1,1’-(1,4-phenylene)bis(3-(4-methoxyphenyl)prop-2-en-1-one) | 132843-76-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1,1’-(1,4-phenylene)bis(3-(4-methoxyphenyl)prop-2-en-1-one)
• 英文别名: (2E,2′E)-1,1′-(1,4-phenylene)bis(3-(4-methoxyphenyl)prop-2-en-1-one)；(E)-3-(4-methoxyphenyl)-1-[4-[(E)-3-(4-methoxyphenyl)prop-2-enoyl]phenyl]prop-2-en-1-one
• CAS: 132843-76-6
• 化学式: C₂₆H₂₂O₄
• 分子量: 398.458
• InChiKey: NRBBYUYQYCOUDZ-ZEELXFFVSA-N

物化性质

• 沸点：
  614.2±55.0 °C(Predicted)
• 密度：
  1.178±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,1’-(1,4-phenylene)bis(3-(4-methoxyphenyl)prop-2-en-1-one) 在 吡啶 、 盐酸 、 三乙胺 作用下， 以 乙醚 、 氯仿 为溶剂， 反应 51.0h， 生成 {4-[1-Benzenesulfonyl-4-(4-methoxy-phenyl)-4,5-dihydro-1H-pyrazole-3-carbonyl]-phenyl}-[1-benzenesulfonyl-4-(4-methoxy-phenyl)-4,5-dihydro-1H-pyrazol-3-yl]-methanone
  参考文献：
  名称：

  Reddy; Seshamma; Seenaiah, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1991, vol. 30, # 1, p. 46 - 51

  摘要：

  DOI：
• 作为产物：
  描述：

  1,4-二乙酰苯 、 4-甲氧基苯甲醛 在 sodium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 反应 0.25h， 以91%的产率得到1,1’-(1,4-phenylene)bis(3-(4-methoxyphenyl)prop-2-en-1-one)
  参考文献：
  名称：

  Synthesis, characterization and antimicrobial activities of some novel bis-chalcones

  摘要：

  A series of novel bis-chalcones 3a-n were synthesized in excellent yields by condensation reaction of 1,4-diacetylbenzene with various aldehydes in ethanol 96% and aqueous NaOH at room temperature. All compounds were characterized by IR, H-1 and C-13 NMR, UV spectroscopy and elemental analysis. The antimicrobial activities of synthesized compounds were also evaluated. The most of these compounds exhibited a good activity against Staphylococcus aureus, Escherichia coli and Candida albicans microorganisms. Some of them showed significant activities.

  DOI：

  10.1007/s00044-011-9696-z

文献信息

• Synthesis of Some New Bis[1-(2-aroyl-3-aryl)cyclopropylcarbonyl]benzenes and Pyridines under Phase Transfer Catalysis (PTC) Method
  作者：Dandu Bhaskar Reddy、Biradavolu Seenaiah、Adivireddi Padmaja、Pallela Venkata Ramana Reddy

  DOI：10.1135/cccc19931437

  日期：——

  Some new bis[1-(2-aroyl-3-aryl)cyclopropylcarbonyl]benzenes and pyridines IV - VI have been prepared by the cycloaddition of dimethylsulfonium phenacylide to 1,1'-(1,3-, 1,4-phenylene, and 2,6-pyridylene)-bis(3-aryl-2-propen-1-ones) I - III by adopting two different methods. The advantages of the PTC method over the other have been discussed. The structures of the compound have been confirmed by spectral data.

  一些新的双[1-(2-芳酰基-3-芳基)环丙基羰基]苯和吡啶已通过将二甲基亚砜苯乙炔与1,1'-(1,3-, 1,4-苯基和2,6-吡啶基)-双(3-芳基-2-丙烯-1-酮)进行环加成反应而制备，采用了两种不同的方法。讨论了PTC方法相对于其他方法的优势。该化合物的结构已通过光谱数据确认。
• Reddy, D. Bhaskar; Seenaiah, B.; Padmavathi, V., Phosphorus, Sulfur and Silicon and the Related Elements, 1992, vol. 69, # 1-2, p. 31 - 42
  作者：Reddy, D. Bhaskar、Seenaiah, B.、Padmavathi, V.、Seshamma, T.

  DOI：——

  日期：——
• Bhaskar Reddy; Seenaiah; Muralidhar Reddy, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996, vol. 35, # 10, p. 1012 - 1016
  作者：Bhaskar Reddy、Seenaiah、Muralidhar Reddy

  DOI：——

  日期：——
• Synthesis, characterization and antimicrobial activities of some novel bis-chalcones
  作者：Akbar Mobinikhaledi、Mehdi Kalhor、Hossein Jamalifar

  DOI：10.1007/s00044-011-9696-z

  日期：2012.8

  A series of novel bis-chalcones 3a-n were synthesized in excellent yields by condensation reaction of 1,4-diacetylbenzene with various aldehydes in ethanol 96% and aqueous NaOH at room temperature. All compounds were characterized by IR, H-1 and C-13 NMR, UV spectroscopy and elemental analysis. The antimicrobial activities of synthesized compounds were also evaluated. The most of these compounds exhibited a good activity against Staphylococcus aureus, Escherichia coli and Candida albicans microorganisms. Some of them showed significant activities.
• UMA, DEVI Y.;ASHOK, K.;RAO, K. R. K. M., INDIAN J. CHEM. B, 29,(1990) N, C. 898-900
  作者：UMA, DEVI Y.、ASHOK, K.、RAO, K. R. K. M.

  DOI：——

  日期：——