4-(2-hydroxyethoxy)-2,3-dimethylpyridine N-oxide | 117977-51-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(2-hydroxyethoxy)-2,3-dimethylpyridine N-oxide
• 英文别名: 2-(2,3-dimethyl-1-oxidopyridin-1-ium-4-yl)oxyethanol
• CAS: 117977-51-2
• 化学式: C₉H₁₃NO₃
• 分子量: 183.207
• InChiKey: VFZPTBUQULLVHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  54.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(2-hydroxyethoxy)-2,3-dimethylpyridine N-oxide 在 乙酸酐 作用下， 以 乙醇 为溶剂， 生成 4-(2-acetoxyethoxy)-2-acetoxymethyl-3-methylpyridine
  参考文献：
  名称：

  Pyridine derivatives having anti-ulcerative activity

  摘要：

  可用于预防或治疗消化性溃疡的吡啶衍生物、药物制剂及治疗消化性溃疡的方法。

  公开号：

  US05045552A1
• 作为产物：
  描述：

  2,3-二甲基-4-氯吡啶-N-氧化物 以 乙二醇 为溶剂， 生成 4-(2-hydroxyethoxy)-2,3-dimethylpyridine N-oxide
  参考文献：
  名称：

  Pyridine derivatives having anti-ulcerative activity

  摘要：

  可用于预防或治疗消化性溃疡的吡啶衍生物、药物制剂及治疗消化性溃疡的方法。

  公开号：

  US05045552A1

文献信息

• Preparation of substituted pyridine N-oxide compounds
  申请人：——

  公开号：US20040063957A1

  公开（公告）日：2004-04-01

  A process for preparing substituted pyridine N-oxide compounds of the formula 1 in which R1, R2, R3 and R4 are each H, a carboxyl group or a C 1 -C 12 -alkyl radical which may contain atoms from the group of N, O and S, or R1 and R2 and/or R3 and R4 together may each form an optionally substituted C 4 -C 20 -alkylene radical which may contain atoms from the group of N, O and S, A is benzyl or a (CH 2 ) m group where m may be an integer from 1 to 12, Z 1 and Z 2 are each independently O or S, and Y is H, a C 1 -C 12 -alkyl radical which may optionally contain atoms from the group of N, O and S, a C 6 -C 20 -aryl radical or a C 5 -C 20 -heterocycle, and the radicals may optionally be substituted, or Z 2 and Y together form an optionally substituted ring or ring system, in which case the ring or ring system may contain atoms from the group of N, O and S, from the corresponding 4-halopyridine N-oxide of the formula 2 in which X is chlorine, bromine or iodine, by reacting the compound of the formula (II), in the presence of a phase transfer catalyst and of a base, with a compound of the formula HZ 1 -A-Z 2 -Y  (III) in which Z 1 , Z 2 , A and Y are each as defined above, at a temperature up to the reflux temperature, to give the corresponding substituted pyridine N-oxide compound of the formula (I), and also a process for preparing the compound of the formula (II).

  一种制备取代吡啶N-氧化物化合物的方法，该化合物的公式为1，其中R1、R2、R3和R4分别为H、羧基或可能含有N、O和S的C1-C12烷基基团，或者R1和R2和/或R3和R4可以共同形成一个可选取代的C4-C20烷基基团，该基团可能含有N、O和S的原子，A为苄基或(CH2)m基团，其中m可以是1到12的整数，Z1和Z2各自独立地为O或S，Y为H、C1-C12烷基基团，该基团可以选择地含有N、O和S的原子，C6-C20芳基基团或C5-C20杂环，且基团可以选择性地被取代，或者Z2和Y共同形成一个可选择性取代的环或环系统，此时该环或环系统可以含有N、O和S的原子，从公式2中相应的4-卤代吡啶N-氧化物开始，其中X为氯、溴或碘，通过在相转移催化剂和碱存在下，将公式（II）的化合物与公式HZ1-A-Z2-Y（III）的化合物在回流温度以下的温度下反应，从而得到公式（I）的相应取代吡啶N-氧化物化合物，以及制备公式（II）的化合物的方法。
• Pyridine derivatives, pharmaceutical compositions comprising the same, the use of the same for the manufacture of medicaments having therapeutic or preventative value, and a process for preparing the same
  申请人：Eisai Co., Ltd.

