ethyl N-[(R)-1,4-dioxaspiro[4.5]dec-2-ylethoxymethyl]-N-(prop-2-en-1-yl)carbamate | 1198108-99-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ethyl N-[(R)-1,4-dioxaspiro[4.5]dec-2-ylethoxymethyl]-N-(prop-2-en-1-yl)carbamate
• 英文别名: ethyl N-[[(3R)-1,4-dioxaspiro[4.5]decan-3-yl]-ethoxymethyl]-N-prop-2-enylcarbamate
• CAS: 1198108-99-4
• 化学式: C₁₇H₂₉NO₅
• 分子量: 327.421
• InChiKey: HDOPCNGTAGBXLZ-GICMACPYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  57.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-[(3S)-1,4-dioxaspiro[4.5]decan-3-yl]-N-prop-2-enylmethanimine 、 焦碳酸二乙酯 以 乙醇 为溶剂， 反应 0.05h， 以44%的产率得到ethyl N-[(R)-1,4-dioxaspiro[4.5]dec-2-ylethoxymethyl]-N-(prop-2-en-1-yl)carbamate
  参考文献：
  名称：

  Microwave-assisted synthesis of α-ethoxycarbamates

  摘要：

  An efficient and reproducible synthesis of various alpha-ethoxycarbamates is described via a microwave heating mode. Compared to the thermal process. the microwave dielectric heating induces a dramatic reduction of the reaction time and the improvement of the yields. The reaction is general since applicable to aromatic and aliphatic aldehydes with various primary amines. Several examples involving chiral aldehydes have also been considered. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.09.023

文献信息

• Microwave-assisted synthesis of α-ethoxycarbamates
  作者：Alexandre Lumbroso、Floris Chevallier、Isabelle Beaudet、Jean-Paul Quintard、Thierry Besson、Erwan Le Grognec

  DOI：10.1016/j.tet.2009.09.023

  日期：2009.11

  An efficient and reproducible synthesis of various alpha-ethoxycarbamates is described via a microwave heating mode. Compared to the thermal process. the microwave dielectric heating induces a dramatic reduction of the reaction time and the improvement of the yields. The reaction is general since applicable to aromatic and aliphatic aldehydes with various primary amines. Several examples involving chiral aldehydes have also been considered. (C) 2009 Elsevier Ltd. All rights reserved.