2-[(Z)-(3-hydroxy-2-phenyl-chromen-4-ylidene)amino]benzoic acid | 1361237-35-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2-[(Z)-(3-hydroxy-2-phenyl-chromen-4-ylidene)amino]benzoic acid
• 英文别名: 2-[(3-hydroxy-2-phenylchromen-4-ylidene)amino]benzoic acid
• CAS: 1361237-35-5
• 化学式: C₂₂H₁₅NO₄
• 分子量: 357.365
• InChiKey: CFYYLRQCCMTJCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  79.1
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-羟基黄酮 、 邻氨基苯甲酸 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以66%的产率得到2-[(Z)-(3-hydroxy-2-phenyl-chromen-4-ylidene)amino]benzoic acid
  参考文献：
  名称：

  Novel metal based anti-tuberculosis agent: Synthesis, characterization, catalytic and pharmacological activities of copper complexes

  摘要：

  Copper complexes of molecular formulae, [CuL1(OAc)], [CuL2(H2O)], [CuL3(H2O)], [CuL4(H2O)], [CuL5(H2O)] where L-1-L-5 represents Schiff base ligands by the condensation of 3-hydroxyflavone with 4-aminoantipyrine (L-1)/o-aminophenol (L-2)/o-aminobenzoic acid (L-3)/o-aminothiazole (L-4)/thio-semicarbazide (L-5)], have been prepared. They were characterized using analytical and spectral techniques. The DNA binding properties of copper complexes were studied using electronic absorption spectra and viscosity measurements. Superoxide dismutase and antioxidant activities of the copper complexes have also been studied. Furthermore, the copper complexes have been found to promote pUC18 DNA cleavage in the presence of oxidant. Anti-tuberculosis activity was also performed. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.01.006