Dicyclohexyl but-2-enedioate | 135607-72-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Dicyclohexyl but-2-enedioate
• CAS: 135607-72-6
• 化学式: C₁₆H₂₄O₄
• 分子量: 280.364
• InChiKey: BLKQQTCUGZJWLN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Dicyclohexyl but-2-enedioate 、 1-乙酰基-2-苯基肼 在 Cp*Rh(CH₃CN)₃(SbF₆)₂ 、 sodium acetate 、 silver carbonate 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 3.0h， 以76%的产率得到dicyclohexyl 1H-indole-2,3-dicarboxylate
  参考文献：
  名称：

  通过铑催化的芳基肼与马来酸酯的CH环化反应合成1H-吲哚-2,3-二羧酸酯。

  摘要：

  这项工作描述了通过C–H活化的1 H-吲哚-2,3-二羧酸酯的一步合成。在添加剂NaOAc和氧化剂Ag 2 CO 3的存在下，铑催化的串联C–H活化和2-乙酰基-1-苯基肼与马来酸酯的环合反应顺利进行，并产生了相应的吲哚衍生物1 H-吲哚-2,3-二羧酸盐，令人满意的好收率。苯环上可耐受各种有用的官能团，包括卤素原子（F，Cl，Br和I）和甲氧羰基。

  DOI：

  10.1021/acs.joc.0c01727
• 作为产物：
  描述：

  富马酸 、 环己醇 在 N-甲基吗啉 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以3%的产率得到Cyclohexyl fumarate
  参考文献：
  名称：

  Structure–activity relationships of trans-substituted-propenoic acid derivatives on the nicotinic acid receptor HCA2 (GPR109A)

  摘要：

  Nicotinic acid (niacin) has been used for decades as an antidyslipidemic drug in man. Its main target is the hydroxy-carboxylic acid receptor HCA2 (GPR109A), a G protein-coupled receptor. Other acids and esters such as methyl fumarate also interact with the receptor, which constituted the basis for the current study. We synthesized a novel series of substituted propenoic acids, such as fumaric acid esters, fumaric acid amides and cinnamic acid derivatives, and determined their affinities for the HCA2 receptor. We observed a rather restricted binding pocket on the receptor with trans-cinnamic acid being the largest planar ligand in our series with appreciable affinity for the receptor. Molecular modeling and analysis of the structure-activity relationships in the series suggest a planar trans-propenoic acid pharmacophore with a maximum length of 8 angstrom and out-of-plane orientation of the larger substituents. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.11.091

文献信息

• Compound having silsesquioxane skeleton and its polymer
  申请人：Inagaki Jyun-ichi

  公开号：US20050009982A1

  公开（公告）日：2005-01-13

  The present invention relates to a compound represented by Formula (1) and a polymer obtained using the compound: wherein R 1 is phenyl which may have substituents, Q 1 is hydrogen, halogen, alkyl having 1 to 10 carbon atoms, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclohexenyl or phenyl in which optional hydrogen may be replaced by halogen or alkyl having 1 to 5 carbon atoms, and Q 2 is a group represented by Formula (2) wherein the code < represents a bonding point with silicon, l, m, n and p are independently 0, 1, 2 or 3, A 1 to A 4 are independently a single bond, 1,4-cyclohexylene, 1,4-cyclohexenylene, a condensed ring group having 6 to 10 carbon atoms which is a divalent group, or 1,4-phenylene, Z 0 to Z 3 are independently a single bond, —CH═CR—, —C≡C—, —COO—, —OCO—, or alkylene having 1 to 20 carbon atoms, and Z 4 is a single bond, —CH═CH—, —C≡C—, —COO—, —OCO—, or alkylene having 1 to 20 carbon atoms. And Y 1 in Formula (1) is the group defined in Claim 1.

  本发明涉及一种由式（1）表示的化合物和使用该化合物获得的聚合物：其中R1是苯基，可能具有取代基；Q1是氢、卤素、具有1至10个碳原子的烷基、环丙基、环丁基、环戊基、环己基、环己烯基或苯基，其中可选的氢原子可被卤素或具有1至5个碳原子的烷基取代；Q2是由式（2）表示的基团，其中代码<表示与硅的连接点，l、m、n和p独立地为0、1、2或3，A1至A4独立地为单键、1,4-环己亚基、1,4-环己烯亚基、具有6至10个碳原子的缩合环基团，为二价基团，或1,4-苯亚基，Z0至Z3独立地为单键、—CH═CR—、—C≡C—、—COO—、—OCO—或具有1至20个碳原子的烷基，Z4为单键、—CH═CH—、—C≡C—、—COO—、—OCO—或具有1至20个碳原子的烷基。式（1）中的Y1是权利要求1中定义的基团。
• Durable coating compositions containing novel aspartic amine compounds
  申请人：Lenges Peter Christian

  公开号：US20060155148A1

  公开（公告）日：2006-07-13

  A coating composition comprising a binder of a. polyisocyanate crosslinking agent; b. an isocyanate-reactive component having at least one compound having the following formula: wherein X, R 1 , R 2 , p, m and n are described in the specification, or isomer or mixture of isomers thereof, two component compositions, articles coated with the novel composition and novel hydroxy amines are also part of the invention.

