6,7,8,9-tetraidro-5H-benzocicloept-5,6-dione | 97705-32-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6,7,8,9-tetraidro-5H-benzocicloept-5,6-dione
• 英文别名: 8,9-Dihydro-5H,7H-benzocyclohepta-5,6-dione；8,9-dihydro-7H-benzocycloheptene-5,6-dione；8,9-Dihydro-7H-benzocyclohepten-5,6-dion；6,7,8,9-tetrahydro-5H-benzo-cycloheptene-5,6-dione；6,7,8,9-tetrahydro-5H-benzocycloheptene-5,6-dione；1,2-Benzo-cyclohepten-(1)-dion；8,9-dihydro-7H-benzo[7]annulene-5,6-dione
• CAS: 97705-32-3
• 化学式: C₁₁H₁₀O₂
• 分子量: 174.199
• InChiKey: VCORJVHHVZXWQX-UHFFFAOYSA-N

物化性质

• 熔点：
  55 °C
• 沸点：
  128-132 °C(Press: 0.4 Torr)
• 密度：
  1.185±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6,7,8,9-tetraidro-5H-benzocicloept-5,6-dione 在 palladium on activated charcoal 、 溴 、 三氯苯 作用下， 生成 7-Brom-3,4-benzotropolon
  参考文献：
  名称：

  Cook et al., Journal of the Chemical Society, 1952, p. 607,610

  摘要：

  DOI：
• 作为产物：
  描述：

  6,7,8,9-tetrahydro-5H-benzocycloheptene-5,6-dione oxime 在 盐酸 、 sodium hydrogensulfite 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 生成 6,7,8,9-tetraidro-5H-benzocicloept-5,6-dione
  参考文献：
  名称：

  Fused polycyclic compounds, compositions, methods of manufacture, and their use as PAF antagonists, antihistamines and/or antiinflammatory agents

  摘要：

  公开号：

  EP0339978B1

文献信息

• Synthesis of 3 : 4-Benztropolone
  作者：J. W. COOK、A. R. SOMERVILLE

  DOI：10.1038/163410a0

  日期：1949.3

  DEWAR1 has interpreted the chemistry of the mould metabolite, stipitatic acid, and of colchiceine (the methyl ether of which is the alkaloid colchicine) by postulating that they are derived from the hypothetical cycloheptatrienolone (I). This he termed 'tropolone', and he attributed to it quasi-aromatic character. This interesting suggestion, for which no tangible evidence was advanced2, has acquired more plausibility from the recent demonstration of Haworth, Moore and Pauson3 that purpurogallin is a trihydroxybenztropolone, as earlier suggested by Barltrop and Nicholson4, and from the finding of Erdtman and Gripenberg5 that the cedar-wood constituent γ-thujaplicin is an isopropyltropolone. Hitherto, a synthetic tropolone of established constitution has not been prepared, and the properties ascribed to such a structure have been based largely on speculation.

  DEWAR1 通过假设拟环-七烯酮（I）是霉菌代谢物斯蒂皮酸和秋水仙碱（其甲基醚为生物碱秋水仙碱）的来源，解释了它们的化学特性。他称之为“特罗波烯”，并赋予其准芳香性。这一有趣的建议，虽然没有提出实际证据2，但因最近Haworth、Moore和Pauson3的研究表明紫褐酚是一种三羟基苯特罗波烯而获得了更多的可信度，早前Barltrop和Nicholson4也有类似的推测。此外，Erdtman和Gripenberg5发现的雪松木成分γ-桧木酚是一种异丙基特罗波烯。迄今为止，尚未制备出具有确定结构的合成特罗波烯，而归因于这种结构的性质主要是基于推测。
• 1,2-disubstituted 1,4-dihydro-4-oxoquinoline compounds
  申请人：Maruishi Pharmaceutical Co., Ltd.

  公开号：EP1380575A1

  公开（公告）日：2004-01-14

  The present invention relates to substituted 1,4-dihydro-4-oxoquinolines having antiviral activity. The substituents are present at positions 1, 2 and at least one of 5-8 positions of the quinoline ring.

  本发明涉及具有抗病毒活性的取代1,4-二氢-4-氧喹啉。取代基出现在喹啉环的1、2位置和至少5-8位置之一。
• Bianchi; Butti; Pfeiffer, Farmaco, Edizione Scientifica, 1986, vol. 41, # 3, p. 229 - 256
  作者：Bianchi、Butti、Pfeiffer、et al.

  DOI：——

  日期：——
• Anderson, Arthur G.; Richards, Harry F., Organic Preparations and Procedures International, 1992, vol. 24, # 5, p. 543 - 546
  作者：Anderson, Arthur G.、Richards, Harry F.

  DOI：——

  日期：——
• Moroe et al., Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1952, vol. 72, p. 1238
  作者：Moroe et al.

  DOI：——

  日期：——