4-(2-aminophenoxy)pyridine | 4870-01-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(2-aminophenoxy)pyridine
• 英文别名: 4-<2-Amino-phenoxy>-pyridin；2-[4]pyridyloxy-aniline；2-[4]Pyridyloxy-anilin；2-(Pyridin-4-yloxy)aniline；2-pyridin-4-yloxyaniline
• CAS: 4870-01-3
• 化学式: C₁₁H₁₀N₂O
• 分子量: 186.213
• InChiKey: NIRPDVZBDYXCSS-UHFFFAOYSA-N

物化性质

• 熔点：
  93 °C
• 沸点：
  314.2±22.0 °C(Predicted)
• 密度：
  1?+-.0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  48.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(2-aminophenoxy)pyridine 在 氘代甲醇 、 sodium methoxide-d3 作用下， 以 氘代二甲亚砜 为溶剂， 生成
  参考文献：
  名称：

  Katritzky, Alan R.; Murugan, Ramiah, Journal of the Chemical Society. Perkin transactions II, 1987, p. 1867 - 1870

  摘要：

  DOI：
• 作为产物：
  描述：

  4-氯吡啶 在 甲醇 、 镍 作用下， 生成 4-(2-aminophenoxy)pyridine
  参考文献：
  名称：

  Jerchel; Jakob, Chemische Berichte, 1959, vol. 92, p. 724,731

  摘要：

  DOI：

文献信息

• Design, synthesis and structure–affinity relationships of aryloxyanilide derivatives as novel peripheral benzodiazepine receptor ligands
  作者：Taketoshi Okubo、Ryoko Yoshikawa、Shigeyuki Chaki、Shigeru Okuyama、Atsuro Nakazato

  DOI：10.1016/j.bmc.2003.10.050

  日期：2004.1

  Since the peripheral benzodiazepine receptor (PBR) has been primarily found as a high-affinity binding site for diazepam in rat kidney, numerous studies of it have been performed. However, the physiological role and functions of PBR have not been fully elucidated. Currently, we presented the pharmacological profile of two high and selective PBR ligands, N-(2,5-dimethoxybenzyl)-N-(4-fluoro-2-phenoxyphenyl)acetamide (7-096, DAA1106) (PBR: IC50 = 0.28 nM) and N-(4-chloro-2-phenoxyphenyl)-N-(2-isopropoxybenzyl)acetamide (7-099, DAA1097) (PBR: IC50=0.92 nM). The compounds are aryloxyanilide derivatives, and identified with known PBR ligands such as benzodiazepine (1, Ro5-4864), isoquinoline (2, PK11195), imidazopyridine (3, Alpidem), and indole (5, FGIN-1-27) derivatives. The aryloxyanilide derivatives, which have been derived by opening the diazepine ring of 1, are a novel class as PBR ligands and have exhibited high and selective affinity for peripheral benzodiazepine receptors (PBRs). These novel derivatives would be useful for exploring the functions of PBR. In this paper, the design, synthesis and structure-affinity relationships of aryloxyanilide derivatives are described. (C) 2003 Elsevier Ltd. All rights reserved.
• Jerchel et al., Chemische Berichte, 1956, vol. 89, p. 2921,2928
  作者：Jerchel et al.

  DOI：——

  日期：——
• KATRITZKY, ALAN R.;MURUGAN, RAMIAH, J. CHEM. SOC. PERKIN TRANS.,(1987) N 12, 1867-1869
  作者：KATRITZKY, ALAN R.、MURUGAN, RAMIAH

  DOI：——

  日期：——