2-hydroxymethyl-2-methyl-butane-1,3-diol | 4855-37-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-hydroxymethyl-2-methyl-butane-1,3-diol
• 英文别名: 2-Hydroxymethyl-2-methyl-butan-1,3-diol；2-(Hydroxymethyl)-2-methylbutane-1,3-diol
• CAS: 4855-37-2
• 化学式: C₆H₁₄O₃
• 分子量: 134.175
• InChiKey: QEAHTUJZOZSKCY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-hydroxymethyl-2-methyl-butane-1,3-diol 在 sodium acetate 作用下， 生成 4-乙酰氧基-3-乙酰氧基甲基-3-甲基-丁-1-烯
  参考文献：
  名称：

  Notes- The Preparation of 2,2-Bis(hydroxymethyl)-2-methyl-3-butene-1-ol and Their Acetates and Nitrates

  摘要：

  DOI：

  10.1021/jo01089a614
• 作为产物：
  描述：

  4-羟基-3-(羟基甲基)-3-甲基-2-丁酮 在 nickel-copper-manganese 作用下， 110.0 ℃ 、19.61 MPa 条件下， 生成 2-hydroxymethyl-2-methyl-butane-1,3-diol
  参考文献：
  名称：

  DE894240

  摘要：

  公开号：

文献信息

• DIACRYLATE-COMPOUND-CONTAINING COMPOSITION AND CURED PRODUCT THEREOF
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：US20170158855A1

  公开（公告）日：2017-06-08

  The present invention relates to a limited composition containing a diacrylate compound represented by general formula (1). In the formula, R denotes a hydrogen atom or a methyl group. The present invention provides a diacrylate-compound-containing composition which provides a cured product having excellent physical properties such as low curing shrinkage, flexibility, resistance to bending, and low curling properties, and which can be used as a photo- or thermal-radical polymerizable composition and a cured product of the composition.

  本发明涉及一种包含通式（1）所代表的双丙烯酸酯化合物的限定组合物。 在该式中，R代表氢原子或甲基基团。 本发明提供了一种含有双丙烯酸酯化合物的组合物，其提供具有优异物理性能的固化产品，如低固化收缩、柔韧性、抗弯曲性和低卷曲性，并且可以用作光或热自由基可聚合组合物和该组合物的固化产品。
• Synthesis and some spectral characteristics of bicyclic phosphate, GABA antagonists.
  作者：Yoshihisa OZOE、Morifusa ETO

  DOI：10.1271/bbb1961.46.411

  日期：——

  Bicyclic phosphates (BPs), GABA antagonists, were prepared by reaction of the corresponding triols with phosphoryl chloride. The triols were obtained by one of the following methods: (a) the Tollens condensation of an aldehyde possessing α-hydrogen atoms with formaldehyde; (b) the basecatalyzed hydroxymethylation of alkylmalonates or α-alkylacetoacetates with paraformaldehyde, followed by reduction; (c) the reduction of diethyl pivaloylmalonate; or (d) the halogenation of pentaerythritol. Some BPs were also derived by modification of the functional groups of BP homologs. The 1H-NMR spectra of 4-substituted BPs showed a characteristic doublet peak due to the endocyclic methylene protons, the shift position of which was affected by the electronic nature of the bridgehead substituent. The mass spectra of the PBs were characterized by peaks due to the loss of CH2O from the ring.

  双环磷酸酯（BPs），即GABA拮抗剂，是通过相应的三醇与磷酰氯反应制备的。这些三醇是通过以下方法之一获得的：（a）具有α氢原子的醛与甲醛的Tollens缩合；（b）以多聚甲醛为反应物的烷基丙二酸酯或α-烷基乙酰乙酸酯的碱催化羟甲基化反应，随后进行还原；（c）二乙基特戊酰基丙二酸酯的还原；或（d）季戊四醇的卤化。一些BPs还可通过BP同系物的官能团修饰得到。4-取代的BPs的1H-NMR谱显示出由于内环亚甲基质子引起的特征双重峰，其位移位置受桥头取代基的电子性质影响。BPs的质谱特征在于环失CH2O的峰。
• A chemo-enzymatic elaboration of a quarternary chiral center: an alternative approach to the side chain of furaquinocin D
  作者：Tomohiro Akeboshi、Yoshikazu Ohtsuka、Takeshi Sugai、Hiromichi Ohta

  DOI：10.1016/s0040-4020(98)00400-1

  日期：1998.6

  these functionalities was achieved by a combination of stereoselective chemical and enzymatic reactions. The reduction of ethyl 2-hydroxymethyl-2-methyl-3-oxobutanoate with excess NaBH4 afforded ester with a high diastereomeric excess. After protecting the primary hydroxy group as TBDMS ether, the optical resolution was achieved by lipase-catalyzed hydrolysis of the corresponding chloroacetate in a highly

  描述了一种新的制备（2 R，3 R）-2-叔丁基二甲基甲硅烷氧基甲基-3-羟基-2-甲基丁酸乙酯的方法，该化合物与呋喃喹啉D的侧链的合成中间体有关。该化合物的特征是四级手性中心和相邻的仲醇，两者均处于立体化学定义的状态，并且这些功能的建立是通过立体选择性化学反应和酶促反应的结合来实现的。用过量的NaBH 4还原2-羟基甲基-2-甲基-3-甲基氧代丁酸乙酯，得到非对映体过量很高的酯。在将伯羟基保护为TBDMS醚后，通过脂肪酶催化的相应氯乙酸酯的水解以高度对映选择性的方式实现了光学拆分。
• PROCESS FOR PRODUCTION OF ZINC TOLUENESULFONATE, ZINC TOLUENESULFONATE, AND PROCESS FOR PRODUCTION OF CARBAMATE
  申请人：Kosumi Kazuhiro

  公开号：US20120259134A1

  公开（公告）日：2012-10-11

  A process for producing zinc toluenesulfonate comprising reacting a zinc compound comprising Zn(OH) 2 with toluenesulfonic acid and/or a salt thereof in the presence of an alcohol having 1 to 20 carbon atoms in total at a temperature higher than 60° C.

  一种制备甲苯磺酸锌的方法，包括在总碳原子数为1至20的醇的存在下，将含有Zn(OH)2的锌化合物与甲苯磺酸和/或其盐在高于60℃的温度下反应。
• INTERMEDIATES FOR THE PREPARATION OF PYRIDIN-2-YL-AMINO-1,2,4-THIADIAZOLE DERIVATIVES
  申请人：Array BioPharma Inc.

  公开号：US20150057448A1

  公开（公告）日：2015-02-26

  Provided are intermediates having the formulas wherein R 2 , R 3 , and L are as defined in the specification, which are useful in the preparation of pyridin-2-yl-amino-1,2,4-thiadiazole derivatives.

  提供了中间体的公式，其中R2，R3和L的定义如规范中所述，这些中间体在制备吡啶-2-基氨基-1,2,4-噻二唑衍生物中很有用。