2-chlorophenyl(1-methyl-1H-pyrrol-3-yl)methanone | 198126-04-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-chlorophenyl(1-methyl-1H-pyrrol-3-yl)methanone
• 英文别名: (2-Chlorophenyl)-(1-methylpyrrol-3-yl)methanone；(2-chlorophenyl)-(1-methylpyrrol-3-yl)methanone
• CAS: 198126-04-4
• 化学式: C₁₂H₁₀ClNO
• 分子量: 219.671
• InChiKey: XVCRDLHCGZSOAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  22
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-甲基吡咯 、 邻氯苯甲酰氯 在 copper(II) ferrite 作用下， 以 neat (no solvent) 为溶剂， 反应 24.0h， 以57%的产率得到2-chlorophenyl(1-methyl-1H-pyrrol-3-yl)methanone
  参考文献：
  名称：

  Catalytic Friedel–Crafts acylation: magnetic nanopowder CuFe2O4 as an efficient and magnetically separable catalyst

  摘要：

  Catalytic regioselective Friedel-Crafts acylation of an array of anisoles/arenes with various acid chlorides using 5-20 mol % of magnetic nanopowder CuFe2O4 is reported. Unlike the conventional Friedel-Crafts reactions, which are catalyzed by moisture sensitive homogeneous catalysts/promoters, the nanopowder CuFe2O4 catalyst is moisture insensitive and the product/ketone-catalyst isolation is easily achieved using the magnetic properties of CuFe2O4. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.01.081

文献信息

• Catalytic Friedel–Crafts acylation: magnetic nanopowder CuFe2O4 as an efficient and magnetically separable catalyst
  作者：Ramarao Parella、Naveen、Amit Kumar、Srinivasarao Arulananda Babu

  DOI：10.1016/j.tetlet.2013.01.081

  日期：2013.3

  Catalytic regioselective Friedel-Crafts acylation of an array of anisoles/arenes with various acid chlorides using 5-20 mol % of magnetic nanopowder CuFe2O4 is reported. Unlike the conventional Friedel-Crafts reactions, which are catalyzed by moisture sensitive homogeneous catalysts/promoters, the nanopowder CuFe2O4 catalyst is moisture insensitive and the product/ketone-catalyst isolation is easily achieved using the magnetic properties of CuFe2O4. (C) 2013 Elsevier Ltd. All rights reserved.