灭幼脲 | 35409-97-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 灭幼脲
• 中文别名: 一氯苯隆；除幼脲；苏脲一号；1-邻氯苯甲酰基-3-(4-氯苯基)脲；灭幼脲三号；灭幼脲Ⅱ号；三氯脲；N-(2,6-二氯苯甲酰)-N-(4-氯苯基)脲
• 英文名称: N-(2,6-dichlorobenzoyl)-N'-(4-chlorophenyl)-urea
• 英文别名: N-(2,6-dichlorobenzoyl)-N’-(4-chlorophenyl)urea；N-(2,6-Dichlorobenzoyl)-N'-(4-chlorophenyl)urea；1-(2,6-dichlorobenzoyl)-3-(4-chlorophenyl)urea；N-(2,6-dichlorobenzoyl)-N'-(4-chlorophenyl) urea；1-(4-Chlorphenyl)-3-(2,6-dichlorbenzoyl)-harnstoff；1-(4-Chlorophenyl)-3-(2,6-dichlorobenzoyl)urea；2,6-dichloro-N-[(4-chlorophenyl)carbamoyl]benzamide
• CAS: 35409-97-3
• 化学式: C₁₄H₉Cl₃N₂O₂
• 分子量: 343.597
• InChiKey: BTYQXKURSPAXLT-UHFFFAOYSA-N

物化性质

• 密度：
  1.516±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  灭幼脲 、 sodium methylate 以 甲醇 为溶剂， 生成 2,6-二氯苯甲酸甲酯 、 4-氯苯基脲
  参考文献：
  名称：

  Kavalek, Jaromir; Kacetl, Lubomir; Kavalkova, Marcela, Collection of Czechoslovak Chemical Communications, 1989, vol. 54, # 5, p. 1363 - 1369

  摘要：

  DOI：
• 作为产物：
  描述：

  对氯苯胺 、 (2,6-二氯苯甲酰基)-硫代亚氨酸二甲酯 在 溶剂黄146 作用下， 反应 6.0h， 以75%的产率得到灭幼脲
  参考文献：
  名称：

  Richter, Monika; Richter, Wolfgang; Pallas, Manfred, Zeitschrift fur Chemie, 1989, vol. 29, # 6, p. 204 - 205

  摘要：

  DOI：

文献信息

• Substituted benzoyl ureas
  申请人：U.S. Philips Corporation

  公开号：US03933908A1

  公开（公告）日：1976-01-20

  New organic compounds derived from urea or thiourea, insecticidal preparations on the basis of the new substances and methods of producing the substances.

  新的有机化合物，来自尿素或硫脲，基于这些新物质的杀虫制剂以及制造这些物质的方法。
• Insecticidal ureas and thioureas
  申请人：Duphar International Research B.V.

  公开号：US04920135A1

  公开（公告）日：1990-04-24

  Certain organic compounds derived from urea or thiourea having insecticidal activity and methods of their preparation are disclosed. The compounds according to the invention have been found to interfere with the mechanism of metamorphoses which occurs in insects. Hence, the substances according to the invention are specifically active against insects. Owing to this specificity and because of the absence of phytotoxicity effects, the compounds of this invention are of prime importance.

  本发明揭示了从尿素或硫脲衍生的某些有杀虫活性的有机化合物及其制备方法。根据本发明，发现这些化合物能够干扰昆虫发生的变态机制，因此这些物质对昆虫具有特异性活性。由于这种特异性和无植物毒性的影响，本发明的化合物具有重要意义。
• Insecticidal 2,6-dihalobenzoyl urea derivatives
  申请人：U.S. Philips Corporation

  公开号：US04166124A1

  公开（公告）日：1979-08-28

  New 2,6-dihalobenzoyl urea derivatives and their use as insecticides.

  新的2,6-二卤苯甲酰脲衍生物及其作为杀虫剂的用途。
• Certain substituted benzoyl urea insecticides
  申请人：U.S. Philips Corporation

  公开号：US03989842A1

  公开（公告）日：1976-11-02

  Organic compounds derived from urea or thiourea are used as active ingredients in insecticidal compositions.

  从尿素或硫脲衍生的有机化合物被用作杀虫剂组合物的活性成分。
• Organic compounds derived from urea or thiourea
  申请人：Duphar International Research B.V.

  公开号：US05245071A1

  公开（公告）日：1993-09-14

  Compounds of the formula ##STR1## wherein A is a hydrogen atom, a halogen atom, a methyl group, or a methoxy group; B is a hydrogen atom, a halogen atom, a methyl group, or a methoxy group, with the proviso that A and B ar not both a hydrogen atom; X and Y each are an oxygen atom or a sulfur atom; R is a hydrogen atom, an alkyl group, a hydroxy group, an alkoxy group, an alkoxymethyl group, an acyl group, or an alkoxycarbonyl group; R.sub.1 is a hydrogen atom, an alkyl group, a halogen substituted alkyl group, an alkoxy substituted alkyl group, an alkylthio substituted alkyl group, a cyano substituted alkyl group, a 1-cycloalkenyl group, a benzyl group, a halogen substituted benzyl group, a hydroxy group, an alkoxy group, an acyl group, an alkoxycarbonyl group, an alkoxythiocarbonyl group, an alkylsulfonyl group, or a phenylsulfonyl group, while furthermore R and R.sub.1 together with the group ##STR2## indicated in the above formula may form a ring system; and R.sub.2 is a substituted or non-substituted phenyl group or a pyridyl group that may be substituted with halogen, with nitro, with cyano, or with halogenated alkyl. The compounds have strong insecticidal activity against a wide variety of insects and function according to a unique mechanism. Specifically, the compounds are active against insects in the larval stage and are absorbed by the larva via its stomach to interfere with the mechanism of metamorphoses that occurs in insects.

  公式为## STR1 ##的化合物，其中A为氢原子、卤素原子、甲基基团或甲氧基基团；B为氢原子、卤素原子、甲基基团或甲氧基基团，但A和B不同时为氢原子；X和Y分别为氧原子或硫原子；R为氢原子、烷基、羟基、烷氧基、烷氧甲基基团、酰基或烷氧羰基基团；R.sub.1为氢原子、烷基、卤素取代烷基、烷氧取代烷基、烷硫取代烷基、氰基取代烷基、1-环己烯基、苄基、卤素取代苄基、羟基、烷氧基、酰基、烷氧羰基、烷氧硫酰基、烷基磺酰基或苯基磺酰基，而且R和R.sub.1连同上述公式中指示的基团## STR2 ##可以形成一个环系；R.sub.2为取代或非取代苯基或吡啶基，可以用卤素、硝基、氰基或卤代烷基取代。这些化合物对各种昆虫具有强烈的杀虫活性，并根据独特的机制发挥作用。具体来说，这些化合物对幼虫阶段的昆虫具有活性，并被幼虫通过其胃吸收，干扰昆虫发生的变态机制。