2-(二甲氨基)-1-(4-氟苯基)乙酮 | 709-23-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-(二甲氨基)-1-(4-氟苯基)乙酮
• 英文名称: 1-(4-fluorophenyl)-2-dimethylamino-ethanone
• 英文别名: α-dimethylamino-4-fluoroacetophenone；2-(Dimethylamino)-1-(4-fluorophenyl)ethanone
• CAS: 709-23-9
• 化学式: C₁₀H₁₂FNO
• mdl: MFCD01052791
• 分子量: 181.21
• InChiKey: VKQHJWXHBISWQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(二甲氨基)-1-(4-氟苯基)乙酮 在 溶剂黄146 、 锌 作用下， 反应 1.0h， 以68%的产率得到4-氟苯乙酮
  参考文献：
  名称：

  锌-乙酸促进α-氨基酮的还原碳-氮键断裂反应

  摘要：

  Scope and limitation of the reductive cleavage reaction of a-aminoketone systems with zinc-acetic acid are described. The carbon-nitrogen bond cleavage reaction was applicable to a wide range of alpha-aminoalkyl aryl ketones possessing various substituents on the aromatic ring. In contrast, a-aminoalkyl alkyl ketones with protons at the alpha'-position or alpha-aminoesters were sluggish to the carbon-nitrogen cleavage reaction.

  DOI：

  10.3987/com-13-s(s)64

文献信息

• Novel alpha-aminoacetophenones as photoinitiators
  申请人：Ciba-Geigy Corporation

  公开号：US05077402A1

  公开（公告）日：1991-12-31

  Compounds of the formula I, II, III and IIIa ##STR1## in which Ar.sup.1 is an unsubstituted or substituted aromatic radical and at least one of the radicals R.sup.1 and R.sup.2 is an alkenyl, cycloalkenyl or arylmethyl group, are effective photoinitiators for photopolymerization of unsaturated compounds. They are particularly suitable for photocuring of pigmented systems.

  式I、II、III和IIIa的化合物##STR1##中，Ar.sup.1是未取代或取代的芳香基团，且至少有一个基团R.sup.1和R.sup.2是烯基、环烯基或芳基甲基基团，对于不饱和化合物的光聚合具有有效的光引发作用。它们特别适用于有色系统的光固化。
• 1,3-dithiolan-2-ylidenes their 1-oxides, pharmaceutical compositions,
  申请人：Ciba-Geigy Corporation

  公开号：US04818765A1

  公开（公告）日：1989-04-04

  The invention relates to the use of ketenethioacetals of the formula ##STR1## in which R.sub.1 represents aryl or heteroaryl, R.sub.2 represents hydrogen, an optionally substituted hydrocarbon radical, heteroaryl, an acyl radical, a group of the formula --S(O).sub.m --R.sub.a, wherein m is 0, 1, or 2 and R.sub.a is an optionally substituted hydrocarbon radical; or optionally functionally modified sulpho, A represents an optionally substituted bivalent aliphatic hydrocarbon radical and n is 0 or 1, and pharmaceutically acceptable salts of such compounds that contain a salt-forming group, for the treatment of liver diseases, respiratory tract diseases and vascular diseases pharmaceutical preparations containing compounds of the formula I and novel compounds of the formula I. The compounds have liver-protecting and immunomodulating properties.

  该发明涉及使用式为##STR1##的烯硫醛缩醛化合物，其中R.sub.1代表芳基或杂环芳基，R.sub.2代表氢、可选择取代的碳氢基团、杂环芳基、酰基基团、--S(O).sub.m --R.sub.a的基团，其中m为0、1或2，R.sub.a为可选择取代的碳氢基团；或可选择功能修饰的磺酸基，A代表可选择取代的二价脂肪烃基，n为0或1，并且包含具有含有盐形成基团的这种化合物的药用盐，用于治疗肝病、呼吸道疾病和血管疾病的制药制剂，其中包含式I的化合物和式I的新化合物。这些化合物具有保护肝脏和免疫调节特性。
• 265. Di-N-substituted 2-halogenoethylamines. Part VI. NN-dialkyl-(or N-alkyl)-2-alkyl(or aryl or arylalkyl) derivatives: synthesis, reactivity, and pharmacology
  作者：N. B. Chapman、D. J. Triggle

  DOI：10.1039/jr9630001385

  日期：——
• CHELATES COMPRISING CHINOID GROUPS AS PHOTOINITIATORS
  申请人：KIMBERLY-CLARK WORLDWIDE, INC.

  公开号：EP1117698B1

  公开（公告）日：2006-04-19
• Dithio compounds, pharmaceutical preparations containing them and their use
  申请人：Zyma SA

  公开号：EP0099329B1

  公开（公告）日：1990-10-31