阿巴卡韦杂质 | 783292-37-5

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 核苷和核苷酸类似物
• 中文名称: 阿巴卡韦杂质
• 英文名称: Abacavir, trans-
• 英文别名: [(1R,4R)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-en-1-yl]methanol
• CAS: 783292-37-5；1443421-67-7
• 化学式: C₁₄H₁₈N₆O
• 分子量: 286.33
• InChiKey: MCGSCOLBFJQGHM-WPRPVWTQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  102
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Process for the Preparation of Abacavir
  申请人：Medrano Rupérez Jorge

  公开号：US20100004446A1

  公开（公告）日：2010-01-07

  Process for removal of the amino protective group of a N-acylated [(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-cyclopent-2-enyl]methanol of formula (II) where R═H or a (C 1 -C 4 )-alkyl, using an inorganic base in a mixture of water and alcohol, to yield abacavir or its salts. The process proceeds very fast and the product can be obtained in high yield and purity.

  去除N-酰化的[(1S,4R)-4-[2-氨基-6-(环丙基氨基)-9H-嘌呤-9-基]-环戊-2-烯基]甲醇的氨基保护基团的过程，其中R = H或(C1-C4)-烷基，使用无机碱在水和醇的混合物中，得到阿巴卡韦或其盐。该过程进行得非常快速，产物可高产率和高纯度获得。
• SYNERGISTIC COMBINATIONS OF ZIDOVUDINE, 1592U89 AND 3TC
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0817637B1

  公开（公告）日：2002-07-17
• COMPOSITIONS AND METHODS FOR REACTIVATING LATENT IMMUNODEFICIENCY VIRUS
  申请人：Icahn School of Medicine Mount Sinai

  公开号：EP2830629A1

  公开（公告）日：2015-02-04
• [EN] COMPOSITIONS AND METHODS FOR MODULATING IMMUNODEFICIENCY VIRUS TRANSCRIPTION<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE MODULATION DE LA TRANSCRIPTION DE VIRUS D'IMMUNODÉFICIENCE
  申请人：DAVID GLADSTONE INST

  公开号：WO2012047852A2

  公开（公告）日：2012-04-12

  The present disclosure provides methods of modulating immunodeficiency virus transcription, involving modulating enzymatic activity and/or levels of a lysine-specific demethylase-1 (LSD1) polypeptide and/or LSD1-mediated demethylation of methylated Tat. The present disclosure also provides method of identifying agents that modulate LSD1-mediated demethylation of a human immunodeficiency virus (HIV) Tat polypeptide.
• [EN] HUMAN ENDOGENOUS RETROVIRUS PEPTIDES, ANTIBODIES TO THE PEPTIDES, AND METHODS OF USE THEREOF<br/>[FR] PEPTIDES RÉTROVIRAUX HUMAINS ENDOGÈNES, ANTICORPS ANTI-PEPTIDES, ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV CALIFORNIA

  公开号：WO2013059426A1

  公开（公告）日：2013-04-25

  The present disclosure provides anti-HERV-K antibodies, and compositions comprising the antibodies. An antibody to HERV-K is useful in various therapeutic and diagnostic applications, which are also provided. The present disclosure also provides HERV-K peptides, as well as compositions comprising the peptides. HERV-K peptides of the present disclosure are useful in therapeutic applications, and for generating antibodies.