Propidium bromide | 72460-87-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Propidium bromide
• 英文别名: 3-(3,8-diamino-6-phenylphenanthridin-5-ium-5-yl)propyl-diethyl-methylazanium;dibromide
• CAS: 72460-87-8
• 化学式: C27H34Br2N4
• 分子量: 574.4
• InChiKey: ZLSOONVQLWLPMF-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.0
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  55.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• COBALT-POLYPYRIDYL COMPLEX FOR TREATMENT OF CANCER, A PHARMACEUTICAL COMPOSITION AND A KIT COMPRISING IT
  申请人：Macau University of Science and Technology

  公开号：US20180050044A1

  公开（公告）日：2018-02-22

  A method for treating a subject suffering from a cancer, in particular a multidrug-resistant cancer includes administrating a cobalt-polypyridyl complex to the subject. A method for suppressing the growth of cancer cells, in particular inducing autophagy of the cancer cells, inducing cell cycle arrest of the cancer cells and/or inhibiting cell invasion of the cancer cells and for specifically targeting cancer cells with multidrug-resistance includes contacting said cancer cells with the cobalt-polypyridyl complex. A pharmaceutical composition and a kit are provided and include the cobalt-polypyridyl complex. Unexpectedly, the cobalt-polypyridyl complex is especially suitable to treat cancer, in particular multidrug-resistant cancer with an exceptionally increased cytotoxic activity towards multidrug-resistant cancer cells.

  一种用于治疗患有癌症的受试者的方法，特别是多药耐药癌症，包括向受试者施用钴-多吡啶基配合物。一种用于抑制癌细胞生长的方法，特别是诱导癌细胞自噬，诱导癌细胞细胞周期停滞和/或抑制癌细胞侵袭，并且专门靶向具有多药耐药性的癌细胞的方法包括将所述癌细胞与钴-多吡啶基配合物接触。提供了一种药物组合物和一个工具包，包括钴-多吡啶基配合物。出人意料的是，钴-多吡啶基配合物特别适用于治疗癌症，特别是对多药耐药癌细胞具有极大的细胞毒活性。
• Uses of formulations of thyroid hormone antagonists and nanoparticulate forms thereof to increase chemosensivity and radiosensitivity in tumor or cancer cells
  申请人：Ordway Research Institute, Inc.

  公开号：EP2662079A1

  公开（公告）日：2013-11-13

  Disclosed are methods of increasing the chemosensitivity of normal and/or chemoresistant tumor or cancer cells using thyroid hormone antagonists and/or nanoparticulate or polymeric forms thereof. Also disclosed are methods of increasing radiosensitivity of normal and/or radioresistant tumor or cancer cells using thyroid hormone antagonists and/or nanoparticulate or polymeric forms thereof.

  公开了使用甲状腺激素拮抗剂和/或其纳米粒子或聚合物形式来增加正常和/或化疗耐药肿瘤或癌细胞的化疗敏感性的方法。还公开了使用甲状腺激素拮抗剂和/或其纳米粒子或聚合物形式来增加正常和/或放射治疗耐药肿瘤或癌细胞的放射敏感性的方法。
• Novel dibenzo[c,h][1,5]naphthyridines and their use as DNA probes
  申请人：INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

  公开号：EP1826210A1

  公开（公告）日：2007-08-29

  The present invention concerns novel dibenzo[c,h][1,5]naphthyridine and their use as DNA probes, as well as the methods for marking DNA using the same.

  本发明涉及新型二苯并[c,h][1,5]萘啉及其作为DNA探针的用途，以及使用相同的方法标记DNA。
• USES OF FORMULATIONS OF THYROID HORMONE ANALOGS AND NANOPARTICULATE FORMS THEREOF TO INCREASE CHEMOSENSIVITY AND RADIOSENSITIVITY IN TUMOR OR CANCER CELLS
  申请人：Davis Paul J.

  公开号：US20120315320A1

  公开（公告）日：2012-12-13

  Disclosed are methods of increasing the chemosensitivity of normal and/or chemoresistant tumor or cancer cells using thyroid hormone analogs and/or nanoparticulate or polymeric forms thereof. Also disclosed are methods of increasing radiosensitivity of normal and/or radioresistant tumor or cancer cells using thyroid hormone analogs and/or nanoparticulate or polymeric forms thereof.

  本发明揭示了使用甲状腺激素类似物及其纳米粒子或聚合物形式，增加正常和/或化疗耐药肿瘤或癌细胞的化疗敏感性的方法。本发明还揭示了使用甲状腺激素类似物及其纳米粒子或聚合物形式，增加正常和/或放射线耐药肿瘤或癌细胞的放射线敏感性的方法。
• NANOPARTICLE AND POLYMER FORMULATIONS FOR THYROID HORMONE ANALOGS, ANTAGONISTS, AND FORMULATIONS AND USES THEREOF
  申请人：Davis Paul J.

  公开号：US20110052715A1

  公开（公告）日：2011-03-03

  Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric nanoparticle form of thyroid hormone agonist, partial agonist or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Nanoparticle forms of thyroid hormone or thyroid hormone analogs as well as uses thereof are also disclosed.

  本发明涉及治疗与血管生成相关的疾病的方法，包括向患者施用有效量的聚合物纳米粒子形式的甲状腺激素激动剂、部分激动剂或其拮抗剂，以促进或抑制患者体内的血管生成。本发明还揭示了甲状腺激素或甲状腺激素类似物的纳米粒子形式以及其用途。