2-(环己基甲基)吡唑-3-胺 | 3524-26-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 2-(环己基甲基)吡唑-3-胺
• 中文别名: 1-(环己基甲基)-1H-吡唑-5-胺；[2-(环己基甲基)吡唑-3-基]胺
• 英文名称: 1-(cyclohexylmethyl)-1H-pyrazol-5-amine
• 英文别名: 2-(cyclohexylmethyl)pyrazol-3-amine
• CAS: 3524-26-3
• 化学式: C₁₀H₁₇N₃
• mdl: MFCD06655724
• 分子量: 179.26
• InChiKey: HQBNRQCHZMQTON-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2933199090

文献信息

• [EN] TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS<br/>[FR] COMPOSÉS TÉTRAZOLIQUES COMME ANTAGONISTES DES RÉCEPTEURS À L'OREXINE
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2009150614A1

  公开（公告）日：2009-12-17

  The invention relates to tetrazole compounds of formula (I) wherein X, Y, Z, R1, R2 and R3 are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.

  该发明涉及式(I)的四唑化合物，其中X、Y、Z、R1、R2和R3如描述中所述；其药学上可接受的盐，以及将这些化合物用作药物，特别是促进睡眠药物的药物受体拮抗剂。
• TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS
  申请人：Aissaoui Hamed

  公开号：US20110086889A1

  公开（公告）日：2011-04-14

  The invention relates to tetrazole compounds of formula (I) wherein X, Y, Z, R 1 , R 2 and R 3 are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.

  该发明涉及式（I）的四唑化合物，其中X、Y、Z、R1、R2和R3如描述中所述；其药学上可接受的盐，以及将这些化合物用作药物，特别是促进睡眠的药物。
• Hsp90 inhibitors and uses thereof
  申请人：TRUSTEES OF BOSTON UNIVERSITY

  公开号：US11312722B2

  公开（公告）日：2022-04-26

  Herein is described the design and synthesis of resorcylate aminopyrazole compounds. These compounds show broad, potent and fungal-selective Hsp90 inhibitory activity. These compounds also find use in treating Hsp90 related diseases.

  本文介绍了对羟基氨基吡唑化合物的设计和合成。这些化合物具有广泛、强效和真菌选择性的 Hsp90 抑制活性。这些化合物还可用于治疗与 Hsp90 相关的疾病。
• HSP90 INHIBITORS AND USES THEREOF
  申请人：TRUSTEES OF BOSTON UNIVERSITY

  公开号：US20200354373A1

  公开（公告）日：2020-11-12

  Herein is described the design and synthesis of resorcylate aminopyrazole compounds. These compounds show broad, potent and fungal-selective Hsp90 inhibitory activity. These compounds also find use in treating Hsp90 related diseases.