COMPOUNDS AND METHODS FOR INHIBITING NHE-MEDIATED ANTIPORT IN THE TREATMENT OF DISORDERS ASSOCIATED WITH FLUID RETENTION OR SALT OVERLOAD AND GASTROINTESTINAL TRACT DISORDERS
申请人:Charmot Dominique
公开号:US20120263670A1
公开(公告)日:2012-10-18
The present disclosure is directed to compounds and methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure (in particular, congestive heart failure), chronic kidney disease, end-stage renal disease, liver disease, and peroxisome proliferator-activated receptor (PPAR) gamma agonist-induced fluid retention. The present disclosure is also directed to compounds and methods for the treatment of hypertension. The present disclosure is also directed to compounds and methods for the treatment of gastrointestinal tract disorders, including the treatment or reduction of pain associated with gastrointestinal tract disorders.
本公开涉及化合物和方法,用于治疗与液体潴留或盐过载相关的疾病,如心力衰竭(特别是充血性心力衰竭)、慢性肾脏病、终末期肾脏病、肝病和过氧化物酶体增殖物激活受体(PPAR)γ激动剂引起的液体潴留。本公开还涉及化合物和方法,用于治疗高血压。本公开还涉及化合物和方法,用于治疗胃肠道疾病,包括治疗或减轻与胃肠道疾病相关的疼痛。