2-((3-(dicyanomethyl)-5-methyl-2-oxoindolin-3-yl)thio)acetic acid | 1451707-54-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-((3-(dicyanomethyl)-5-methyl-2-oxoindolin-3-yl)thio)acetic acid
• 英文别名: 2-[3-(dicyanomethyl)-5-methyl-2-oxoindolin-3-ylthio]acetic acid；2-[3-(Dicyanomethyl)-5-methyl-2-oxoindolin-3-ylthio]acetic acid；2-[[3-(dicyanomethyl)-5-methyl-2-oxo-1H-indol-3-yl]sulfanyl]acetic acid
• CAS: 1451707-54-2
• 化学式: C₁₄H₁₁N₃O₃S
• 分子量: 301.326
• InChiKey: GKYPRTKLGGJYDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  139
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  5-methyl-3-dicyanomethylene-2H-indole-2-one 、 巯基乙酸 在 copper(II) ferrite 作用下， 以 水 为溶剂， 反应 3.0h， 以76%的产率得到2-((3-(dicyanomethyl)-5-methyl-2-oxoindolin-3-yl)thio)acetic acid
  参考文献：
  名称：

  Cufe₂O₄ Nanoparticles: A Magnetically Retrievable Catalyst for Green Synthesis of Novel 2-(3-(Dicyanomethyl)-2-Oxoindolin-3-Ylthio)Acetic Acids

  摘要：

  A highly efficient and green method for the synthesis of new 2-(3-(dicyanomethyl)-2-oxoindolin-3-ylthio)acetic acids is described using magnetically recoverable and reusable CuFe2O4 nanoparticles. A wide variety of aryl isatylidene malononitrils underwent Micheal addition with thioacids to afford novel 2-(3-(dicyanomethyl)-2-oxoindolin-3-ylthio)acetic acids in good to excellent yields. The reaction protocol is operationally simple and mild. Moreover, water as solvent makes the reaction procedure eco-friendly and economically viable. All products were characterized by NMR and IR spectroscopies.

  DOI：

  10.1080/10426507.2013.788004

文献信息

• Recyclable bimetallic CuFe2O4 nanoparticles: an efficient catalyst for one-pot three-component synthesis of novel dicyanomethyl-2-oxoindolin-3-ylthiocarboxylic acids in a green solvent
  作者：Ghazaleh Imani Shakibaei、Ramin Ghahremanzadeh、Ayoob Bazgir

  DOI：10.1007/s00706-014-1159-z

  日期：2014.6

  AbstractA highly efficient and green synthesis of novel, potentially medicinally important oxindole derivatives has been developed using a fully recoverable heterogeneous copper ferrite nanocatalyst in water as a green solvent. The catalyst is magnetically separable and recyclable up to the fourth run without significant loss of activity. The products were obtained in high yields and purities via an

  摘要使用在水中作为绿色溶剂的完全可回收的多相铜铁氧体纳米催化剂，已经开发出高效，绿色的新型，可能具有医学上重要意义的羟吲哚衍生物。该催化剂可磁分离并循环使用至第四次，而活性没有明显损失。通过简单的后处理程序以高产率和高纯度获得了产物。 图形概要
• Cufe₂O₄ Nanoparticles: A Magnetically Retrievable Catalyst for Green Synthesis of Novel 2-(3-(Dicyanomethyl)-2-Oxoindolin-3-Ylthio)Acetic Acids
  作者：Ghazaleh Imani Shakibaei、Ramin Ghahremanzadeh、Ayoob Bazgir

  DOI：10.1080/10426507.2013.788004

  日期：2013.10.1

  A highly efficient and green method for the synthesis of new 2-(3-(dicyanomethyl)-2-oxoindolin-3-ylthio)acetic acids is described using magnetically recoverable and reusable CuFe2O4 nanoparticles. A wide variety of aryl isatylidene malononitrils underwent Micheal addition with thioacids to afford novel 2-(3-(dicyanomethyl)-2-oxoindolin-3-ylthio)acetic acids in good to excellent yields. The reaction protocol is operationally simple and mild. Moreover, water as solvent makes the reaction procedure eco-friendly and economically viable. All products were characterized by NMR and IR spectroscopies.