bis-isopropoxymethyl ether | 38672-22-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: bis-isopropoxymethyl ether
• 英文别名: α.α'-Diisopropyloxy-dimethylaether；Bis-isopropoxymethyl-aether；Bis-(iso-propoxymethyl)-ether；Diisopropyloxy-dimethylether；Mono(isopropoxymethyl) ether；2-(propan-2-yloxymethoxymethoxy)propane
• CAS: 38672-22-9
• 化学式: C₈H₁₈O₃
• 分子量: 162.229
• InChiKey: KSDLQBHSZNTNCO-UHFFFAOYSA-N

物化性质

• 沸点：
  30-32 °C(Press: 15 Torr)
• 密度：
  0.876 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  溴(溴甲氧基)甲烷 、 异丙醇 在 sodium hydroxide 作用下， 生成 bis-isopropoxymethyl ether
  参考文献：
  名称：

  The nature of the new employment relationship: A content analysis of the practitioner and academic literatures

  摘要：

  At a general level, there appears to be almost universal agreement that the nature of the employment relationship is undergoing fundamental changes that have potentially enormous implications for how companies attract, motivate, and retain talent. This article is intended to assist HRM professionals in understanding, evaluating, and responding to those changes. The results of a study that evaluates current thinking regarding the nature of the new employment relationship by systematically analyzing the content of relevant articles are reported. Implications of the results for the management of employee relationships are discussed, and specific recommendations are provided. (C) 2000 John Wiley and Sons, Inc.

  DOI：

  10.1002/1099-050x(200024)39:4<305::aid-hrm3>3.0.co;2-v

文献信息

• Cyclosporins and their use as pharmaceuticals
  申请人：SANDOZ AG

  公开号：EP0296122A2

  公开（公告）日：1988-12-21

  Cyclosporins wherein the residue at the 1-position (typically -MeBmt- or -dihydro-MeBmt-) is 3′O-acylated or 3′-oxo or -C₁₋₄alkoxyimino substituted, or wherein the residue at the 2-position is β-O-acyl or β-oxo substituted, or wherein the residue at the 2-position is -Ile-, or wherein the residue at the 11-position is -MeAla-, -MeIle- or -MealloIle- as well as various naturally occurring cyclosporins/dihydro-derivatives thereof, are useful in reversing resistance to chemotherapy, in particular resistance to cytostatic or anti-neoplastic therapy. Various of these cyclosporins and intermediates for their production are novel. Intermediates wherein the residue (e.g. -MeBmt-, -dihydro-MeBmt- etc.) at the 1-position is 8′-alkoxy of 7′-desmethyl-7′-hydrocarbyl substituted are novel and useful as immunosuppressants, anti-inflammatory and anti-parasitic agents.

  1-位残基（通常为-MeBmt-或-dihydro-MeBmt-）为3′O-酰基或3′-氧代或-C₁₋₄烷氧基亚氨基取代的环孢菌素，或2-位残基为β-O-酰基或β-氧代的环孢菌素，或2-位残基为-Ile-的环孢菌素、或其中 11 位上的残基为-MeAla-、-MeIle-或-MealloIle-，以及各种天然存在的环孢素/其二氢衍生物，可用于逆转对化疗的耐药性，特别是对细胞抑制剂或抗肿瘤疗法的耐药性。这些环孢素和生产它们的中间体都是新型的。其中1位残基（如-MeBmt-、-二氢-MeBmt-等）为7′-去甲基-7′-氢羰基取代的8′-烷氧基的中间体是新型的，可用作免疫抑制剂、消炎药和抗寄生虫药。
• INK FOR USE IN A COLOR FILTER, COLOR FILTER, METHOD OF MANUFACTURING A COLOR FILTER, IMAGE DISPLAY APPARATUS, ELECTRONIC APPARATUS
  申请人：TAKIGUCHI Hiroshi

  公开号：US20090015765A1

  公开（公告）日：2009-01-15

  An ink for use in manufacturing a color filter by an ink-jet together with other inks, the ink having a predetermined color which is different from colors of the other inks. The ink comprises a coloring agent which has a color corresponding to the predetermined color of the ink, and a liquid medium in which the coloring agent is dissolved and/or dispersed, the liquid medium comprised of a component A and a component B, wherein a boiling point of the component B is higher than a boiling point of the component A, and a viscosity of the component B at a temperature of 25° C. is higher than a viscosity of the component A at a temperature of 25° C. The ink can be used for manufacturing the color filter which has no uneven color or no uneven density. Further, the ink can also be used for manufacturing the color filter which has excellent uniformity of characteristics among the manufactured color filters. A color filter which has no uneven color or no uneven density and has excellent uniformity of characteristics among the manufactured color filters is also provided. A method of manufacturing such a color filter is also provided. An image display apparatus that can suitably use such a color filter is also provided. An electronic apparatus that can suitably use such an image display apparatus is also provided.
• COMBINATION PRODUCT FOR THE INDUCTION AND/OR MAINTENANCE OF GENERAL ANESTHESIA
  申请人：BLUMENTECH, S.L.

  公开号：US20210186927A1

  公开（公告）日：2021-06-24

  The state of general anesthesia (GA) is essential to many surgical and medical procedures. This state is characterized by loss of consciousness, deep analgesia and suppression of movements. GA is rarely achieved with a single drug, usually requiring the combination of various pharmacological agents. Each drug can interact with one or more molecular targets affecting neuronal excitability and synaptic transmission in multiple regions of the CNS. Agonists of the μ-opioid receptor are commonly used in GA to cause analgesia, but not to induce or maintain loss of consciousness or movement suppression. Additionally, agonists of the μ-opioid receptor can cause serious unwanted side effects, e.g. respiratory depression. The present invention provides alternative combination products based on K-opioid receptor agonists. These combination products unexpectedly induced loss of consciousness, and were able to achieve and maintain GA. Furthermore, the combination products suppressed pain perception without the need of a μ-opioid receptor agonist. The combination of Salvinorin A, a selective κ-opioid receptor agonist, with Diazepam or Medetomidine surprisingly led to rapid consciousness, deep analgesia and movement suppression. This combination was found to effectively induce and maintain a state of general anesthesia.
• The nature of the new employment relationship: A content analysis of the practitioner and academic literatures
  作者：Mark V. Roehling、Marcie A. Cavanaugh、Lisa M. Moynihan、Wendy R. Boswell

  DOI：10.1002/1099-050x(200024)39:4<305::aid-hrm3>3.0.co;2-v

  日期：——

  At a general level, there appears to be almost universal agreement that the nature of the employment relationship is undergoing fundamental changes that have potentially enormous implications for how companies attract, motivate, and retain talent. This article is intended to assist HRM professionals in understanding, evaluating, and responding to those changes. The results of a study that evaluates current thinking regarding the nature of the new employment relationship by systematically analyzing the content of relevant articles are reported. Implications of the results for the management of employee relationships are discussed, and specific recommendations are provided. (C) 2000 John Wiley and Sons, Inc.