2-(5-(2,5-dimethyl-1H-pyrrol-1-yl)-2-propoxyphenyl)-5,6-diethylpyrimid-4(3H)-one | 1229017-83-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2-(5-(2,5-dimethyl-1H-pyrrol-1-yl)-2-propoxyphenyl)-5,6-diethylpyrimid-4(3H)-one
• 英文别名: 2-(5-(2,5-Dimethyl-1H-pyrrol-1-yl)-2-propoxyphenyl)-5,6-diethylpyrimid-4(3H)-one；2-[5-(2,5-dimethylpyrrol-1-yl)-2-propoxyphenyl]-4,5-diethyl-1H-pyrimidin-6-one
• CAS: 1229017-83-7
• 化学式: C₂₃H₂₉N₃O₂
• 分子量: 379.502
• InChiKey: XEPDEPFRLQUXDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-(5-nitro-2-n-propoxyphenyl)-5,6-diethyl-4(3H)-pyrimidone 在 palladium 10% on activated carbon 氢气 、 溶剂黄146 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 12.0h， 生成 2-(5-(2,5-dimethyl-1H-pyrrol-1-yl)-2-propoxyphenyl)-5,6-diethylpyrimid-4(3H)-one
  参考文献：
  名称：

  PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF

  摘要：

  公开号：

  EP2383262B1

文献信息

• Phenylpyrimidone Compounds, the Pharmaceutical Compositions, Preparation Methods and Uses Thereof
  申请人：Liu Zheng

  公开号：US20110301109A1

  公开（公告）日：2011-12-08

  The present invention relates to a class of phenylpyrimidone compounds, the pharmaceutical composition, the preparation method and the use thereof. More specifically, the present invention relates to a type of phenylpyrimidone compounds of the following formula I, the pharmaceutically acceptable salts or solvates thereof and to the pharmaceutical composition as well as the preparation method of the compounds. The compounds of formula I according to the present invention can effectively inhibit type V phosphodiesterase (PDE5), and thus can be used for the treatment of various vascular disorders, such as male erectile dysfunction, pulmonary hypertension and the like.

  本发明涉及一类苯基嘧啶酮化合物、制药组合物、其制备方法和用途。更具体地说，本发明涉及以下式I的一类苯基嘧啶酮化合物、其制药学上可接受的盐或溶剂以及化合物的制药组合物和制备方法。根据本发明的式I化合物可以有效抑制第V型磷酸二酯酶（PDE5），因此可以用于治疗各种血管障碍，例如男性勃起功能障碍、肺动脉高压等。
• Phenylpyrimidone compounds, the pharmaceutical compositions, preparation methods and uses thereof
  申请人：Liu Zheng

  公开号：US08871777B2

  公开（公告）日：2014-10-28

  The present invention relates to a class of phenylpyrimidone compounds, the pharmaceutical composition, the preparation method and the use thereof. More specifically, the present invention relates to a type of phenylpyrimidone compounds of the following formula I, the pharmaceutically acceptable salts or solvates thereof and to the pharmaceutical composition as well as the preparation method of the compounds. The compounds of formula I according to the present invention can effectively inhibit type V phosphodiesterase (PDE5), and thus can be used for the treatment of various vascular disorders, such as male erectile dysfunction, pulmonary hypertension and the like.

  本发明涉及一类苯基嘧啶酮化合物、制药组合物、制备方法及其用途。更具体地说，本发明涉及以下式I的一类苯基嘧啶酮化合物、其药学上可接受的盐或溶剂和药物组合物以及化合物的制备方法。本发明的式I化合物能够有效地抑制V型磷酸二酯酶（PDE5），因此可以用于治疗各种血管障碍，例如男性勃起功能障碍、肺动脉高压等。
• US8871777B2
  申请人：——

  公开号：US8871777B2

  公开（公告）日：2014-10-28
• PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF
  申请人：Topharman Shanghai Co., Ltd.

  公开号：EP2383262B1

  公开（公告）日：2016-07-06