1-methoxy-2,4-dimethyl-pentan-3-one | 3212-66-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-methoxy-2,4-dimethyl-pentan-3-one
• 英文别名: 1-Methoxy-2,4-dimethylpentan-3-one
• CAS: 3212-66-6
• 化学式: C₈H₁₆O₂
• 分子量: 144.214
• InChiKey: IWDSQTANSHRJEQ-UHFFFAOYSA-N

物化性质

• 沸点：
  183.3±13.0 °C(Predicted)
• 密度：
  0.874±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,4-二甲基-3-戊酮 在 2,3,5-三甲基吡啶 、 溴 作用下， 以 甲醇 、 氯仿 为溶剂， 生成 1-methoxy-2,4-dimethyl-pentan-3-one
  参考文献：
  名称：

  The Effect of Solvent Change on the Favorskii Rearrangement of α-Halo Ketones¹

  摘要：

  DOI：

  10.1021/jo01020a016

文献信息

• O-LINKED GLYCOSYLATION USING N-ACETYLGLUCOSAMINYL TRANSFERASES
  申请人：DeFrees Shawn

  公开号：US20110177029A1

  公开（公告）日：2011-07-21

  The present invention provides covalent conjugates between a polypeptide and a modifying group, such as a water-soluble polymer (e.g., PEG). The amino acid sequence of the polypeptide includes one or more O-linked glycosylation sequence, each being a substrate for a GIcNAc transferase. The modifying group is covalently linked to the polypeptide via a glycosyl-linking group interposed between and covalently linked to both the polypeptide and the modifying group. In one embodiment, a glucosamine linking group is directly attached to an amino acid residue of the O-linked glycosylation sequence. The invention further provides methods of making polypeptide conjugates. The present invention also provides non-naturally occurring polypeptides that include at least one O-linked linked glycosylation sequence of the invention, wherein each glycosylation sequence is a substrate for a GIcNAc transferase. The invention further provides pharmaceutical compositions that include a polypeptide conjugate of the invention.

  本发明提供了一种多肽和修饰基团（例如PEG）之间的共价结合物。多肽的氨基酸序列包括一个或多个O-连接的糖基化序列，每个序列都是GIcNAc转移酶的底物。通过连接在多肽和修饰基团之间并与两者共价连接的糖基连接基团，将修饰基团共价连接到多肽上。在一种实施方式中，葡萄糖胺连接基团直接连接到O-连接的糖基化序列的氨基酸残基上。本发明还提供制备多肽共轭物的方法。本发明还提供了至少包括本发明中的O-连接的糖基化序列之一的非自然多肽，其中每个糖基化序列都是GIcNAc转移酶的底物。本发明还提供包括本发明的多肽共轭物的制药组合物。
• One pot desialylation and glycopegylation of therapeutic peptides
  申请人：DeFrees Shawn

  公开号：US20070105755A1

  公开（公告）日：2007-05-10

  The present invention provides conjugates between peptides and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.
• Glycopegylated Erythropoietin
  申请人：DeFrees Shawn

  公开号：US20070254834A1

  公开（公告）日：2007-11-01

  The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.
• Glycopegylated Granulocyte Colony Stimulating Factor
  申请人：Defrees Shawn

  公开号：US20070254836A1

  公开（公告）日：2007-11-01

  The present invention provides conjugates between Granulocyte Colony Stimulating Factor and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.
• Glycopegylated Follicle Stimulating Hormone
  申请人：DeFrees Shawn

  公开号：US20080015142A1

  公开（公告）日：2008-01-17

  The present invention provides conjugates between follicle stimulating hormone and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.