metronidazole | 5006-72-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: metronidazole
• 英文别名: 2-methyl-5-nitro-1-propyl-1H-imidazole；2-methyl-5-nitro-1-imidazole ethanol；2-methyl-5-nitro-1-propyl-1H-imidazole；2-methyl-5-nitro-1-propylimidazole
• CAS: 5006-72-4
• 化学式: C₇H₁₁N₃O₂
• mdl: MFCD02292832
• 分子量: 169.183
• InChiKey: GMTVTGSZZFRDSK-UHFFFAOYSA-N

物化性质

• 熔点：
  60-61 °C
• 沸点：
  326.0±15.0 °C(Predicted)
• 密度：
  1.24±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.571
• 拓扑面积：
  63.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-甲基-4-硝基咪唑 、 溴丙烷 生成 metronidazole
  参考文献：
  名称：

  Bhujanga Rao A. K. S., Gundu Rao C., Singh B. B., J. Chem. Soc. Perkin Trans. 1, (1994) N 17, S 2399-2402

  摘要：

  DOI：

文献信息

• 2,4,6-TRIAMINO-1,3,5-TRIAZINE DERIVATIVE
  申请人：Kubota Hideki

  公开号：US20080227785A1

  公开（公告）日：2008-09-18

  This invention relates to an anti-dementia agent which uses a BEC 1 potassium channel inhibitor as the active ingredient. It was proved that the BEC 1 potassium channel inhibitor has an action to improve learning disorder and is useful as a preventive or therapeutic agent for diseases, preferably dementia, in which the BEC 1 potassium channel is considered to be concerned. Illustratively, it was confirmed by an in vivo test that the BEC 1 potassium channel inhibitor has an action to improve learning disorder. Also, it was found that a compound having 2,4,6-triamino-1,3,5-triazine has a BEC 1 potassium channel inhibitory action.

  本发明涉及一种以BEC 1钾离子通道抑制剂作为活性成分的抗痴呆剂。已经证明，BEC 1钾离子通道抑制剂具有改善学习障碍的作用，并且作为预防或治疗剂是有用的，尤其是对于BEC 1钾离子通道与之相关的疾病，如痴呆症。例如，通过体内试验证实，BEC 1钾离子通道抑制剂具有改善学习障碍的作用。此外，还发现具有2,4,6-三氨基-1,3,5-三嗪的化合物具有BEC 1钾离子通道抑制作用。
• Novel tetrahydropyridothiophenes
  申请人：Pekari Klaus

  公开号：US20070244112A1

  公开（公告）日：2007-10-18

  Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel, effective compounds with anti-proliferative and/or apoptosis inducing activity.

  具有某个化学式（I）的化合物，其中Ra和Rb的含义如描述中所示，是一种新颖、有效的具有抗增殖和/或诱导细胞凋亡活性的化合物。
• Novel Compounds and Use of Tetrahydropyridothiophenes
  申请人：Pekari Klaus

  公开号：US20070259911A1

  公开（公告）日：2007-11-08

  The compounds of a certain formula (1) in which Ra and Rb have the meanings indicated in the description are novel for treating hyperproliferative diseases and/or disorders responsive to the induction of apoptosis. The invention further relates to certain compounds of formula (I), in which Ra and Rb have the meanings indicated in the description.

  某个公式（1）的化合物，其中Ra和Rb具有说明中指示的含义，是用于治疗过度增殖性疾病和/或对诱导凋亡有反应的疾病的新颖物质。本发明还涉及某些公式（I）中的化合物，其中Ra和Rb具有说明中指示的含义。
• NOVEL TETRAHYDROPYRIDOTHIOPHENES
  申请人：PEKARI Klaus

  公开号：US20090270378A1

  公开（公告）日：2009-10-29

  Compounds of a certain formula (I), in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and/or apoptosis inducing activity.

  某种式(I)的化合物，其中Ra和Rb具有说明中所示的含义，是具有抗增殖和/或诱导凋亡活性的新型有效化合物。
• EXPANDED THERAPEUTIC POTENTIAL IN NITROHETEROARYL ANTIMICROBIALS
  申请人：The Regents of the University of California

  公开号：US20160244435A1

  公开（公告）日：2016-08-25

  Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to imidazole, thiazole, and furan derivatives and their use as therapeutic agents.

  本文披露了抗微生物化合物组成物、制药组合物、其使用和制备方法。其中一些实施例涉及咪唑、噻唑和呋喃衍生物及其作为治疗剂的使用。