methyl 4-[(7-chloro-4-hydroxy-1,10-dioxo-2,5-dihydropyridazino[4,5-b]quinolin-2-yl)methyl]benzoate | 349104-92-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: methyl 4-[(7-chloro-4-hydroxy-1,10-dioxo-2,5-dihydropyridazino[4,5-b]quinolin-2-yl)methyl]benzoate
• 英文别名: Methyl 4-[(7-chloro-1,4,10-trioxo-3,5-dihydropyridazino[4,5-b]quinolin-2-yl)methyl]benzoate
• CAS: 349104-92-3
• 化学式: C₂₀H₁₄ClN₃O₅
• 分子量: 411.801
• InChiKey: QDJOQDJWGUVCQX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Methods and compositions for the treatment of pain
  申请人：——

  公开号：US20030181449A1

  公开（公告）日：2003-09-25

  A method for the treatment of pain is disclosed comprising administration of a pain-ameliorating effective amount of any compound according to structural diagram I; 1 wherein A, D and R 1 are as defined in the specification. Also disclosed are pharmaceutical compositions comprising a pain-ameliorating effective amount of a compound in accord with structural diagram I.

  本发明揭示了一种治疗疼痛的方法，包括给予结构图I中的任何化合物的疼痛减轻有效量，其中A、D和R1如规范所定义。此外，本发明还揭示了包括符合结构图I的化合物的疼痛减轻有效量的药物组合物。
• METHODS AND COMPOSITIONS FOR THE TREATMENT OF PAIN
  申请人：AstraZeneca AB

  公开号：EP1244660A1

  公开（公告）日：2002-10-02
• [EN] METHODS AND COMPOSITIONS FOR THE TREATMENT OF PAIN<br/>[FR] PROCEDES ET COMPOSITIONS POUR LE TRAITEMENT DE LA DOULEUR
  申请人：ASTRAZENECA AB

  公开号：WO2001047924A1

  公开（公告）日：2001-07-05

  A method for the treatment of pain is disclosed comprising administration of a pain-ameliorating effective amount of any compound according to structural diagram (I); wherein A, D and R1 are as defined in the specification. Also disclosed are pharmaceutical compositions comprising a pain-ameliorating effective amount of a compound in accord with structural diagram (I).