4-O-n-octylbutan-1-ol | 71780-61-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-O-n-octylbutan-1-ol
• 英文别名: 4-octyloxy-butan-1-ol；1-Butanol, 4-(octyloxy)-；4-octoxybutan-1-ol
• CAS: 71780-61-5
• 化学式: C₁₂H₂₆O₂
• 分子量: 202.337
• InChiKey: PHIVDNISJOSJNM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  14
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-O-n-octylbutan-1-ol 在 4-二甲氨基吡啶 、 水 、 三氟乙酸 、 potassium hydroxide 作用下， 以 乙醚 、 二氯甲烷 、 二甲基亚砜 、 甲苯 为溶剂， 反应 24.0h， 生成 6-O-(4-O-n-octylbut-1-yl)-α-D-galactopyranose
  参考文献：
  名称：

  Synthesis, surface tension properties and antibacterial activities of amphiphilic d -galactopyranose derivatives

  摘要：

  Several amphiphilic D-galactopyranose derivatives were synthesized in which the glycosidic moiety was separated from the hydrophobic alkyl chain (along 8 or 12 carbon atoms) by a spacer arm (butyl, butynyl or benzyl) in order to increase their surfactant properties and to obtain new antibacterial compounds. The surface tensions of the products were analyzed by Critical Micelle Concentration (CMC) and gamma(CMC) measurements and the antimicrobial activities were assayed against 10 bacterial species by Minimum Inhibitory Concentration (MIC) determination in liquid broth. The introduction of an aliphatic spacer arm increased the amphiphilic properties of the compounds and the CMC values were 40-500 times lower than their analogs without spacer arm. In the same manner, the spacer arms significantly increased the antibacterial power of the compounds. The products 4d and 4e exhibiting a C12 alkyl chain and an aliphatic spacer arm (butyl and butynyl) were the best surfactants (CMC = 0.023 and 0.032 mmol/L, respectively) and presented also the best antibacterial activities (MIC = 15.62 and 3.91 mu g/mL for Micrococcus luteus, respectively). But the antibacterial activity of the newly synthesized products seemed to depend more on the cell wall composition of the bacteria than only on the amphiphilic character of the compounds. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.12.032
• 作为产物：
  描述：

  2-(octyloxy)-tetrahydrofuran 在 lithium aluminium tetrahydride 、 三氯化铝 作用下， 生成 4-O-n-octylbutan-1-ol
  参考文献：
  名称：

  Kruse,C.G. et al., Recueil des Travaux Chimiques des Pays-Bas, 1979, vol. 98, p. 371 - 380

  摘要：

  DOI：

文献信息

• Antistatic agent and resin composition and formed product
  申请人：——

  公开号：US20040132879A1

  公开（公告）日：2004-07-08

  An antistatic agent characterized by containing a borate ester of polyoxyalkylene and an antistatic resin composition comprizing a thermoplastic resin and the borate ester of polyoxyalkylene and antistatic plastic resin formed product made by the plastic resin composition described above.

  一种抗静电剂，其特征在于含有聚氧亚烷基硼酸酯和由热塑性树脂和聚氧亚烷基硼酸酯组成的抗静电树脂组合物，以及由上述塑料树脂组合物制成的抗静电塑料树脂成型品。
• Synthesis and antiproliferative activity of alkylphosphocholines
  作者：Mandy Agresta、Paola D’Arrigo、Ezio Fasoli、Daniele Losi、Giuseppe Pedrocchi-Fantoni、Simona Riva、Stefano Servi、Davide Tessaro

  DOI：10.1016/j.chemphyslip.2003.08.002

  日期：2003.12

  Alkylphosphocholines (APC) with one or more methylene groups in the alkyl chain replaced by oxygen atoms or carbonyl groups, or both have been assembled modularly using w-diols as central building blocks. Out of 25 new compounds of this kind, I I were evaluated for their antiproliferative activity on four cell lines and compared with miltefosine to evaluate their hemolytic activity (HA); and cytotoxicity on non-tumoral cells (MT2), used as markers of adverse effects. Compound 13 was more active on cancer cell lines than on non-tumoral cells and the data were similar for MTT and thymidine incorporation assays. It had less HA than miltefosine, Compound 13 could therefore be a candidate for the preparation of compounds with higher cytotoxicity on cancer cells and lower general toxicity. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
• KRUSE C. G.; DERT V.; JONKERS F. L.; GEN A. VAN DER, REC. TRAV. CHIM. PAYS-BAS, 1979, 98, NO 6, 371-380
  作者：KRUSE C. G.、 DERT V.、 JONKERS F. L.、 GEN A. VAN DER

  DOI：——

  日期：——
• Release agent for metallic mold
  申请人：——

  公开号：US20040083925A1

  公开（公告）日：2004-05-06

  A release agent for metallic mold for forming a plastic molded product characterized by containing a borate ester of polyoxyalkylene.
• Resin composition for purging contaminant in the plastic processing machine
  申请人：——

  公开号：US20040132878A1

  公开（公告）日：2004-07-08

  Disclosed is a resin composition for purging away contaminant in the plastic processing machine and a purging method of a contaminant in the plastic processing machine using the resin composition. The resin composition comprizes a thermoplastic resin and borate ester of polyoxyalkylene.