2,4-dimethyl-2-pentyl acetate | 34856-44-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2,4-dimethyl-2-pentyl acetate
• 英文别名: 2-Acetoxy-2,4-dimethylpentan；1,1,3-Trimethylbutylacetat；2,4-Dimethylpentan-2-yl acetate
• CAS: 34856-44-5
• 化学式: C₉H₁₈O₂
• 分子量: 158.241
• InChiKey: LADFKKFOLNKFLW-UHFFFAOYSA-N

物化性质

• 沸点：
  153.5±8.0 °C(Predicted)
• 密度：
  0.874±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,4-dimethyl-2-pentyl acetate 生成 2,4-二甲基-1-戊烯 、 2,4-二甲基-2-戊烯
  参考文献：
  名称：

  叔乙酸酯醇侧的烷基和极性取代基与气相中热解速率的相关性

  摘要：

  DOI：

  10.1021/j100253a052
• 作为产物：
  描述：

  1,1,2,2-四甲基环丙烷 、 溶剂黄146 在 对甲苯磺酸 作用下， 以63%的产率得到2,3,3-三乙基-1-丁烯
  参考文献：
  名称：

  Electrophilic cleavage of cyclopropanes. Acetolysis of alkylcyclopropanes

  摘要：

  DOI：

  10.1021/ja00290a040

文献信息

• HETEROCYCLIC CETP INHIBITORS
  申请人：Salvati E. Mark

  公开号：US20070161685A1

  公开（公告）日：2007-07-12

  Compounds of formula Ia and Ib wherein A, B, C and R 1 are described herein.

  式Ia和Ib的化合物 其中A、B、C和R1 如本文所述。
• Phenanthrene derivatives as MPGES-1 inhibitors
  申请人：Cote Bernard

  公开号：US20090209571A1

  公开（公告）日：2009-08-20

  The invention encompasses novel compounds of Formula or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.

  本发明涵盖了公式或其药学上可接受的盐的新型化合物。这些化合物是微粒体前列腺素E合成酶-1(mPGES-1)酶的抑制剂，因此可用于治疗各种疾病或病况引起的疼痛和/或炎症，例如骨关节炎、类风湿性关节炎和急性或慢性疼痛。本发明还涵盖了治疗由mPGES-1酶介导的疾病或病况的方法和制药组合物。
• NOVEL ION EXCHANGE POROUS RESINS FOR SOLID PHASE EXTRACTION AND CHROMATOGRAPHY
  申请人：LEE Peter Jeng Jong

  公开号：US20100324159A1

  公开（公告）日：2010-12-23

  Embodiments of the present invention are directed to porous resins for solid phase extractions. The resins feature at least one hydrophobic component, at least one hydrophilic component and at least one ion exchange functional group. The resins exhibit superior wetting and ion exchange performance.
• SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS
  申请人：Array BioPharma, Inc.

  公开号：US20180133200A1

  公开（公告）日：2018-05-17

  Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X 1 , X 2 , X 3 , X 4 , Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.
• US7888376B2
  申请人：——

  公开号：US7888376B2

  公开（公告）日：2011-02-15