cytidylyl-(3'->5')-cytidylyl-(3'->5')-adenosine | 2866-39-9

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 核苷和核苷酸类似物
• 英文名称: cytidylyl-(3'->5')-cytidylyl-(3'->5')-adenosine
• 英文别名: Cytidylyl-(3'-5')-cytidylyl-(3'-5')-adenosine；[(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-2-[[[(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxy-hydroxyphosphoryl]oxymethyl]-4-hydroxyoxolan-3-yl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate
• CAS: 2866-39-9
• 化学式: C₂₈H₃₇N₁₁O₁₈P₂
• 分子量: 877.612
• InChiKey: SYSZGJKBOHEMPB-FIVCZYLNSA-N

物化性质

• 沸点：
  1240.8±75.0 °C(Predicted)
• 密度：
  2.28±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -9
• 重原子数：
  59
• 可旋转键数：
  14
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  427
• 氢给体数：
  10
• 氢受体数：
  22

反应信息

• 作为反应物：
  描述：

  cytidylyl-(3'->5')-cytidylyl-(3'->5')-adenosine 、 靛红酸酐 在 sodium hydroxide 作用下， 以 水 、 乙腈 为溶剂， 反应 3.0h， 生成 邻氨基苯甲酸 、 、
  参考文献：
  名称：

  Aminoacyl-tRNA Analogues; Synthesis, Purification and Properties of 3^′-Anthraniloyl Oligoribonucleotides

  摘要：

  Reaction of isatoic anhydride with adenosine, adenosine 5'-phosphate, oligoribonucleotides or with the E. coli tRNA(Val) led to attachment of an anthraniloyl residue at 2'- or 3'-OH groups of 3'-terminal ribose residue. No protection of the 5'-hydroxyl group or internal 2'-hydroxyl groups is required for this specific reaction. Anthraniloyl-tRNA which is an analogue of aminoacyl-tRNA forms a ternary complex with EF-Tu*GTP. The anthraniloyl-residue is used as a fluorescent reporter group to monitor interactions with proteins.

  DOI：

  10.1080/07328319808004677
• 作为产物：
  描述：

  在 盐酸 、 氨 、 zinc(II) chloride 作用下， 生成 cytidylyl-(3'->5')-cytidylyl-(3'->5')-adenosine
  参考文献：
  名称：

  A convenient method for insertion of the 5'-terminal phosphate group in the triester approach to oligoribonucleotide synthesis

  摘要：

  DOI：

  10.1021/jo01304a042

文献信息

• Aminoacyl derivatives of nucleosides, nucleotides and polynucleotides. 43. New approach to synthesis of 2'(3')-O-aminoacyl oligoribonucleotides
  作者：Erwin Happ、Claudia Scalfi-Happ、Stanislav Chladek

  DOI：10.1021/jo00233a015

  日期：1987.11
• Aminoacyl-tRNA Analogues; Synthesis, Purification and Properties of 3^′-Anthraniloyl Oligoribonucleotides
  作者：B. Nawrot、M. Sprinzl

  DOI：10.1080/07328319808004677

  日期：1998.4

  Reaction of isatoic anhydride with adenosine, adenosine 5'-phosphate, oligoribonucleotides or with the E. coli tRNA(Val) led to attachment of an anthraniloyl residue at 2'- or 3'-OH groups of 3'-terminal ribose residue. No protection of the 5'-hydroxyl group or internal 2'-hydroxyl groups is required for this specific reaction. Anthraniloyl-tRNA which is an analogue of aminoacyl-tRNA forms a ternary complex with EF-Tu*GTP. The anthraniloyl-residue is used as a fluorescent reporter group to monitor interactions with proteins.
• A convenient method for insertion of the 5'-terminal phosphate group in the triester approach to oligoribonucleotide synthesis
  作者：Hiroshi Takaku、Masaatsu Kato、Masatoshi Yoshida、Ryuichi Yamaguchi

  DOI：10.1021/jo01304a042

  日期：1980.8