2,11-dimethyl-dodecane-5,8-dione | 54276-98-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,11-dimethyl-dodecane-5,8-dione
• 英文别名: 2,11-Dimethyldodecane-5,8-dione
• CAS: 54276-98-1
• 化学式: C₁₄H₂₆O₂
• 分子量: 226.359
• InChiKey: LARWXUYHVIQRQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  5-甲基-2-己酮 生成 2,11-dimethyl-dodecane-5,8-dione
  参考文献：
  名称：

  三氟甲磺酸铜与木酮烯酸酯和三甲基甲硅烷基烯醇醚的氧化偶合反应合成1,4-二酮

  摘要：

  DOI：

  10.1016/s0040-4039(01)83341-4

文献信息

• Ketone compounds and compositions for cholesterol management and related uses
  申请人：Dasseux Henri Jean-Louis

  公开号：US20070155704A1

  公开（公告）日：2007-07-05

  The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.

  本发明涉及新的酮类化合物、包含酮类化合物的组合物、以及用于治疗和预防心血管疾病、血脂异常、蛋白质异常和葡萄糖代谢紊乱的方法，包括给予含有酮类化合物的组合物。本发明的化合物、组合物和方法还可用于治疗和预防阿尔茨海默病、X综合征、过氧化物酶体增殖物激活受体相关疾病、败血症、血栓性疾病、肥胖症、胰腺炎、高血压、肾脏疾病、癌症、炎症和阳痿。在某些实施例中，本发明的化合物、组合物和方法可与其他治疗药物（如降胆固醇和降血糖药物）联合使用。
• KETONE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES
  申请人：Dasseux Henri Jean-Louis

  公开号：US20070149615A9

  公开（公告）日：2007-06-28

  The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.

  本发明涉及新型酮类化合物、包含酮类化合物的组合物以及用于治疗和预防心血管疾病、脂质代谢异常、蛋白质代谢异常和葡萄糖代谢紊乱的方法，其中包括给予含有酮类化合物的组合物。本发明的化合物、组合物和方法还可用于治疗和预防阿尔茨海默病、X综合征、过氧化物酶体增殖物激活受体相关疾病、败血症、血栓性疾病、肥胖症、胰腺炎、高血压、肾脏疾病、癌症、炎症和阳痿。在某些实施例中，本发明的化合物、组合物和方法可与其他治疗剂（如降胆固醇和降血糖药物）联合治疗。
• Photochemistry of the 1,4-aliphatic diketones
  作者：E. A. Lissi、M. V. Encinas、F. Castaneda、F. A. Olea

  DOI：10.1021/j100440a005

  日期：1980.2
• Kobayashi, Yoshiro; Taguchi, Takeo; Morikawa, Tsutomu, Chemical and pharmaceutical bulletin, 1980, vol. 28, # 1, p. 262 - 267
  作者：Kobayashi, Yoshiro、Taguchi, Takeo、Morikawa, Tsutomu、Tokuno, Etsuko、Sekiguchi, Shoh

  DOI：——

  日期：——
• KOBAYASHI YOSHIRO; TAGUCHI TAKEO; MORIKAWA TSUTOMU; TOKUNO ETSUKO; SEKIGU+, CHEM. AND PHARM. BULL., 1980, 28, NO 1, 262-267
  作者：KOBAYASHI YOSHIRO、 TAGUCHI TAKEO、 MORIKAWA TSUTOMU、 TOKUNO ETSUKO、 SEKIGU+

  DOI：——

  日期：——