compositions comprising said compounds as an active ingredient: [wherein,    R1 and R2 each represent a hydrogen atom, or a protecting group of the amino group;    R3 represents a hydrogen atom, or a protecting group of the hydroxyl group;    R4 represents a lower alkyl group;    n represents an integer of from 1 to 6;    X represents an oxygen atom or a nitrogen atom unsubstituted or substituted with a lower alkyl group or the like;    Y represents an ethylene group;    Z represents a C1-C10 alkylene group;    R5 represents an aryl group, or an aryl group substituted with substituents;    R6 and R7 each represents a hydrogen atom; provided that when R5 represents a hydrogen atom, then Z represents a group other than a single bond or a straight chain C1-C10 alkylene group] .

  本发明涉及具有优异免疫抑制活性的氨基醇衍生物或膦酸衍生物、其药理学上可接受的盐或其药理学上可接受的酯，以及包含上述化合物作为活性成分的药物组合物： 其中 R1 和 R2 分别代表氢原子或氨基的保护基团； R3 代表氢原子或羟基的保护基团； R4 代表低级烷基； n 代表 1 至 6 的整数； X 代表氧原子或氮原子，未被低级烷基或类似基团取代或取代； Y 代表乙烯基 Z 代表 C1-C10 烯基； R5 代表芳基或被取代基取代的芳基； R6 和 R7 各代表一个氢原子；但当 R5 代表氢原子时，Z 代表除单键或直链 C1-C10 亚烷基以外的基团]。