2-(呋喃-2-基)乙基甲磺酸负离子 | 70745-41-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 中文名称: 2-(呋喃-2-基)乙基甲磺酸负离子
• 英文名称: 2-(Mesyloxy)-1-(2'-furyl)ethane
• 英文别名: Methanesulfonic acid 2-furan-2-yl-ethyl ester；2-(furan-2-yl)ethyl methanesulfonate
• CAS: 70745-41-4
• 化学式: C₇H₁₀O₄S
• 分子量: 190.22
• InChiKey: VACFJSQUJDDRNN-UHFFFAOYSA-N

物化性质

• 沸点：
  337.9±25.0 °C(Predicted)
• 密度：
  1.277±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  64.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(呋喃-2-基)乙基甲磺酸负离子 在 lithium bromide 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 生成 2-Bromo-1-(2'-furyl)ethane
  参考文献：
  名称：

  Jung, Michael E.; Miller, Steven J., Heterocycles, 1990, vol. 30, # 2, p. 839 - 853

  摘要：

  DOI：
• 作为产物：
  描述：

  β-2-呋喃基乙醇 、 甲基磺酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.75h， 以98%的产率得到2-(呋喃-2-基)乙基甲磺酸负离子
  参考文献：
  名称：

  Preparation of enantiopure sultams by intramolecular Diels–Alder reaction of furan-containing vinylsulfonamides

  摘要：

  Enantiomerically pure delta- and gamma-sultams have been prepared by intramolecular [4+2] cycloaddition of N-1-phenylethyl substituted vinylsulforiamides with purely thermal activation and under high pressure, An optimized procedure for reductive debenzylation of the resultant delta-sultams is also reported. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00912-7

文献信息

• Substituted 4a-phenyl-N-phenylalkyl-cis-decahydroisoquinolines
  申请人：E. I. Du Pont de Nemours and Company

  公开号：US04150135A1

  公开（公告）日：1979-04-17

  4A-Aryl-cis-decahydroisoquinolines, such as N-phenethyl-4a-(m-hydroxyphenyl)-cis-decahydroisoquinoline, useful as analgesics.

  4A-芳基-顺式-十氢异喹啉，例如N-苯乙基-4a-(m-羟基苯基)-顺式-十氢异喹啉，可用作镇痛剂。
• Neue cyclische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
  申请人：Dr. Karl Thomae GmbH

  公开号：EP0292840A2

  公开（公告）日：1988-11-30

  Neue cyclische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung. Die vorliegende Erfindung betrifft neue cyclische Aminderivate der allgemeinen Formel in der A, B, E, G, R, R1, R2, m und n wie im Anspruch 1 definiert sind, deren Enantiomeren, deren Diastereomeren, deren N-Oxide und deren Säureadditionssalze, welche wertvolle pharmakologische Eigenschaften aufweisen, inbesondere eine herzfrequenzsenkende Wirkung. Die neuen Verbindungen können nach an sich bekannten Verfahren hergestellt werden.

  新型环胺衍生物、含有这些化合物的药物及其制备工艺。 本发明涉及通式如下的新型环胺衍生物 其中 A、B、E、G、R、R1、R2、m 和 n 如权利要求 1 所定义，它们的对映体、非对映体、N-氧化物和酸加成盐具有重要的药理特性，特别是具有降低心率的作用。 这些新化合物可以用已知的方法生产。
• Nitrogen-containing spirocycles
  申请人：MERCK & CO. INC.

  公开号：EP0431943A2

  公开（公告）日：1991-06-12

  Spirocydes of general structural formula are Class III antiarrhythmic agents. Jouve, 18, rue Saint-Denis, 75001 PARIS

  一般结构式为 是 III 类抗心律失常药物。Jouve, 18, rue Saint-Denis, 75001 PARIS
• Peripherally acting enkephalin analogs. 2. Polar tri- and tetrapeptides
  作者：George W. Hardy、Lawrence A. Lowe、Gail Mills、Pang Yih Sang、Dean S. A. Simpkin、Rhonda L. Follenfant、Clare Shankley、Terence W. Smith

  DOI：10.1021/jm00125a028

  日期：1989.5

  The design, synthesis, and biological activity of a series of D-Arg2-enkephalin-derived tetrapeptide amides and tripeptide aralkylamides are reported. These polar analogues were designed to be excluded from the central nervous system with their action thus limited to peripheral opioid receptors. The effects of the nature of the aromatic ring, aryl ring substitution, and aralkylamine chain length on activity were investigated; in a number of cases the N-terminal amino group of Tyr1 was converted to a guanidino group to further increase hydrophilicity. The peptides were all synthesized by classical solution methodology. The opioid activity of the peptides was assessed in vitro on the guinea pig ileum and their antinociceptive activity was determined in vivo in chemically induced writhing models (peripheral activity) and in the hot-plate test (central activity), in rodents. That the analgesic effects were predominantly mediated in the periphery was demonstrated by antagonism of antinociception by the peripheral opioid antagonist N-methylnalorphine and by comparison of the activities in the writhing and hot-plate tests. As a class, the tetrapeptides were more potent than the tripeptides; N alpha-amidination generally increased activity. A number of compounds exhibited very potent opioid activity and had the desired pharmacological profile, indicating a high degree of peripheral selectivity.
• Preparation of enantiopure sultams by intramolecular Diels–Alder reaction of furan-containing vinylsulfonamides
  作者：Viktor O. Rogatchov、Heiko Bernsmann、Pia Schwab、Roland Fröhlich、Birgit Wibbeling、Peter Metz

  DOI：10.1016/s0040-4039(02)00912-7

  日期：2002.7

  Enantiomerically pure delta- and gamma-sultams have been prepared by intramolecular [4+2] cycloaddition of N-1-phenylethyl substituted vinylsulforiamides with purely thermal activation and under high pressure, An optimized procedure for reductive debenzylation of the resultant delta-sultams is also reported. (C) 2002 Elsevier Science Ltd. All rights reserved.