Methyl 2-(n-butylthio)acetate | 10309-14-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Methyl 2-(n-butylthio)acetate
• 英文别名: methyl 2-(butylthio)acetate；butylsulfanyl-acetic acid methyl ester；Butylmercapto-essigsaeure-methylester；S-Butyl-thioglykolsaeure-methylester；Butylmercaptoessigsaeure-methylester；S-n-Butylthioglykolsaeuremethylester；Acetic acid, (butylthio)-, methyl ester；methyl 2-butylsulfanylacetate
• CAS: 10309-14-5
• 化学式: C₇H₁₄O₂S
• mdl: MFCD12144348
• 分子量: 162.253
• InChiKey: CBNVDXXHRGFAJU-UHFFFAOYSA-N

物化性质

• 沸点：
  204.1±23.0 °C(Predicted)
• 密度：
  1.004±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  51.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Methyl 2-(n-butylthio)acetate 在 水 、 双氧水 作用下， 以 溶剂黄146 、 甲苯 为溶剂， 反应 96.0h， 生成 methyl 2-[(S)-butylsulfinyl]acetate
  参考文献：
  名称：

  制备手性亚砜的简便方法

  摘要：

  以非常高的光学收率得到亚甲基乙酸乙酸甲酯和亚砜（R）-（1）-（6）的生物催化拆分；该产品已用于系统研究“ SPAC”反应，即不对称合成γ-羟基-α，β-不饱和酯。

  DOI：

  10.1016/s0040-4039(01)80467-6
• 作为产物：
  描述：

  (丁基硫代)乙酸 在 三氯化磷 作用下， 生成 Methyl 2-(n-butylthio)acetate
  参考文献：
  名称：

  Is Information Risk a Determinant of Asset Returns?

  摘要：

  ABSTRACTWe investigate the role of information‐based trading in affecting asset returns. We show in a rational expectation example how private information affects equilibrium asset returns. Using a market microstructure model, we derive a measure of the probability of information‐based trading, and we estimate this measure using data for individual NYSE‐listed stocks for 1983 to 1998. We then incorporate our estimates into a Fama and French (1992) asset‐pricing framework. Our main result is that information does affect asset prices. A difference of 10 percentage points in the probability of information‐based trading between two stocks leads to a difference in their expected returns of 2.5 percent per year.

  DOI：

  10.1111/1540-6261.00493

文献信息

• Reaction of methyl diazoacetate with aldehydes, amines, thiols, alcohols and acids over transition metal-exchanged clays
  作者：Prodeep Phukan、Jakkam Madan Mohan、Arumugam Sudalai

  DOI：10.1039/a905028k

  日期：——

  Metal-exchanged clays (M = Rh and Cu) catalyze effectively the reaction of methyl diazoacetate with various aldehydes, affording the corresponding β-keto esters in high yields. They have also been effective in the decomposition of methyl diazoacetate to form metallocarbenes which, in turn, successfully insert into X–H (X = N, O, S, CO2) bonds of a variety of amines, aldehydes, thiols and acids, thereby producing the corresponding esters.

  金属交换粘土（M = Rh 和 Cu）能有效催化重氮乙酸甲酯与各种醛的反应，从而以较高的产率获得相应的 β-酮酯。它们还能有效地分解重氮乙酸甲酯，形成金属羰基，而金属羰基又能成功地插入各种胺、醛、硫醇和酸的 X-H（X=N、O、S、CO2）键，从而生成相应的酯。
• Enzymatic Resolution of α-acetoxysulfides: A new approach to the synthesis of homochiral S,O-Acetals
  作者：John Milton、Stephen Brand、Martin F. Jones、Christopher M. Rayner

  DOI：10.1016/0957-4166(95)00248-n

  日期：1995.8

  A novel enzymatic resolution of alpha-acetoxysulfides using Pseudomonas fluorescens lipase is reported. Selectivity is highly dependent on the substrate and solvent, with enantiomeric excesses of >95% in some cases. We believe these are the first examples of enzymatic resolutions of an S,O-acetal.
• Kennedy, Michael; McKervey, M. Anthony; Maguire, Anita R., Journal of the Chemical Society. Perkin transactions I, 1990, # 4, p. 1041 - 1045
  作者：Kennedy, Michael、McKervey, M. Anthony、Maguire, Anita R.、Naughton, Sean

  DOI：——

  日期：——
• Synthesis of 4-Substituted Methyl 3-(2,3-Epoxy)propoxythiophene-2-carboxylates
  作者：Jaime Lissavetzky、Ignacio Manzanares

  DOI：10.3987/com-95-7324

  日期：——

  The synthesis of 4-substituted methyl 3-hydroxythiophene-2-carboxylates is reported. The selective O-alkylation by two methods of these compounds gives the correspondent epoxy derivatives.
• BURGESS, KEVIN;HENDERSON, IAN, TETRAHEDRON LETT., 30,(1989) N8, C. 3633-3636
  作者：BURGESS, KEVIN、HENDERSON, IAN

  DOI：——

  日期：——