(1,2-dimethyl-propyl)-vinyl ether | 41048-38-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1,2-dimethyl-propyl)-vinyl ether
• 英文别名: 2-Methyl-3-vinyloxy-butan；(1,2-Dimethyl-propyl)-vinyl-aether；Methylisopropylcarbinol-vinylaether；2-Ethenoxy-3-methylbutane
• CAS: 41048-38-8
• 化学式: C₇H₁₄O
• 分子量: 114.188
• InChiKey: FTHQFVMSQQIXHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-甲基-2-丁醇 、 乙炔 在 alkali 作用下， 生成 (1,2-dimethyl-propyl)-vinyl ether
  参考文献：
  名称：

  DE745030

  摘要：

  公开号：

文献信息

• METHOD FOR PRODUCING HOMOPOLYMER OR RANDOM COPOLYMER OF HYDROXYL GROUP-CONTAINING VINYL ETHER
  申请人：MARUZEN PETROCHEMICAL CO., LTD.

  公开号：US20150005467A1

  公开（公告）日：2015-01-01

  [Object] To provide a method of producing a homopolymer or random copolymer of hydroxyl group-containing vinyl ether simply and conveniently as well as efficiently. [Means for solving problem] A method of producing a homopolymer or random copolymer of hydroxyl group-containing vinyl ether according to the present invention comprises the step of polymerizing a monomer component comprising at least one hydroxyl group-containing vinyl ether using an oil-soluble radical polymerization initiator in the absence or presence of a solvent.

  【目标】提供一种简单、方便和高效的生产含羟基乙烯醚同聚物或随机共聚物的方法。 【解决问题的方法】根据本发明，生产含羟基乙烯醚同聚物或随机共聚物的方法包括以下步骤：使用油溶性自由基聚合引发剂，在有机溶剂存在或不存在的情况下，聚合至少含有一种羟基乙烯醚单体组分。
• ALKYNE-, AZIDE- AND TRIAZOLE-CONTAINING FLAVONOIDS AS MODULATORS FOR MULTIDRUG RESISTANCE IN CANCERS
  申请人：The Hong Kong Polytechnic University

  公开号：US20150011513A1

  公开（公告）日：2015-01-08

  A triazole bridged flavonoid dimer compound library was efficiently constructed via the cycloaddition reaction of a series of flavonoid-containing azides (Az 1-15) and alkynes (Ac 1-17). These triazole bridged flavonoid dimers and their precursor alkyne- and azide-containing flavonoids were screened for their ability to modulate multidrug resistance (MDR) in P-gp-overexpressed cell line (LCC6MDR), MRP1-overexpressed cell line (2008/MRP1) and BCRP-overexpressed cell line (HEK293/R2 and MCF7-MX100). Generally, they displayed very promising MDR reversal activity against P-gp-, MRP1- and BCRP-mediated drug resistance. Moreover, they showed different levels of selectivity for various transporters. Overall, they can be divided into mono-selective, dual-selective and multi-selective modulators for the P-gp, MRP1 and BCRP transporters. The EC50 values for reversing paclitaxel resistance (141-340 nM) of LCC6MDR cells, DOX (78-590 nM) and vincristine (82-550 nM) resistance of 2008/MRP1 cells and topotecan resistance (0.9-135 nM) of HEK293/R2 and MCF7-MX100 cells were at nanomolar range. Importantly, a number of compounds displayed EC50 at or below 10 nM in BCRP-overexpressed cell lines, indicating that these bivalent triazoles more selectively inhibit BCRP transporter than the P-gp and MRP1 transporters. Most of the dimers are notably safe MDR chemosensitizers as indicated by their high therapeutic index values.

