1-isobutoxy-butan-2-ol | 127561-83-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-isobutoxy-butan-2-ol
• 英文别名: 1-(2-Methylpropoxy)butan-2-ol
• CAS: 127561-83-5
• 化学式: C₈H₁₈O₂
• 分子量: 146.23
• InChiKey: KWTOTYSWIVSMPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-isobutoxy-butan-2-ol 、 1,4-二氯丁烷 、 四丁基铵亚硫酸酯 以51%的产率得到
  参考文献：
  名称：

  RENTZEA, COSTIN;AMMERMANN, EBERHARD;LORENZ, GISELA

  摘要：

  DOI：
• 作为产物：
  描述：

  1-isobutoxy-butan-2-one 在 乙醇 、 sodium 作用下， 生成 1-isobutoxy-butan-2-ol
  参考文献：
  名称：

  Blaise; Picard, Annales de Chimie (Cachan, France), 1912, vol. <8>26, p. 270

  摘要：

  DOI：

文献信息

• The synthesis of butene glycol ethers with aluminium triflate
  作者：Yvette M Terblans、Michelle Huyser、Desmond A Young、Michael J Green

  DOI：10.1139/v06-086

  日期：2006.6.1

  The use of aluminium triflate as a ring-opening catalyst for butene oxide (BuO) was evaluated in the presence of different alcohols such as methanol, ethanol, n-propanol, n-butanol, 2-propanol, 2-methyl-1-propanol, and 2-methyl-2-propanol. The reaction with methanol was studied kinetically by varying the temperature, catalyst concentration, and methanol – butene oxide molar ratio. These reactions yielded two major products (2-methoxy-1-butanol and 1-methoxy-2-butanol) in a approximate ratio of 1:1. It was noted that at low catalyst concentrations (<5 ppm), low temperatures (<90 °C), and a MeOH–BuO molar ratio of 8:1, the selectivity of the reaction could be kinetically manipulated to shift the product ratio towards 1-methoxy-2-butanol, the α-alkoxyalcohol. This result was confirmed by an experimental design program. Statistical calculations using the data from the experimental design identified a feasible region in which reactions with methanol could be carried out, which would lead to slightly higher selectivities to 1-methoxy-2-butanol. This region shows that the methanol – butene oxide ratio should be 8:1, the temperature between 80 and 85 °C, and the catalyst concentration between 3.9 and 5 ppm. These reaction conditions were used to carry out a test reaction with methanol and an extended series of alcohols. All the alcohols, except for 2-methyl-2-propanol, reacted with butene oxide under these conditions, with the selectivity to the α-alkoxyalcohol higher than to the β-alkoxyalcohol. To obtain a ring-opening reaction with 2-methyl-2-propanol, it was found that a higher catalyst concentration (approximately 10 ppm) and a lower alcohol – butene oxide ratio (6:1) at a temperature of 80 °C were necessary. This reaction led to a mixture of 1-tert-butoxy-2-butanol and 2-tert-butoxy-1-butanol with the selectivity to the α-alkoxyalcohol being somewhat higher because of the steric influence of the bulky tert-butoxy group.Key words: aluminium triflate, alcohols, butene oxide, ring opening, α-alkoxyalcohol, β-alkoxyalcohol.