  公开号：EP0786461A1

  公开（公告）日：1997-07-30

  The invention provides pyridine derivatives represented by the general formula: wherein R1 and R2 may be the same or different from each other and each stand for a hydrogen atom, a C1-6 alkyl, C1-6 alkoxy, halogenated C1-6 alkyl, (C1-6 alkoxy) carbonyl or carboxyl group or a halogen atom; X stands for a group represented by the formula: -O-, -S-or (wherein R3 stands for a hydrogen atom or a C1-6 alkyl, phenyl, benzyl or (C1-6 alkoxy)carbonyl group); Z stands for ① a group represented by the general formula:         -0-(CH2)q-R5 wherein q stands for an integer of 1 to 3 and R5 stands for a halogen atom or an (C1-6 alkoxy) carbonyl, aryl or heteroaryl group, ② a group represented by the general formula:         -0-(CH2)r-0-(CH2)s-0-R6 wherein r and s each stand for an integer of 1 to 5 and R6 stands for a hydrogen atom or a C1-6 alkyl group, ③ a group represented by the formula: ④ a group represented by the general formula: wherein t stands for an integer of 0 to 2 and A stands for a group represented by the general formula: (wherein B stands for a group represented by the formula: -NH-, -0- or -S-), a C1-6 aklyl, (C1-6 alkoxy)carbonylmethyl, pyridyl or furyl group or a group represented by the general formula: (wherein R7 stands for a hydrogen atom, a C1-6 alkyl or C1-6 alkoxy group or a halogen atom and w stands for an integer of 0 or 1), ⑤ a group represented by the general formula: wherein R8 stands for an acetoxy or C1-6 alkyl group, n stands for an integer of 0 to 2, m stands for an integer of 2 to 10, and J and K may be the same or different from each other and each stand for a hydrogen atom or a C1-6 alkyl group, and a pharmaceutically acceptable salt thereof. Pharmaceutical compositions comprising these derivatives are also provided, together with the use of the derivatives for the manufacture of medicaments having therapeutic or preventative value in the treatment of peptic ulcers. Processes for preparing such pyridine derivatives are also provided.

  本发明提供了由一般式表示的吡啶衍生物：其中R1和R2可以相同或不同，分别代表氢原子，C1-6烷基，C1-6烷氧基，卤代C1-6烷基，(C1-6烷氧基)羰基或羧基或卤原子；X代表由公式表示的基团：-O-，-S-或（其中R3代表氢原子或C1-6烷基，苯基，苄基或（C1-6烷氧基）羰基）；Z代表①由一般式表示的基团：-0-（CH2）q-R5，其中q为1至3的整数，R5为卤原子或（C1-6烷氧基）羰基，芳基或杂芳基基团，②由一般式表示的基团：-0-（CH2）r-0-（CH2）s-0-R6，其中r和s分别为1至5的整数，R6为氢原子或C1-6烷基基团，③由公式表示的基团：④由一般式表示的基团：其中t为0至2的整数，A代表由一般式表示的基团：（其中B代表- NH-，-0-或-S-表示的基团），C1-6烷基，（C1-6烷氧基）羰基甲基，吡啶基或呋喃基团或由一般式表示的基团：（其中R7代表氢原子，C1-6烷基或C1-6烷氧基基团或卤原子，w代表0或1），⑤由一般式表示的基团：其中R8代表乙酰氧基或C1-6烷基基团，n为0至2的整数，m为2至10的整数，J和K可以相同或不同，分别代表氢原子或C1-6烷基基团，并且其药学上可接受的盐。还提供了包含这些衍生物的制药组合物，以及这些衍生物在制造具有治疗或预防胃溃疡价值的药物方面的用途。还提供了制备这种吡啶衍生物的方法。
• Pyridine derivatives, pharmaceutical compositions comprising the same, the use of the same for the manufacture of medicaments having therapeutic or preventative value, and process for preparing the same
  申请人：Eisai Co., Ltd.

  公开号：EP0654471B1

  公开（公告）日：1998-07-08
• US5045552A
  申请人：——

  公开号：US5045552A

  公开（公告）日：1991-09-03
• US5840910A
  申请人：——

  公开号：US5840910A

  公开（公告）日：1998-11-24