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(2E,2'E)-1,1'-[4,6-dihydroxy-1,3-phenylene]bis(3-(3,4-dimethoxyphenyl)prop-2-en-1-one) | 32140-74-2

中文名称
——
中文别名
——
英文名称
(2E,2'E)-1,1'-[4,6-dihydroxy-1,3-phenylene]bis(3-(3,4-dimethoxyphenyl)prop-2-en-1-one)
英文别名
(E)-3-(3,4-dimethoxyphenyl)-1-[5-[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]-2,4-dihydroxyphenyl]prop-2-en-1-one
(2E,2'E)-1,1'-[4,6-dihydroxy-1,3-phenylene]bis(3-(3,4-dimethoxyphenyl)prop-2-en-1-one)化学式
CAS
32140-74-2
化学式
C28H26O8
mdl
——
分子量
490.51
InChiKey
SCPVBRXPKINWTP-NXZHAISVSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    722.4±60.0 °C(Predicted)
  • 密度:
    1.280±0.06 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    5.7
  • 重原子数:
    36
  • 可旋转键数:
    10
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.14
  • 拓扑面积:
    112
  • 氢给体数:
    2
  • 氢受体数:
    8

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

点击查看最新优质反应信息

文献信息

  • Structure-activity relationships in flavonoids 4. Vinylogous chalcones and metadichalcones
    作者:é. T. Oganesyan、A. V. Simonyan、V. S. Cherevatyi
    DOI:10.1007/bf00763669
    日期:1988.9
  • Jayasimha Reddy R., Ashok D., Sarma P. N., Indian J. Chem. B, 32 (1993) N 3, S 404-406
    作者:Jayasimha Reddy R., Ashok D., Sarma P. N.
    DOI:——
    日期:——
  • Bis-chalcone analogues as potent NO production inhibitors and as cytotoxic agents
    作者:M. Vijaya Bhaskar Reddy、Yuh-Chiang Shen、Emika Ohkoshi、Kenneth F. Bastow、Keduo Qian、Kuo-Hsiung Lee、Tian-Shung Wu
    DOI:10.1016/j.ejmech.2011.10.026
    日期:2012.1
    Chalcones have a distinctive 1,3-diarylpropenone skeleton and exert numerous biological effects. Using a one-step Claisen-Schmidt condensation, we synthesized eleven bis-chalcones (3-13) and three acetyl chalcones (14-16) from substituted aldehydes and diacetylresorcinol. The compounds were tested for in vitro cytotoxic activity against four human cancer cell lines (A549, DU145, KB, and KB-VIN) and inhibition of NO production in lipopolysaccharide (LPS)-activated microglial cells. Among them, four compounds (3, 5, 6, and 13) showed significant cytotoxic activity with EC50 values ranging from 1.57 to 514 mu M, and seven compounds (3, 5-8, 10, and 13) displayed potent anti-inflammatory activity by inhibiting NO production with IC50 values ranging from 0.95 to 8.65 mu M. A mechanism of action study of active compounds 6 and 7 discovered that these compounds down-regulated iNOS expression by inhibiting p65 NF-kappa B activation/nuclear translocation due to prevention of ham degradation. Structure-activity relationship (SAR) findings are also discussed. Crown Copyright (C) 2011 Published by Elsevier Masson SAS. All rights reserved.
  • Reddy, R Jayasimha; Ashok, D; Sarma, P N, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1993, vol. 32, # 3, p. 404 - 406
    作者:Reddy, R Jayasimha、Ashok, D、Sarma, P N
    DOI:——
    日期:——
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