methyl 3-(4-methoxypyridin-2-yl) acrylate | 608881-04-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl 3-(4-methoxypyridin-2-yl) acrylate
• 英文别名: methyl 3-(4-methoxypyridin-2-yl)prop-2-enoate；Methyl 3-(4-methoxypyridin-2-yl)acrylate
• CAS: 608881-04-5
• 化学式: C₁₀H₁₁NO₃
• 分子量: 193.202
• InChiKey: SPNAMWMXLSLRHR-UHFFFAOYSA-N

物化性质

• 沸点：
  314.1±27.0 °C(Predicted)
• 密度：
  1.152±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  48.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 3-(4-methoxypyridin-2-yl) acrylate 在 钯 作用下， 以 甲醇 为溶剂， 生成 methyl 3-(4-methoxypyridin-2-yl) propionate
  参考文献：
  名称：

  IMIDAZOPYRIDINE-DERIVATIVES AS INDUCIBLE NO-SYNTHASE INHIBITORS

  摘要：

  式（I）化合物中，其中R1，R2，R3，R4，R5和A的含义如描述中所述，是新颖有效的iNOS抑制剂。

  公开号：

  US20100216790A1
• 作为产物：
  描述：

  4-甲氧基吡啶-2-醛 、 ethyl potassium malonate 在 哌啶 、 吡啶盐酸盐 作用下， 以 吡啶 为溶剂， 反应 2.0h， 以68%的产率得到methyl 3-(4-methoxypyridin-2-yl) acrylate
  参考文献：
  名称：

  Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights

  摘要：

  Inducible arginine oxidation and subsequent NO production by correspondent synthase (iNOS) are important cellular answers to proinflammatory signals. Prolonged NO production has been proved in higher organisms to cause stroke or septic shock. Several classes of potent NOS inhibitors have been reported, most of them targeting the arginine binding site of the oxygenase domain. Here we disclose the SAR and the rational design of potent and selective iNOS inhibitors which may be useful as anti-inflammatory drugs. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.05.073

文献信息

• [EN] IMIDAZO[4,5-B]QUINOLINE-DERIVATIVES AND THEIR USE AS NO-SYNTHASE INHIBITORS<br/>[FR] DERIVES DE IMIDAZO[4,5-B]QUINOLINE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE NO-SYNTHASE
  申请人：ALTANA PHARMA AG

  公开号：WO2004076451A1

  公开（公告）日：2004-09-10

  The compounds of formula I In which R1, R2, R3 and A have the meanings as given In the description are novel effective INOS Inhibitors.

  式I中的化合物，其中R1、R2、R3和A的含义如描述中所述，是新颖有效的iNOS抑制剂。
• [EN] PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF FGFR ACTIVITY<br/>[FR] DÉRIVÉS DE PYRIMIDINE ET LEUR UTILISATION EN TANT QUE MODULATEURS DE L'ACTIVITÉ DU FGFR
  申请人：ASTRAZENECA AB

  公开号：WO2009056886A1

  公开（公告）日：2009-05-07

  There is provided pyrimidine compounds of formula 1: or pharmaceutical salts thereof. There is al so provided processes for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy, for exampl e in the treatment of proliferative disease such as cancer and particular ly in disease mediated by a FGFR inhibitory effect.

  提供了化学式1的嘧啶化合物或其药用盐。还提供了其制备方法、含有它们的药物组合物、制备药物组合物的方法，以及它们在治疗中的应用，例如在治疗增殖性疾病如癌症以及由FGFR抑制作用介导的疾病中。
• [EN] IMIDAZOPYRIDINE-DERIVATIVES AS INDUCIBLE NO-SYNTHASE INHIBITORS<br/>[FR] DERIVES IMIDAZOPYRIDINE SERVANT D'INHIBITEURS DE NO-SYNTHASE INDUCTIBLE
  申请人：ALTANA PHARMA AG

  公开号：WO2005030770A1

  公开（公告）日：2005-04-07

  The compounds of formula (I) in which R1, R2, R3, R4, R5 and A have the meanings as given in the description are novel effective iNOS inhibitors.

  式（I）中R1、R2、R3、R4、R5和A的化合物具有描述中给出的含义，是新颖有效的iNOS抑制剂。
• [EN] IMIDAZOPYRIDINE-DERIVATIVES AS INDUCIBLE NO-SYNTHASE INHIBITORS<br/>[FR] DERIVES D'IMIDAZOPYRIDINE UTILISES COMME INHIBITEURS INDUCTIBLES DE LA NO SYNTHASE
  申请人：ALTANA PHARMA AG

  公开号：WO2005030769A1

  公开（公告）日：2005-04-07

  The compounds of formula (I) in which R1, R2, Het1 and A have the meanings as given in the description are novel effective iNOS inhibitors.

  公式（I）中R1，R2，Het1和A具有所述描述中给出的含义的化合物是新颖有效的iNOS抑制剂。
• [EN] IMIDAZOPYRIDINE-DERIVATIVES AS INDUCTIBLE NO-SYNTHASE INHIBITORS<br/>[FR] DERIVES IMIDAZOPYRIDINE SERVANT D'INHIBITEURS DE NO-SYNTHASE INDUCTIBLE
  申请人：ALTANA PHARMA AG

  公开号：WO2005030771A1

  公开（公告）日：2005-04-07

  The compounds of formula (I) in which R1, R2, R3, R4, R5 and A have the meanings as given in the description are novel effective iNOS inhibitors.

  式（I）中R1、R2、R3、R4、R5和A具有描述中给出的含义的化合物是新颖有效的iNOS抑制剂。