9-(2-naphthoyl)carbazole | 23100-61-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 9-(2-naphthoyl)carbazole
• 英文别名: 9-(naphthalene-2-carbonyl)-carbazole；N-(β-Naphthoyl)-carbazol；Carbazol-9-yl(naphthalen-2-yl)methanone
• CAS: 23100-61-0
• 化学式: C₂₃H₁₅NO
• 分子量: 321.378
• InChiKey: LPDZURDPMMUFSA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  25
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  22
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  9-(2-naphthoyl)carbazole 、 二苯基乙炔 在 silver hexafluoroantimonate 、 silver orthophosphate 、 dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer 、 2,6-二甲基苯甲酸 作用下， 以 1,2-二氯乙烷 为溶剂， 以36 %的产率得到2,3-diphenyl-1H-cyclopenta[b]naphthalen-1-one
  参考文献：
  名称：

  铑（III）催化的[3 + 2]环状利用可回收的咔唑基离去基团合成茚满

  摘要：

  铑（III）催化的9-苯甲酰基咔唑与内部炔烃的环状偶联通过邻位C–H和C–N键断裂而有效进行。该反应提供了直接获得各种取代的茚满酮衍生物的途径。咔唑基离去基团可以容易地回收并再用于制备起始原料。关键字：环空；铑催化剂 C–H键裂解

  DOI：

  10.1246/cl.200884
• 作为产物：
  描述：

  咔唑 、 2-萘甲酸 在 二碳酸二叔丁酯 、 4-(二甲胺基丙基)吡啶 、 三乙胺 作用下， 以 乙腈 为溶剂， 以99 %的产率得到9-(2-naphthoyl)carbazole
  参考文献：
  名称：

  DMAPO/Boc2O 介导的低亲核性 N-杂环与羧酸的一锅法直接 N-酰化

  摘要：

  氮亲核试剂：报道了用羧酸对亲核性较低的氮杂环进行直接N-酰化的一般方法。该方法使用简单、市售的试剂、无金属和用户友好的条件，对含氮亲核试剂和羧酸显示出优异的官能团耐受性和广泛的底物范围。

  DOI：

  10.1002/cctc.202201596

文献信息

• Method of cleaving labile functional groups from chemical compounds
  申请人：Stengele Klaus-Peter

  公开号：US20050170281A1

  公开（公告）日：2005-08-04

  The present invention provides a method of cleaving labile functional groups from molecules by exposure to electromagnetic radiation in which the molecules are contacted with a chemical compound whose triplet state is energetically higher than the triplet state of the labile functional group and are then exposed to electromagnetic radiation, with the labile functional group and the suitable chemical compound having different absorption maxima for electromagnetic radiation. Further, the invention provides a method of manufacturing DNA chips by spatially addressed, light-controlled nucleotide synthesis on solid substrates. In addition, the present invention provides a chemical composition comprising a molecule with a labile functional group and a chemical compound whose triplet state is higher than the triplet state of the labile functional group, with the labile functional group and the chemical compound having different absorption maxima for electromagnetic radiation, and describes the use of the chemical composition in the manufacture of DNA chips.

  本发明提供了一种通过暴露于电磁辐射来裂解分子中的易损官能团的方法，在该方法中，分子与三重态能量高于易损官能团的三重态的化合物接触，然后暴露于电磁辐射，易损官能团和合适的化合物对电磁辐射具有不同的吸收最大值。此外，本发明还提供了一种通过在固体基底上进行空间寻址、光控核苷酸合成来制造 DNA 芯片的方法。此外，本发明还提供了一种化学组合物，该化学组合物包括具有易变官能团的分子和三重态高于易变官能团三重态的化合物，易变官能团和化合物对电磁辐射具有不同的吸收最大值，并描述了该化学组合物在制造 DNA 芯片中的用途。
• A METHOD FOR CLEAVAGE OF LABILE FUNCTIONAL GROUPS FROM CHEMICAL COMPOUNDS
  申请人：Universität Konstanz

  公开号：EP1480927A2

  公开（公告）日：2004-12-01
• A METHOD OF CLEAVING LABILE FUNCTIONAL GROUPS FROM CHEMICAL COMPOUNDS
  申请人：Chemogenix GmbH

  公开号：EP1519941A2

  公开（公告）日：2005-04-06
• Method for cleavage of labile functional groups from chemical compounds
  申请人：Steiner Ulrich

  公开号：US20050255403A1

  公开（公告）日：2005-11-17

  The present invention provides a method for cleavage of labile functional groups from molecules by the action of electromagnetic radiation, wherein the molecules are contacted with a chemical compound whose triplet state is energetically higher than the triplet state of the labile functional group, and are subsequently exposed to electromagnetic radiation. Further, the invention provides a method for preparing DNA chips by spatially addressed, light-controlled nucleotide synthesis on solid substrates, said method comprising the following steps: a) reacting the unprotected terminal 3′ or 5′ hydroxy croup of a nucleoside and/or of a nucleotide arranged on the solid substrate under usual conditions with a photolabile protective group and optionally purifying the reaction product. b) applying a solution, suspension or dispersion of a chemical compound, whose triplet state is energetically higher than the triplet state of the photolabile protective group. to the surface of the carrier, said surface comprising the nucleotides and/or nucleosides modified in step a): c) irradiating, in a spatially selective manner, the surface of the carrier treated in step b) with electromagnetic radiation in the UV/VIS range with simultaneous, spatially selective release of a reactive OH group and subsequently reacting it with a nucleoside and/or nucleotide comprising a 5′ or 3′OH group, said nucleoside and/or nucleotide being further provided with a photolabile functional group. Moreover, the present invention provides a chemical composition comprising a molecule having a labile functional group, as well as a chemical compound whose triplet state is higher than the triplet state of the labile functional group, and it describes the use of the chemical composition for preparing DNA chips.
• US7598019B2
  申请人：——

  公开号：US7598019B2

  公开（公告）日：2009-10-06