α-hydroxy-delta-butyrolactone | 52287-99-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环氧化物
• 英文名称: α-hydroxy-delta-butyrolactone
• 英文别名: α-hydroxybutyrolactone；2-hydroxybutyrolactone；alpha-Butyrolactone；3-ethyloxiran-2-one
• CAS: 52287-99-7
• 化学式: C₄H₆O₂
• 分子量: 86.0904
• InChiKey: ZOMPBXWFMAJRRU-UHFFFAOYSA-N

物化性质

• 沸点：
  68-70 °C(Press: 15 Torr)
• 密度：
  1.098±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  6
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  29.6
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2932209090

反应信息

• 作为反应物：
  描述：

  α-hydroxy-delta-butyrolactone 在 selenium 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 45.67h， 以75%的产率得到DL-α-hydroxyselenomethionine
  参考文献：
  名称：

  [EN] SELENOHYDROXY ACIDS AND THEIR DERIVATIVES, APPLICATIONS IN NUTRITION, COSMETICS AND PHARMACEUTICS
  [FR] NOUVEAUX ACIDES D'HYDROXYDE DE SELENIUM, DERIVES DE CES ACIDES ET LEURS APPLICATIONS DANS LES DOMAINES ALIMENTAIRE, COSMETIQUE ET PHARMACEUTIQUE

  摘要：

  公开号：

  WO2006008190A3
• 作为产物：
  描述：

  DL-2-氨基丁酸 在 sodium dihydrogenphosphate 、 sodium perchlorate 、 sodium nitrite 作用下， 生成 α-hydroxy-delta-butyrolactone
  参考文献：
  名称：

  Amino Acid Nitrosation Products as Alkylating Agents

  摘要：

  Nitrosation reactions of alpha-, beta-, and gamma -amino acids whose reaction products can act as alkylating agents of DNA were investigated. To approach in vivo conditions for the two-step mechanism (nitrosation and alkylation), nitrosation reactions were carried out in aqueous acid conditions (mimicking the conditions of the stomach lumen) while the alkylating potential of the nitrosation products was investigated at neutral pH, as in the stomach lining cells into which such products can diffuse. These conclusions were drawn: (i) The alkylating species resulting from the nitrosation of amino acids with an -NH2 group are the corresponding lactones, (ii) the sequence of alkylating power is: alpha -lactones > beta -lactones > gamma -lactones, coming respectively from the nitrosation of alpha-, beta-, and gamma -amino acids; and (iii) the results obtained may be useful in predicting the mutagenic effectiveness of the nitrosation products of amino acids.

  DOI：

  10.1021/ja010348+

文献信息

• Process for preparing pyrrolidinones
  申请人：Zeneca Limited

  公开号：US05670656A1

  公开（公告）日：1997-09-23

  A process for the preparation of a compound of general formula II: ##STR1## wherein R.sup.1 is hydrogen, or C.sub.1 -C.sub.10 hydrocarbyl or heterocyclyl having 3 to 8 ring atoms, either of which may optionally be substituted; each R.sup.2, R.sup.3, R.sup.4 and R.sup.5 is independently hydrogen or C.sub.1 -C.sub.4 alkyl; A is an optionally substituted aromatic or heteroaromatic ring system; and R.sup.21 is hydrogen, halogen, OH or OCONHR.sup.1, wherein R.sup.1 is as defined above; the process comprising cyclizing a compound of general formula III: ##STR2## wherein A, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.21 are as defined in general formula II and R.sup.25 is a leaving group such as a halogen atom; under basic conditions.

  一种制备一般式II化合物的方法：其中R.sup.1是氢，或者是具有3至8个环原子的C.sub.1 -C.sub.10烃基或杂环烷基，其中任一者可选择性地被取代；每个R.sup.2、R.sup.3、R.sup.4和R.sup.5独立地是氢或C.sub.1 -C.sub.4烷基；A是可选择性地取代的芳香或杂芳环系统；R.sup.21是氢、卤素、OH或OCONHR.sup.1，其中R.sup.1如上所定义；该方法包括使一般式III化合物环化：其中A、R.sup.2、R.sup.3、R.sup.4、R.sup.5和R.sup.21如一般式II中所定义，而R.sup.25是一种离去基团，如卤素原子；在碱性条件下。
• NOVEL TRIALKYL CATIONIC LIPIDS AND METHODS OF USE THEREOF
  申请人：Heyes James

  公开号：US20120172411A1

  公开（公告）日：2012-07-05

  The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

  本发明提供了用于将治疗剂传递至细胞的组合物和方法。具体包括新型阳离子脂质和核酸-脂质颗粒，可有效地封装核酸并有效地将封装的核酸传递至体内的细胞。本发明的组合物非常强效，因此可以在相对较低的剂量下有效地降低特定靶蛋白的表达。此外，本发明的组合物和方法与先前已知的组合物和方法相比，毒性更低，并提供更大的治疗指数。
• Insecticidal esters derived from benzocycloalkane-thiophenemethyl
  申请人：FMC Corporation

  公开号：US04487778A1

  公开（公告）日：1984-12-11

  Certain benzocycloalkaneheteroaromaticmethyl, e.g., benzocycloalkanethiophenemethyl, esters and insecticidal compositions containing these esters are useful for the control of a broad range of insects and acarids.

  某些苯并环烷杂芳基甲基，例如苯并环烷硫代苯甲基酯，以及含有这些酯的杀虫剂组合物，对于控制广泛范围的昆虫和螨类有用。
• Benzocycloalkane-thiophenemethyl compounds as intermediates
  申请人：FMC Corporation

  公开号：US04605748A1

  公开（公告）日：1986-08-12

  Certain benzocycloalkaneheteroaromaticmethyl, e.g., benzocycloalkanethiophenemethyl, esters and insecticidal compositions containing these esters are useful for the control of a broad range of insects and acarids.

  某些苯并环烷杂芳基甲基，例如苯并环烷硫吩甲基酯，以及含有这些酯的杀虫剂组合物，可用于控制广泛范围的昆虫和螨类。
• Amino Acid Nitrosation Products as Alkylating Agents
  作者：M. del Pilar García-Santos、Emilio Calle、Julio Casado

  DOI：10.1021/ja010348+

  日期：2001.8.1

  Nitrosation reactions of alpha-, beta-, and gamma -amino acids whose reaction products can act as alkylating agents of DNA were investigated. To approach in vivo conditions for the two-step mechanism (nitrosation and alkylation), nitrosation reactions were carried out in aqueous acid conditions (mimicking the conditions of the stomach lumen) while the alkylating potential of the nitrosation products was investigated at neutral pH, as in the stomach lining cells into which such products can diffuse. These conclusions were drawn: (i) The alkylating species resulting from the nitrosation of amino acids with an -NH2 group are the corresponding lactones, (ii) the sequence of alkylating power is: alpha -lactones > beta -lactones > gamma -lactones, coming respectively from the nitrosation of alpha-, beta-, and gamma -amino acids; and (iii) the results obtained may be useful in predicting the mutagenic effectiveness of the nitrosation products of amino acids.