  在甲醇、乙醇、正丙醇、正丁醇、2-丙醇、2-甲基-1-丙醇和 2-甲基-2-丙醇等不同醇类存在的情况下，对使用三酸铝作为氧化丁烯（BuO）的开环催化剂进行了评估。通过改变温度、催化剂浓度和甲醇氧化丁烯摩尔比，对与甲醇的反应进行了动力学研究。这些反应产生了两种主要产物（2-甲氧基-1-丁醇和 1-甲氧基-2-丁醇），比例约为 1:1。我们注意到，在催化剂浓度较低（5 ppm）、温度较低（90 °C）、MeOH-BuO 摩尔比为 8:1 的条件下，反应的选择性可以通过动力学调节，使产物比例向 1-甲氧基-2-丁醇（即 α-烷氧基乙醇）转移。实验设计程序证实了这一结果。利用实验设计数据进行的统计计算确定了一个可行的区域，在该区域内可以与甲醇进行反应，从而使 1-甲氧基-2-丁醇的选择性略高。该区域表明，甲醇与氧化丁烯的比例应为 8:1，温度应在 80 至 85 ℃ 之间，催化剂浓度应在 3.9 至 5 ppm 之间。利用这些反应条件与甲醇和一系列醇类进行了试验反应。在这些条件下，除 2-甲基-2-丙醇外，所有醇都与环氧丁烯发生了反应，对 α-烷氧基乙醇的选择性高于对 β-烷氧基乙醇的选择性。要与 2-甲基-2-丙醇发生开环反应，需要在 80 °C 的温度下使用较高的催化剂浓度（约 10 ppm）和较低的氧化醇丁烯比（6:1）。该反应生成了 1-叔丁氧基-2-丁醇和 2-叔丁氧基-1-丁醇的混合物，由于笨重的叔丁氧基基团的立体影响，α-烷氧基乙醇的选择性更高。
• Cyclische Amine und diese enthaltende Fungizide
  申请人：BASF Aktiengesellschaft

  公开号：EP0345657A2

  公开（公告）日：1989-12-13

  Amine der allgemeinen Formel I worin n die ganzen Zahlen 2 bis 10, X Sauerstoff oder Schwefel, Z Sauerstoff oder CH-Rs bedeutet und R1, R2, R3, R4 und R5 Wasserstoff oder Alkyl bedeuten, sowie deren Salze und diese Verbindungen enthaltende Fungizide.

  通式 I 的胺 其中 n 为 2 至 10 的整数、 X 是氧或硫 Z 是氧或 CH-Rs，以及 R1、R2、R3、R4 和 R5 表示氢或烷基，以及它们的盐和含有这些化合物的杀菌剂。
• Void-containing layer, laminate, method for producing void-containing layer, optical member, and optical apparatus
  申请人：NITTO DENKO CORPORATION

  公开号：US11384259B2

  公开（公告）日：2022-07-12

  A void-containing layer is disclosed in which a pressure-sensitive adhesive or an adhesive is less likely penetrated into voids. The void-containing layer of the present invention includes: nanoparticles, surfaces of which are modified with a compound having a surface orientation, wherein the void-containing layer has a void fraction of 35 vol %.

  本发明公开了一种含空隙层，其中的压敏胶或粘合剂不易渗入空隙。本发明的含空隙层包括：纳米颗粒，其表面用具有表面取向性的化合物修饰，其中含空隙层的空隙率为 35 Vol %。
• RENTZEA, COSTIN;AMMERMANN, EBERHARD;LORENZ, GISELA
  作者：RENTZEA, COSTIN、AMMERMANN, EBERHARD、LORENZ, GISELA

  DOI：——

  日期：——
• FATTY ACID CYSTEAMINE CONJUGATES AND THEIR USE AS ACTIVATORS OF AUTOPHAGY
  申请人：Catabasis Pharmaceuticals, Inc.

  公开号：US20170258741A1

  公开（公告）日：2017-09-14

  The invention relates to (i) 6-membered heteroaryl substituted fatty acid cystamine conjugates, compositions thereof, methods of treating diseases involving dysregulation of autophagy, such as cystic fibrosis, idiopathic pulmonary fibrosis (IPF), a neurodegenerative disease, inflammatory disease, liver disease, muscle disease, infection and immune disease with this compound, or (ii) a method of treating idiopathic pulmonary fibrosis, mitochondrial diseases, Leigh Syndrome, Diabetes Mellitus and Deafness (DAD), Leber's hereditary optic neuropathy, Neuropathy-ataxia-retinis pigmentosa and ptosis (NARP), myoneurogenic gastrointestinal encephalopathy (MNG1E), myoclonic epilepsy with ragged red fibers (MERRF), or mitochondrial myopathy-encephalomy-opathy-lactic acidosis stroke like symptoms (MELAS), comprising administering to a patient the fatty acid cysteamine conjugate, (4Z, 7Z. 10Z, 13Z, 16Z, 19Z)—N-(2-mercaptoethyl) docosa-4,7,10,13,16,19-hexaenamide or (5Z, 8Z, 11Z, 14Z, 17Z)—N-(2-mercaptoethyl) icosa-5,8,11,14,17-pentaenamide.