3,3-diethoxyhexane | 408511-19-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,3-diethoxyhexane
• 英文别名: hexan-3-one-diethylacetal；Aethylpropylketon-diaethylacetal；Hexan-3-on-diaethylacetal；3.3-Diethoxy-hexan
• CAS: 408511-19-3
• 化学式: C₁₀H₂₂O₂
• 分子量: 174.283
• InChiKey: GVEXCKAZJYTOEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-己酮 、 原甲酸三乙酯 在 硫酸 作用下， 生成 3,3-diethoxyhexane
  参考文献：
  名称：

  Arbusow, Zeitschrift fur Physikalische Chemie, Stoechiometrie und Verwandtschaftslehre, 1926, vol. 121, p. 211

  摘要：

  DOI：

文献信息

• Platinum(II)-catalyzed addition of alcohols to alkynes
  作者：John W. Hartman、Luke Sperry

  DOI：10.1016/j.tetlet.2004.03.069

  日期：2004.5

  A simple, high-yielding synthesis of acetals from the platinum(II)-catalyzed addition of alcohols to alkynes is described. The regioselectivity of the method and its mechanism are also discussed.

  描述了由铂（II）催化的醇向炔烃的简单，高产率的乙缩醛合成。还讨论了该方法的区域选择性及其机理。
• Ewlampiew, Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1924, vol. 54, p. 462
  作者：Ewlampiew

  DOI：——

  日期：——
• Extensive Experimental and Computational Study of Counterion Effect in the Reaction Mechanism of NHC-Gold(I)-Catalyzed Alkoxylation of Alkynes
  作者：Marina Trinchillo、Paola Belanzoni、Leonardo Belpassi、Luca Biasiolo、Vincenzo Busico、Angela D’Amora、Lorenzo D’Amore、Alessandro Del Zotto、Francesco Tarantelli、Angela Tuzi、Daniele Zuccaccia

  DOI：10.1021/acs.organomet.5b00925

  日期：2016.3.14

  Herein, we synthesized and characterized through NMR and X-ray techniques a new set of [(NHC)-Au-X] complexes (NHC = 1,3-bis(2,6-diisopropylphenyl)-imidazol-2-ylidene), differing in the counterion X (X = OMs , NO3 , ClO4 , 2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptanoate (PFHp )). All of these complexes, together with those already known having NTf2 and phthalimide (ptm ) as counterions, were tested as catalysts in the methoxylation of 3-hexyne. The results were analyzed together with those obtained previously. The values of activation parameters (Delta H-? and Delta S-?) for different anions are also reported. The overall catalytic and kinetic evidence, together with an extensive computational work, confirm the general mechanistic picture given recently in which the anion plays an active role in all steps of the reaction mechanism: pre-equilibrium, nucleophilic attack, and protodeauration. Medium-coordinating anions (OMs , OTs ) containing a highly symmetric anchoring group give the best catalytic performances. This is due to the following reasons: (a) the pre-equilibrium is shifted toward the outer sphere ion pair, (b) their characteristic basicity promotes the nucleophilic attack, and (c) the possible paths leading to the deactivation of the catalyst are inhibited. These highly symmetric tridentate anions destabilize the unreactive tricoordinated gold species, which instead may be formed by anions with a planar anchoring group, such as PFHp and TFA . A general trend between coordinating ability and catalytic performances in the alkoxylation of alkynes may be established only when the geometric features of the anion are taken into account. The role of the anion has been also investigated in connection with the nature of the nucleophile. In particular, when the alcohol is a poor nucleophile, a large difference in reactivity is observed, while the use of suitably functionalized alcohols, which may contribute to polarizing the -OH bond through intramolecular interactions, flattens the anion effect.
• Erythromycin a derivatives and method for the preparation of the same
  申请人：TAISHO PHARMACEUTICAL CO. LTD

  公开号：EP0272110B1

  公开（公告）日：1993-04-07
• SOLID CATALYST FOR OLEFIN POLYMERIZATION AND PROCESS FOR PRODUCING OLEFIN POLYMER
  申请人：Sumitomo Chemical Company, Limited

  公开号：US20130072648A1

  公开（公告）日：2013-03-21

  A solid catalyst for olefin polymerization and a process for producing an olefin polymer are provided. The polymer has a small content of a component which is dissolved out into a low temperature organic solvent, such as a low-molecular weight component and an amorphous component. The solid catalyst is obtained by bringing a solid catalyst component for olefin polymerization containing a titanium atom, a magnesium atom, a halogen atom, and an aliphatic carboxylate; an organoaluminum compound; and a compound represented by formula (I) into contact with each other: wherein R 1 is a hydrocarbyl group having 1 to 10 carbon atoms, R 2 is a hydrogen atom, a halogen atom or a hydrocarbyl group having 1 to 16 carbon atoms, and the R 1 the R 2 groups are independently the same or different, and the respective R 1 groups and R 2 groups may be joined with each other to form a ring.