(+/-)-2-cyclohexyl-butan-2-ol | 33204-54-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (+/-)-2-cyclohexyl-butan-2-ol
• 英文别名: 2-Cyclohexyl-butanol-(2)；2-Cyclohexyl-2-butanol；2-Cyclohexylbutan-2-ol
• CAS: 33204-54-5；58977-31-4；115921-18-1
• 化学式: C₁₀H₂₀O
• 分子量: 156.268
• InChiKey: ICWUMBNYENCDOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (+/-)-2-cyclohexyl-butan-2-ol 生成 (+/-)-3,5-dinitro-benzoic acid-(1-cyclohexyl-1-methyl-propyl ester)
  参考文献：
  名称：

  Studies in Stereochemistry. XXIX. Neighboring Hydrogen Participation in Ionization to Give Ethylene Protonium Ions as Intermediates in the Wagner-Meerwein Rearrangement¹

  摘要：

  DOI：

  10.1021/ja01520a035
• 作为产物：
  描述：

  2-cyclohexylbut-3-en-2-ol 在 ruthenium palladium 氢气 作用下， 以 丙醇 为溶剂， 生成 (+/-)-2-cyclohexyl-butan-2-ol
  参考文献：
  名称：

  Karavanov, A. N.; Gryaznov, V. M.; Batyrev, I. G., Russian Journal of Physical Chemistry, 1995, vol. 69, # 5, p. 739 - 743

  摘要：

  DOI：

文献信息

• ACID-LABILE ESTER MONOMER HAVING SPIROCYCLIC STRUCTURE, POLYMER, RESIST COMPOSITION, AND PATTERNING PROCESS
  申请人：Kinsho Takeshi

  公开号：US20100304295A1

  公开（公告）日：2010-12-02

  An acid-labile ester monomer of spirocyclic structure has formula (1) wherein Z is a monovalent group having a polymerizable double bond, X is a divalent group which forms a cyclopentane, cyclohexane or norbornane ring, R 2 is H or monovalent hydrocarbon, R 3 and R 4 are H or monovalent hydrocarbon, or R 3 and R 4 , taken together, stand for a divalent group which forms a cyclopentane or cyclohexane ring, and n is 1 or 2. A polymer obtained from the acid-labile ester monomer has so high reactivity in acid-catalyzed elimination reaction that the polymer may be used to formulate a resist composition having high resolution.

  一种酸敏感酯单体具有螺环结构，其化学式如下（1），其中Z是具有可聚合双键的一价基团，X是形成环戊烷、环己烷或诺邦烷环的二价基团，R2是H或一价碳氢基团，R3和R4是H或一价碳氢基团，或者R3和R4一起表示形成环戊烷或环己烷环的二价基团，n为1或2。从酸敏感酯单体获得的聚合物在酸催化消除反应中具有很高的反应性，因此可以用于制备具有高分辨率的抗蚀组合物。
• [EN] PYRIDO[3,4-B]INDOLES AND METHODS OF USE<br/>[FR] PYRIDO[3,4-B]INDOLES ET LEURS MÉTHODES D'UTILISATION
  申请人：MEDIVATION TECHNOLOGIES INC

  公开号：WO2011038163A1

  公开（公告）日：2011-03-31

  This disclosure relates to new heterocyclic compounds that may be used to modulate a histamine receptor in an individual. Pyrido[3,4-b]indoles are described, as are pharmaceutical compositions comprising the compounds and methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

  这份披露涉及可用于调节个体组织中组胺受体的新杂环化合物。描述了吡啶并[3,4-b]吲哚，以及包含这些化合物的药物组合物和使用这些化合物进行各种治疗应用的方法，包括治疗认知障碍、精神障碍、神经递质介导的障碍和/或神经障碍。
• THIENOPYRAZOLES
  申请人：JURCAK John Gerard

  公开号：US20100056514A1

  公开（公告）日：2010-03-04

  Thienopyrazoles, their preparation, pharmaceutical compositions comprising these compounds, and their pharmaceutical uses in the treatment of disease states capable of being modulated by the inhibition of the protein kinases, in particular interleukin-2 inducible tyrosine kinase (ITK).

  Thienopyrazoles，其制备方法，包含这些化合物的制药组合物以及它们在治疗能够被蛋白激酶抑制调节的疾病状态中的制药用途，特别是白细胞介素-2诱导的酪氨酸激酶（ITK）的抑制。
• 4-FLUORO-4-ARYLPIPERDIN-1-YL DERIVATIVES AS MU OPIOID FUNCTION MODERATORS
  申请人：Fairfax David J.

  公开号：US20130045165A1

  公开（公告）日：2013-02-21

  4-Fluoro-4-phenylpiperidin- 1 -yl μ antagonists of general structure as well as pharmaceutical compositions comprising compounds of formula I, are disclosed. These compounds and compositions are useful as treatments of conditions or diseases associated with binding opioid receptors including pain, obesity, hyperalgesia, inflammation, osteoarthritis, drug addiction, and cancer. These compounds and compositions are also useful as treatments for tardive dyskinesia.

  本发明涉及一种通用结构的4-氟-4-苯基哌啶-1-基μ拮抗剂，以及包含式I化合物的制药组合物。这些化合物和组合物可用于治疗与结合阿片受体有关的疾病或症状，包括疼痛、肥胖症、高痛敏性、炎症、骨关节炎、药物成瘾和癌症。这些化合物和组合物还可用于治疗迟发性运动障碍。
• PYRIDO [4,3-B] INDOLE AND PYRIDO [3,4-B] INDOLE DERIVATIVES AND METHODS OF USE
  申请人：Chakravarty Sarvajit

  公开号：US20130172320A1

  公开（公告）日：2013-07-04

  This disclosure is directed to pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

  本公开涉及吡啶并[4,3-b]吲哚和吡啶并[3,4-b]吲哚衍生物。本公开还提供了包含该化合物的制药组合物，以及使用该化合物治疗各种治疗应用的方法，包括治疗认知障碍、精神障碍、神经递质介导的障碍和/或神经元障碍。