1-(2-Chloro-4-pyrrolidin-1-ylphenyl)ethanone | 1342374-42-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2-Chloro-4-pyrrolidin-1-ylphenyl)ethanone
• CAS: 1342374-42-8
• 化学式: C₁₂H₁₄ClNO
• 分子量: 223.702
• InChiKey: LOOIVIWWMINKMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  四氢吡咯 、 2,4-二氯苯乙酮 在 magnesium hydroxide nanoparticles 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 24.0h， 以22%的产率得到1-(2-Chloro-4-pyrrolidin-1-ylphenyl)ethanone
  参考文献：
  名称：

  Amination of electron deficient aryl chlorides promoted by nano sized Mg(OH)2 under transition metals free condition

  摘要：

  This paper presents the amination reactions of electron deficient aryl chlorides promoted by Mg(OH)(2) without transition metals. Only using stoichiometric amount of nano sized Mg(OH)(2), good to moderate isolated yields could be achieved in N-methylpyrrolidone (NMP) after 24 h at 150 degrees C. (C) 2011 Published by Elsevier B.V. on behalf of Chinese Chemical Society.

  DOI：

  10.1016/j.cclet.2011.11.009

文献信息

• Amination of electron deficient aryl chlorides promoted by nano sized Mg(OH)2 under transition metals free condition
  作者：Zhi Hao Cui、Zi Hui Meng、Yan Qing Mi、Peng Wang、Qi Wang、Lin Man Zhao、Ke Jian Cui、Fang Yu、Zhi Bin Xu

  DOI：10.1016/j.cclet.2011.11.009

  日期：2012.2

  This paper presents the amination reactions of electron deficient aryl chlorides promoted by Mg(OH)(2) without transition metals. Only using stoichiometric amount of nano sized Mg(OH)(2), good to moderate isolated yields could be achieved in N-methylpyrrolidone (NMP) after 24 h at 150 degrees C. (C) 2011 Published by Elsevier B.V. on behalf of Chinese Chemical Society.