2-phenyl-8H-pyrazolo<5,1-a>isoindol-8-one | 37564-20-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-phenyl-8H-pyrazolo<5,1-a>isoindol-8-one
• 英文别名: 2-Phenyl-8H-pyrazolo<5,1-a>isoindol-8-on；2-phenyl-pyrazolo[5,1-a]isoindol-8-one；2-Phenylpyrazolo[1,5-b]isoindol-5-one
• CAS: 37564-20-8
• 化学式: C₁₆H₁₀N₂O
• 分子量: 246.268
• InChiKey: RAEVCHOLXVNVSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  34.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-phenyl-8H-pyrazolo<5,1-a>isoindol-8-one 以50%的产率得到
  参考文献：
  名称：

  JOHNSON A. L.; SWEETSER P. B., J. ORG. CHEM. , 1976, 41, NO 1, 110-114

  摘要：

  DOI：
• 作为产物：
  描述：

  2-phenyl-3,3a-dihydropyrazolo[5,1-a]isoindol-8-one 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 苯 为溶剂， 反应 1.0h， 以84%的产率得到2-phenyl-8H-pyrazolo<5,1-a>isoindol-8-one
  参考文献：
  名称：

  锡粉促级联缩合反应合成1-(3H)异苯并呋喃酮类化合物

  摘要：

  通过锡粉介导的 2-甲酰基苯甲酸与烯丙基溴或α-溴酮在温和反应条件下的级联缩合反应，开发了一种有效的邻苯二甲酸酯化合物构建方法。该方法操作简单，可以耐受各种官能团，从而以良好到极好的收率得到相应的邻苯二甲酸酯。由α-溴酮生产的邻苯二甲酸酯可进一步转化为3,3a -dihydro -8 H -pyrazolo [5, l - a ]isoindol-8-one和8 H -pyrazolo[5, l- a ]isoindol-8-一。

  DOI：

  10.1002/aoc.6249

文献信息

• COMPOSITIONS, METHODS, AND PLANT GENES FOR THE IMPROVED PRODUCTION OF FERMENTABLE SUGARS FOR BIOFUEL PRODUCTION
  申请人：The Governing Council of the University of Toronto

  公开号：US20150044678A1

  公开（公告）日：2015-02-12

  Described herein are compositions comprising at least one auxin transport inhibitor for pre-treating a plant or seed to increase saccharification, or saccharide release by hydrolysis, the at least one auxin transport inhibitor being in an amount effective to increase sugar release from a plant tissue by hydrolysis. Also described are plant mutations, and methods to screen for such plant mutations, having an improved sugar release phenotype. The described compositions, methods and plant mutations are particularly useful for producing biofuel crops, such as maize, to improve sugar extractability from lignocellulosic biomass and hence, the efficiency of bioethanol production overall.
• US9856512B2
  申请人：——

  公开号：US9856512B2

  公开（公告）日：2018-01-02
• [EN] COMPOSITIONS, METHODS, AND PLANT GENES FOR THE IMPROVED PRODUCTION OF FERMENTABLE SUGARS FOR BIOFUEL PRODUCTION<br/>[FR] COMPOSITIONS, PROCÉDÉS ET GÈNES DE PLANTES POUR UNE MEILLEURE PRODUCTION DE SUCRES FERMENTABLES DESTINÉS À LA PRODUCTION DE BIOCARBURANT
  申请人：UNIV TORONTO

  公开号：WO2013142968A1

  公开（公告）日：2013-10-03

  Described herein are compositions comprising at least one auxin transport inhibitor for pre-treating a plant or seed to increase saccharification, or saccharide release by hydrolysis, the at least one auxin transport inhibitor being in an amount effective to increase sugar release from a plant tissue by hydrolysis. Also described are plant mutations, and methods to screen for such plant mutations, having an improved sugar release phenotype. The described compositions, methods and plant mutations are particularly useful for producing biofuel crops, such as maize, to improve sugar extractability from lignocellulosic biomass and hence, the efficiency of bioethanol production overall.