  通过一系列含有三唑桥联类黄酮二聚物的合成，使用环加成反应，利用一系列含有黄酮基团的叠氮化物（Az1-15）和炔烃（Ac1-17）构建了一个高效的化合物库。这些三唑桥联的类黄酮二聚体及其前体炔基和叠氮基类黄酮被筛选，以评估它们对过表达P-gp的细胞系（LCC6MDR）、MRP1过表达的细胞系（2008/MRP1）和BCRP过表达的细胞系（HEK293/R2和MCF7-MX100）调节多药耐药性（MDR）的能力。总体而言，它们展现了极具前景的P-gp、MRP1和BCRP介导的药物耐药性的MDR逆转活性。此外，它们显示出对各种转运体的不同程度的选择性。总体而言，它们可以分为单选择性、双选择性和多选择性的P-gp、MRP1和BCRP转运体调节剂。对于LCC6MDR细胞的紫杉醇耐药性（141-340 nM）、2008/MRP1细胞的DOX（78-590 nM）和长春新碱（82-550 nM）耐药性以及HEK293/R2和MCF7-MX100细胞的拓扑替康耐药性（0.9-135 nM），它们的EC50值处于纳摩尔范围。重要的是，许多化合物在BCRP过表达的细胞系中显示出EC50值在或低于10 nM，表明这些双价三唑更有选择性地抑制BCRP转运体而不是P-gp和MRP1转运体。大多数二聚体的治疗指数值非常高，表明它们是非常安全的MDR化疗敏感剂。
• Polymer composition and core-shell elastomer used therefor
  申请人：MITSUI PETROCHEMICAL INDUSTRIES, LTD.

  公开号：EP0671433A1

  公开（公告）日：1995-09-13

  A polymer composition comprising [A] a polymer selected from a copolymer of α-olefin having at least 2 carbon atoms and a specific cyclic olefin, a ring-opening polymer of said specific cyclic olefin and a hydroganted, ring-opening polymer thereof and [B] a core-shell elastomer containing 40 to 85 parts of weight of a core component which comprises a styrene-butadiene copolymer and 15 to 60 parts by weight of a shell component which comprises a copolymer of an acrylate or methacrylate having a specific cyclic structure, a monovinyl aromatic monomer, other monovinyl monomer and a plyfunctional monomer. This polymer composition is excellent in transparency and impact resistance.

  一种聚合物组合物，包括[A]选自至少有 2 个碳原子的α-烯烃和特定环状烯烃的共聚物、所述特定环状烯烃的开环聚合物和氢化开环聚合物的聚合物，以及[B]一种芯壳弹性体，其中芯部组分的重量占 40 至 85%，包括苯乙烯-丁二烯共聚物，芯部组分的重量占 15 至 60%、B]芯壳弹性体，其中芯组分的重量占 40 至 85%，由苯乙烯-丁二烯共聚物组成；壳组分的重量占 15 至 60%，由具有特定环状结构的丙烯酸酯或甲基丙烯酸酯、单乙烯基芳香族单体、其他单乙烯基单体和层功能单体的共聚物组成。这种聚合物组合物具有出色的透明度和抗冲击性。
• METHOD FOR PRODUCING HOMOPOLYMER OR RANDOM COPOLYMER OF HYDROXYL GROUP-CONTAINING VINYL ETHER
  申请人：Maruzen Petrochemical Co., Ltd.

  公开号：EP2816065A1

  公开（公告）日：2014-12-24

  [Object] To provide a method of producing a homopolymer or random copolymer of hydroxyl group-containing vinyl ether simply and conveniently as well as efficiently. [Means for solving problem] A method of producing a homopolymer or random copolymer of hydroxyl group-containing vinyl ether according to the present invention comprises the step of polymerizing a monomer component comprising at least one hydroxyl group-containing vinyl ether using an oil-soluble radical polymerization initiator in the absence or presence of a solvent.

  [目的] 提供一种简单、方便、高效地生产含羟基乙烯基醚均聚物或无规共聚物的方法。 [解决问题的方法] 根据本发明生产含羟基乙烯基醚均聚物或无规共聚物的方法包括以下步骤：在无溶剂或有溶剂的情况下，使用油溶性自由基聚合引发剂聚合包含至少一种含羟基乙烯基醚的单体组分。
• DE745030
  申请人：——

  公开号：——

  公开（公告）日：——