diethyl methylbenzoylmalonate | 28286-77-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: diethyl methylbenzoylmalonate
• 英文别名: diethyl 2-benzoyl-2-methylmalonate；benzoyl-methyl-malonic acid diethyl ester；Benzoyl-methyl-malonsaeure-diaethylester；diethyl 2-benzoyl-2-methylpropanedioate
• CAS: 28286-77-3
• 化学式: C₁₅H₁₈O₅
• 分子量: 278.305
• InChiKey: NQNLQRUVHXUNRN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  69.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  diethyl methylbenzoylmalonate 以98%的产率得到
  参考文献：
  名称：

  MROCZYK, WIESLAWA, ROCZ. AR POZNANIU. FIZ. CHEM.,(1988) N, C. 79-83

  摘要：

  DOI：
• 作为产物：
  描述：

  sodium diethyl methylmalonate 、 苯甲酰氯 在 乙醚 作用下， 生成 diethyl methylbenzoylmalonate
  参考文献：
  名称：

  Meyer,R.; Lueders, Justus Liebigs Annalen der Chemie, 1918, vol. 415, p. 31,32

  摘要：

  DOI：

文献信息

• Acylation of active methylene compounds via palladium complex-catalyzed carbonylative cross-coupling of organic halides
  作者：Toshi-aki Kobayashi、Masato Tanaka

  DOI：10.1016/s0040-4039(00)85054-6

  日期：1986.1

  New procedures for acylation of active methylene compounds via palladium complex-catalyzed carbonylation of organic halides are disclosed.

  公开了通过钯配合物催化的有机卤化物的羰基化作用，将活性亚甲基化合物酰化的新方法。
• A NEW METHOD FOR ACYLATION OF ENOLATES BY MEANS OF DIALKYL ACYLPHOSPHONATES AS ACYLATING AGENTS
  作者：Mitsuo Sekine、Akiko Kume、Masashi Nakajima、Tsujiaki Hata

  DOI：10.1246/cl.1981.1087

  日期：1981.8.5

  Acylations of various enolates by means of diethyl acylphosphonates were described. For the acylation of acetophenone, lithium bis(trimethylsilyl)amide (LSA) was found to be suitable as the base. The scope and limitation of the benzoylation using diethyl benzoylphosphonates were also described.

  描述了通过酰基膦酸二乙酯对各种烯醇化物的酰化。对于苯乙酮的酰化，发现双（三甲基甲硅烷基）氨基锂（LSA）适合作为碱。还描述了使用苯甲酰膦酸二乙酯进行苯甲酰化的范围和限制。
• Pd-catalyzed carbonylation for the construction of tertiary and quaternary carbon centers with sp3 carbon partners
  作者：Wei Lu、Yang Li、Chao Wang、Dong Xue、Jian-Gang Chen、Jianliang Xiao

  DOI：10.1039/c4ob00568f

  日期：——

  The first examples of a Pd-catalyzed carbonylation of aryl boronic acids with sp3 carbon partners are presented. Various boronic acids were shown to react with 1,3-diesters and 1,3-diketones to afford structurally unique carbonyl compounds. By employing 2-substituted 1,3-diesters, synthetically-challenging quaternary carbon centres were accessed. In total, 42 examples of aryl carbonyl compounds were prepared in moderate to good yields. The catalytic system features the use of a bidentated phosphine ligand and a relatively low CO pressure (5 atm), providing an easy, alternative method for the preparation of triketones.

  展示了使用Pd催化的芳基硼酸与sp3碳伙伴进行羰基化的首个示例。各种硼酸与1,3-二酯和1,3-二酮反应，生成了结构独特的羰基化合物。通过使用2-取代的1,3-二酯，成功获得了合成上具有挑战性的四级碳中心。总共合成了42种芳基羰基化合物，产率中等到良好。该催化系统采用了双联磷配体和相对较低的CO压力（5个大气压），为合成三酮提供了一种简单的替代方法。
• Bleach precursors
  申请人：UNILEVER PLC

  公开号：EP0517482A2

  公开（公告）日：1992-12-09

  A class of malonates having the structure : wherein : m is an integer from 0 to 1 m1 is an integer from 0 to 4 ; R1 is a C1-C20 radical selected from the group consisting of alkyl, cycloalkyl, alkenyl, cycloalkenyl, phenyl, aryl, benzoyl and aroyl radicals, and when m is 0 and m1 is at least 1 then R1 can be hydrogen ; R2 and R3 are radicals selected from the group consisting of C1-C12 alkyl and C5-C12 cycloalkyl radicals ; and R4 is independently selected from the same group as R1 except that R4 is other than hydrogen, benzoyl and aroyl radicals, has been identified as providing effective bleach precursors. These precursors are employed in conjunction with a peroxygen compound.

  一类丙二酸盐，具有......结构： 其中： m 是 0 至 1 的整数 m1 是 0 至 4 的整数； R1 是 C1-C20 自由基，选自由烷基、环烷基、烯基、环烯基、苯基、芳基、苯甲酰 基和芳基组成的组，当 m 为 0 且 m1 至少为 1 时，R1 可以是氢； R2 和 R3 是选自 C1-C12 烷基和 C5-C12 环烷基的自由基；以及 R4 独立地选自与 R1 相同的基团，但 R4 不是氢、苯甲酰基和芳基。这些前体与过氧化合物一起使用。
• MROCZYK, WIESLAWA, ROCZ. AR POZNANIU. FIZ. CHEM.,(1988) N, C. 79-83
  作者：MROCZYK, WIESLAWA

  DOI：——

  日期：——