ditropylether | 16273-47-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ditropylether
• 英文别名: di-7-cycloheptatrienyl ether；di-cyclohepta-2,4,6-trienyl ether；Di-cyclohepta-2,4,6-trienyl-aether；Bis--ether；Di--ether；Ditropylaether；7-Cyclohepta-2,4,6-trien-1-yloxycyclohepta-1,3,5-triene
• CAS: 16273-47-5
• 化学式: C₁₄H₁₄O
• 分子量: 198.265
• InChiKey: KNFQDAOJJNEQEQ-UHFFFAOYSA-N

物化性质

• 沸点：
  341.0±11.0 °C(Predicted)
• 密度：
  1.04±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  ditropylether 在 三氟乙酸 作用下， 以 氘代氯仿 为溶剂， 反应 3.0h， 生成 环庚三烯酮 、 环庚三烯
  参考文献：
  名称：

  NMR光谱法明确检测2,4,6-环庚三烯-1-醇并用苯基三唑啉二酮捕获

  摘要：

  首次通过NMR光谱法明确地检测出标题醇3作为过渡中间体，导致水溶液中对yl离子（5）与氢氧根离子之间的阳离子-阴离子反应中的二tropylether（6）。人们还发现，6给出3中的酸催化歧化瞬态产物6成环庚三烯酮的混合物（4）和1,3,5-环庚三烯（7在含有水氯仿）。再者3的存在在后者的反应通过用4-苯基-1,2,4-三唑啉-3,5-二酮捕集得到的norcaradiene形式的[4 + 2]环加成确认3。

  DOI：

  10.1016/s0040-4020(02)01617-4
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydroxide 作用下， 生成 ditropylether
  参考文献：
  名称：

  Bryce-Smith; Perkins, Chemistry and industry, 1959, p. 1022

  摘要：

  DOI：

文献信息

• ter Borg,A.P. et al., Recueil des Travaux Chimiques des Pays-Bas, 1962, vol. 81, p. 177 - 184
  作者：ter Borg,A.P. et al.

  DOI：——

  日期：——
• Long-term treatment of focal segmental glomerulosclerosis in children with cyclosporine given as a single daily dose
  作者：Aftab S. Chishti、Jonathan M. Sorof、Eileen D. Brewer、Arundhati S. Kale

  DOI：10.1053/ajkd.2001.27692

  日期：2001.10

  Cyclosporine (CsA) has been successfully used for treatment of children with focal segmental glomerulosclerosis (FSGS) and nephrotic syndrome (NS) for the last decade. Response rates of 50% to 100% have been reported using twice-daily dosing of 5 to 32 mg/kg/d, achieving trough blood levels of 70 to 500 ng/mL. Treatment has been associated with a high incidence of side effects, including nephrotoxicity, hypertension, gingival hyperplasia, and hirsutism. To determine whether once-daily low-dose CsA could minimize side effects and still induce remission, 21 children with biopsy-proven FSGS and NS, each treated with CsA, 4.6 +/- 0.8 mg/kg/d, with no predetermined target trough blood levels, were studied. Eleven of 21 children (52%) attained complete remission and 5 of 21 children (24%) attained partial remission, for a total response rate of 76%. Mean time to response was 2.8 +/- 0.8 months, and mean duration of therapy was 20.6 +/- 13.7 months. CsA dosage was tapered or stopped in 9 responders; 3 of these patients maintained remission at last follow-up 6 to 13 months later, and 6 patients relapsed at 1.5 to 18.7 months (mean, 8.7 months). Five of these 6 patients responded again when CsA therapy was restarted or the dosage was increased. Twelve of 16 responders were still being administered CsA at last follow-up 11 to 60 months (mean, 24.6 months) later. Five of 21 patients (24%) had no response to CsA during 2 to 27 months of therapy; 4 of these 5 patients developed end-stage renal disease after CsA therapy was stopped. Side effects of CsA therapy were minimal: 1 patient each developed new-onset hypertension or gingival hyperplasia, and no patient had hirsutism or nephrotoxicity. Single daily low-dose CsA appears to be effective for long-term treatment of children with FSGS and NS, with fewer side effects than twice-daily dosing. (C) 2001 by the National Kidney Foundation, Inc.
• terBorg; Kloosterziel, Recueil des Travaux Chimiques des Pays-Bas, 1963, vol. 82, p. 741,754
  作者：terBorg、Kloosterziel

  DOI：——

  日期：——
• Vol'pin,M.E. et al., Journal of general chemistry of the USSR, 1960, vol. 30, p. 170 - 173
  作者：Vol'pin,M.E. et al.

  DOI：——

  日期：——
• Orlando; Weiss, Journal of Organic Chemistry, 1962, vol. 27, p. 4714 Anm. 6
  作者：Orlando、Weiss

  DOI：——

  日期：——