  一种包括以下成分的涂层组合物：a. 聚异氰酸酯交联剂；b. 具有至少一种化合物的异氰酸酯反应组分，其具有以下公式：其中X、R1、R2、p、m和n在说明书中有描述，或其异构体或异构体混合物，还包括双组分组合物、涂有新型组合物的物品和新型羟胺在内。
• HIGH-PURITY SODIUM P-STYRENESULFONATE WITH EXCELLENT HUE, METHOD FOR PRODUCING THE SAME, POLY (SODIUM P-STYRENESULFONATE) WITH EXCELLENT HUE USING THE SAME, AND DISPERSANT AND SYNTHETIC STARCH FOR CLOTHING FINISHING USING THE POLY ( SODIUM P-STYRENESULFONATE)
  申请人：TOSOH ORGANIC CHEMICAL CO., LTD.

  公开号：US20150246876A1

  公开（公告）日：2015-09-03

  Provided are high purity sodium p-styrenesulfonate with an excellent hue which is useful as a reactive emulsifier or dispersant for producing a polymer emulsion, or synthetic starch for clothing ironing and poly(sodium p-styrene-sulfonate) with an excellent hue using the same or sodium p-styrenesulfonate improved in fluidity while keeping good solubility. An aqueous p-β-bromoethylbenzenesulfonic acid solution and an aqueous sodium hydroxide solution are reacted under specific conditions to control the particle size, thereby obtaining sodium p-styrenesulfonate particles improved in a balance between fluidity and solubility, and further, impurities such as isomers are reduced, thereby obtaining high-purity sodium p-styrenesulfonate with an excellent hue.

  提供高纯度的对苯乙烯磺酸钠，具有优异的色泽，可用作反应性乳化剂或分散剂，用于生产聚合物乳液或合成淀粉用于衣物熨烫以及使用相同或改善流动性但保持良好溶解性的对苯乙烯磺酸钠制备优良色泽的聚(对苯乙烯磺酸钠)。在特定条件下，将水溶性的对β-溴乙基苯磺酸和氢氧化钠水溶液反应，以控制粒子大小，从而获得改善流动性和溶解性平衡的对苯乙烯磺酸钠颗粒，进一步减少异构体等杂质，从而获得具有优异色泽的高纯度对苯乙烯磺酸钠。
• Liquid crystalline compound, liquid crystal composition and their polymers
  申请人：Sasada Yasuyuki

  公开号：US20050007541A1

  公开（公告）日：2005-01-13

  The present invention provides a compound represented by formula (1) defined in the specification and a liquid crystal composition comprising the compound. The invention further provides a polymer obtained by polymerization of compound or composition above, and further the present invention provides a film, an optical anisotropic material, A ¼ or ½ wavelength functional plate, an optical compensation element, an optical element and a liquid crystal display element employing the polymer.

  本发明提供了一种由规范中定义的式（1）所代表的化合物以及包括该化合物的液晶组合物。本发明还提供了通过聚合上述化合物或组合物获得的聚合物，此外，本发明还提供了一种薄膜，一种光学各向异性材料，1/4或1/2波长功能板，光学补偿元件，光学元件和采用该聚合物的液晶显示元件。
• Verification of translation
  申请人：Inagaki Jyun-ichi

  公开号：US20070190344A1

  公开（公告）日：2007-08-16

  A compound represented by Formula (1) and a polymer obtained using the compound: wherein R 1 is phenyl which may have substituents, Q 1 is hydrogen, halogen, alkyl having 1 to 10 carbon atoms, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclohexenyl or phenyl in which optional hydrogen may be replaced by halogen or alkyl having 1 to 5 carbon atoms, Q 2 is a group represented by Formula (2): wherein the code < represents a bonding point with silicon, l, m, n and p are independently 0, 1, 2 or 3, and A 1 to A 4 , Z 0 to Z 4 and Y 1 are defined in the specification.

  公式（1）所表示的化合物和使用该化合物制得的聚合物：其中R1是苯基，可以有取代基；Q1是氢、卤素、具有1至10个碳原子的烷基、环丙基、环丁基、环戊基、环己烯基或苯基，其中可选氢原子可以被卤素或具有1至5个碳原子的烷基所取代；Q2是由公式（2）表示的基团：其中代码<表示与硅的连接点，l、m、n和p独立地为0、1、2或3，A1至A4、Z0至Z4和Y1在规范中有定义。

表征谱图