Diethyl 2-[2-(2-methoxyphenyl)-2-oxoethyl]propanedioate | 1248587-22-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Diethyl 2-[2-(2-methoxyphenyl)-2-oxoethyl]propanedioate
• 英文别名: diethyl 2-[2-(2-methoxyphenyl)-2-oxoethyl]propanedioate
• CAS: 1248587-22-5
• 化学式: C₁₆H₂₀O₆
• 分子量: 308.331
• InChiKey: QDHWARVCXBQATA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  78.9
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  α,α-dibromo-2'-methoxyacetophenone 、 丙二酸二乙酯 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 24.25h， 以77%的产率得到Diethyl 2-[2-(2-methoxyphenyl)-2-oxoethyl]propanedioate
  参考文献：
  名称：

  Bromophilic substitution/carbophilic substitution cascade reactions of α,α-dibromo-2-methoxyacetophenone with C-, N- and O-nucleophiles

  摘要：

  alpha,alpha-Dibromo-2-methoxyacetophenone reacts, under mild reaction conditions, with C-, N- and O-nucleophiles via a bromophilic substitution/protonation/carbophilic substitution cascade process to afford alpha-monosubstituted-2-methoxyacetophenones in moderate to good yield. The only exception from this reaction pathway is the reaction with the anion derived from malononitrile in which 2-aroyl-1,1,3,3-tetracyanopropene is obtained. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.07.057

文献信息

• Bromophilic substitution/carbophilic substitution cascade reactions of α,α-dibromo-2-methoxyacetophenone with C-, N- and O-nucleophiles
  作者：Jovana Tatar、Rade Marković、Milovan Stojanović、Marija Baranac-Stojanović

  DOI：10.1016/j.tetlet.2010.07.057

  日期：2010.9

  alpha,alpha-Dibromo-2-methoxyacetophenone reacts, under mild reaction conditions, with C-, N- and O-nucleophiles via a bromophilic substitution/protonation/carbophilic substitution cascade process to afford alpha-monosubstituted-2-methoxyacetophenones in moderate to good yield. The only exception from this reaction pathway is the reaction with the anion derived from malononitrile in which 2-aroyl-1,1,3,3-tetracyanopropene is obtained. (C) 2010 Elsevier Ltd. All rights reserved.