5-(2,4-dichlorophenyl)-3-(pyridin-2-yl)-1,2,4-oxadiazole | 339103-05-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(2,4-dichlorophenyl)-3-(pyridin-2-yl)-1,2,4-oxadiazole
• 英文别名: 2-[5-(2,4-Dichlorophenyl)-1,2,4-oxadiazol-3-yl]pyridine；5-(2,4-dichlorophenyl)-3-pyridin-2-yl-1,2,4-oxadiazole
• CAS: 339103-05-8
• 化学式: C₁₃H₇Cl₂N₃O
• 分子量: 292.124
• InChiKey: WBMHQMQALJDGHI-UHFFFAOYSA-N

物化性质

• 沸点：
  457.4±55.0 °C(Predicted)
• 密度：
  1.415±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,4-二氯苯甲酸 在 草酰氯 、 N,N-二甲基甲酰胺 作用下， 以 二氯甲烷 为溶剂， 生成 5-(2,4-dichlorophenyl)-3-(pyridin-2-yl)-1,2,4-oxadiazole
  参考文献：
  名称：

  Discovery and characterization of AZD9272 and AZD6538—Two novel mGluR5 negative allosteric modulators selected for clinical development

  摘要：

  AZD9272 and AZD6538 are two novel mGluR5 negative allosteric modulators selected for further clinical development. An initial high-throughput screening revealed leads with promising profiles, which were further optimized by minor, yet indispensable, structural modifications to bring forth these drug candidates. Advantageously, both compounds may be synthesized in as little as one step. Both are highly potent and selective for the human as well as the rat mGluR5 where they interact at the same binding site than MPEP. They are orally available, allow for long interval administration due to a high metabolic stability and long half-lives in rats and permeate the blood brain barrier to a high extent. AZD9272 has progressed into phase I clinical studies. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.08.100

文献信息

• 방향제 용기 교체수납이 용이하고 균일한 방향효과를 나타내도록 한 차량용 방향봉제인형
  申请人：Byun dong soo 변동수(420000077949)

  公开号：KR20210000460U

  公开（公告）日：2021-03-02

  본 고안은 방향제 용기 교체수납이 용이고 균일한 방향효과를 나타내도록 한 차량용 방향봉제인형에 관한 것으로, 보다 상세하게는, 차량 내부에 거치형, 걸이형 또는 클립형으로 부착하여 장식용으로 사용되는 봉제인형 내부에 방향제 용기 수납 공간을 형성하여 봉제인형을 통한 균일한 방향효과를 나타내도록 하면서 방향제 용기 교체수납이 용이하도록 한 차량용 방향봉제인형에 관한 것이다.

  这项发明涉及一种车辆用方向棒模型，其方向剂容器更换存放方便且具有均匀的方向效果，更详细地说，通过在车辆内部安装支架式、挂钩式或夹子式的装饰用棒模型内部形成方向剂容器存放空间，从而实现通过棒模型展示均匀的方向效果，并使方向剂容器更换存放更加方便的车辆用方向棒模型。