2-chloro-1-(1-methyl-1H-indol-3-yl)-2-phenylethanone | 69358-98-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-chloro-1-(1-methyl-1H-indol-3-yl)-2-phenylethanone
• 英文别名: 2-chloro-1-(1-methyl-indol-3-yl)-2-phenyl-ethanone；2-chloro-1-(1-methylindol-3-yl)-2-phenylethanone
• CAS: 69358-98-1
• 化学式: C₁₇H₁₄ClNO
• 分子量: 283.757
• InChiKey: GCDRIXWPZUHTPJ-UHFFFAOYSA-N

物化性质

• 沸点：
  453.4±30.0 °C(Predicted)
• 密度：
  1.19±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  22
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-chloro-1-(1-methyl-1H-indol-3-yl)-2-phenylethanone 以48%的产率得到
  参考文献：
  名称：

  NAKAMURA H.; GOTO T., HETEROCYCLES, 1978, 10, SPEC. ISSUE, 167-170

  摘要：

  DOI：
• 作为产物：
  描述：

  吲哚 在 吡啶 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 5.0h， 生成 2-chloro-1-(1-methyl-1H-indol-3-yl)-2-phenylethanone
  参考文献：
  名称：

  [EN] VIRAL REPLICATION INHIBITORS
  [FR] INHIBITEURS DE REPLICATION VIRALE

  摘要：

  本发明涉及一系列新化合物，通过使用这些新化合物来预防或治疗动物的病毒感染的方法，以及将这些新化合物用作药物，更好地用于治疗或预防病毒感染，特别是感染RNA病毒，更特别是感染属于黄病毒科的病毒，更特别是感染登革病毒。本发明还涉及这些新化合物的药物组合或混合制剂，用作药物的组合或制剂，更好地用于预防或治疗病毒感染。该发明还涉及这些化合物的制备方法。

  公开号：

  WO2013045516A1

文献信息

• Metal chelate containing compositions for use in chemiluminescent assays
  申请人：Dade Behring Marburg Inc.

  公开号：US20040121490A1

  公开（公告）日：2004-06-24

  Compositions are disclosed comprising (a) a metal chelate wherein the metal is selected from the group consisting of europium, terbium, dysprosium, samarium osmium and ruthenium in at least a hexacoordinated state and (b) a compound having a double bond substituted with two aryl groups, an oxygen atom and an atom selected from the group consisting of oxygen, sulfur and nitrogen wherein one of the aryl groups is electron donating with respect to the other. Such composition is preferably incorporated in a latex particulate material. Methods and kits are also disclosed for determining an analyte in a medium suspected of containing the analyte. The methods and kits employ as one component a composition as described above.

  本发明揭示了一种组合物，包括(a)一种金属螯合物，其中金属选自欧洲、铽、镝、钐、锇和钌，至少处于六配位状态，以及(b)一种双键上取代有两个芳基基团、一个氧原子和一个选自氧、硫和氮的原子的化合物，其中一个芳基基团相对于另一个芳基基团是电子给予的。此类组合物最好用于乳胶颗粒材料中。还揭示了一种用于确定怀疑含有分析物的介质中的分析物的方法和试剂盒。该方法和试剂盒使用上述组合物作为其中一个组分。
• Cyclic ether compounds
  申请人：Behringwerke AG

  公开号：US05536834A1

  公开（公告）日：1996-07-16

  Compositions are disclosed comprising (a) a metal chelate wherein the metal is selected from the group consisting of europium, terbium, dysprosium, samarium osmium and ruthenium in at least a hexacoordinated state and (b) a compound having a double bond substituted with two aryl groups, an oxygen atom and an atom selected from the group consisting of oxygen, sulfur and nitrogen wherein one of the aryl groups is electron donating with respect to the other. Such composition is preferably incorporated in a latex particulate material. Methods and kits are also disclosed for determining an analyte in a medium suspected of containing the analyte. The methods and kits employ as one component a composition as described above.

  本发明涉及一种组合物，其包括（a）金属配位物，其中金属选自欧洲铕、铽、镝、钐、锇和钌，至少处于六配位状态，并且（b）一种化合物，其具有双键，两个芳基基团，一个氧原子和一个选自氧、硫和氮的原子，其中一个芳基基团对另一个芳基基团具有电子给体作用。该组合物最好用于乳胶颗粒材料中。还公开了一种在怀疑含有分析物的介质中测定分析物的方法和试剂盒。该方法和试剂盒使用上述组合物作为其中一个组分。
• VIRAL REPLICATION INHIBITORS
  申请人：KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D

  公开号：US20140213586A1

  公开（公告）日：2014-07-31

  The present invention relates to a series of novel compounds, methods to prevent or treat viral infections in animals by using the novel compounds and to said novel compounds for use as a medicine, more preferably for use as a medicine to treat or prevent viral infections, particularly infections with RNA viruses, more particularly infections with viruses belonging to the family of the Flaviviridae, and yet more particularly infections with the Dengue virus. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the novel compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of viral infections. The invention also relates to processes for preparation of the compounds.

  本发明涉及一系列新化合物，使用这些新化合物预防或治疗动物的病毒感染的方法，以及这些新化合物的药物用途，更好地用于治疗或预防病毒感染，特别是RNA病毒感染，更特别是属于黄病毒科的病毒感染，更进一步地是登革热病毒感染。本发明还涉及新化合物的药物组成物或复合制剂，以及用于预防或治疗病毒感染的药物组成物或制剂。本发明还涉及化合物的制备方法。
• Viral replication inhibitors
  申请人：KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. Leuven R&D

  公开号：US10550123B2

  公开（公告）日：2020-02-04

  The present invention relates to a series of novel compounds, methods to prevent or treat viral infections in animals by using the novel compounds and to said novel compounds for use as a medicine, more preferably for use as a medicine to treat or prevent viral infections, particularly infections with RNA viruses, more particularly infections with viruses belonging to the family of the Flaviviridae, and yet more particularly infections with the Dengue virus. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the novel compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of viral infections. The invention also relates to processes for preparation of the compounds.

  本发明涉及一系列新型化合物、使用这些新型化合物预防或治疗动物病毒感染的方法以及用作药物的所述新型化合物，更优选用作治疗或预防病毒感染的药物，特别是 RNA 病毒感染，更特别是属于黄病毒科的病毒感染，更特别是登革热病毒感染。本发明还涉及新型化合物的药物组合物或组合制剂、用作药物的组合物或制剂，更优选用于预防或治疗病毒感染。本发明还涉及化合物的制备工艺。
• Nakamura,H.; Goto,T., Heterocycles, 1978, vol. 10, p. 167 - 170
  作者：Nakamura,H.、Goto,T.

  DOI：——

  日期：——