2-O-alpha-D-吡喃葡萄糖基-D-葡萄糖 | 37169-66-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-O-alpha-D-吡喃葡萄糖基-D-葡萄糖
• 英文名称: α-D-glucopyranosyl-(1→2)-α-D-glucopyranose
• 英文别名: α-D-Glc p-(1->2)-α-D-Glc；α-D-Glcp-(1->2)-D-Glcp；α-kojibiose；kojibiose；O²-α-D-Glucopyranosyl-α-D-glucopyranose；2-O-alpha-D-Glucopyranosyl-alpha-D-glucose；(2S,3R,4S,5S,6R)-6-(hydroxymethyl)-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-2,4,5-triol
• CAS: 37169-66-7
• 化学式: C₁₂H₂₂O₁₁
• 分子量: 342.3
• InChiKey: HIWPGCMGAMJNRG-LFWCVFAXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.2
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  190
• 氢给体数：
  8
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  2-O-alpha-D-吡喃葡萄糖基-D-葡萄糖 在 Streptococcus mutans dextran glucosidase 、 bovine serum albumin 作用下， 以 aq. acetate buffer 为溶剂， 反应 0.17h， 生成 a-无水葡萄糖酯
  参考文献：
  名称：

  Structural elements responsible for the glucosidic linkage‐selectivity of a glycoside hydrolase family 13 exo‐glucosidase

  摘要：

  Glycoside hydrolase family 13 contains exo‐glucosidases specific for α‐(1 → 4)‐ and α‐(1 → 6)‐linkages including α‐glucosidase, oligo‐1,6‐glucosidase, and dextran glucosidase. The α‐(1 → 6)‐linkage selectivity of Streptococcus mutans dextran glucosidase was altered to α‐(1 → 4)‐linkage selectivity through site‐directed mutations at Val195, Lys275, and Glu371. V195A showed 1300‐fold higher k cat/K m for maltose than wild‐type, but its k cat/K m for isomaltose remained 2‐fold higher than for maltose. K275A and E371A combined with V195A mutation only decreased isomaltase activity. V195A/K275A, V195A/E371A, and V195A/K275A/E371A showed 27‐, 26‐, and 73‐fold higher k cat/K m for maltose than for isomaltose, respectively. Consequently, the three residues are structural elements for recognition of the α‐(1 → 6)‐glucosidic linkage.

  DOI：

  10.1016/j.febslet.2015.02.023
• 作为产物：
  描述：

  kojitriose α-anomer 在 盐酸 作用下， 以 水 为溶剂， 反应 1.5h， 生成 D-葡萄糖 、 2-O-alpha-D-吡喃葡萄糖基-D-葡萄糖
  参考文献：
  名称：

  Acetolysis of Leuconostoc mesenteroides NRRL B-1299 dextran. Isolation and characterization of oligosaccharides containing secondary linkages from the borate-soluble fraction

  摘要：

  Fractionation of the deacetylated acetolyzate of the borate-soluble fraction of the dextran elaborated by L. mesenteroides NRRL B-1299 gave, after chromatography on charcoal-Celite, preparative paper-chromatography, and paper electrophoresis, 4 trisaccharide fractions and 4-tetrasaccharide fractions. The isolated oligosaccharides were characterized by their paper-chromatographic mobility, examination of partial acid-hydrolyzates of the oligosaccharides and their corresponding alditols, and methylation analysis. These oligosaccharides were kojitriose, isomaltotriose, a mixture of 2-O-.alpha.-isomaltosyl-D-glucose, 21-O-.alpha.-D-glucosylisomaltose and 2-O-.alpha.-nigerosyl-D-glucose, 6-O-.alpha.-kojibiosyl-D-glucose, isomaltotetraose, a mixture of 2-O-.alpha.-isomaltotriosyl-D-glucose and 21-O-.alpha.-D-glucosylisomaltotriose, 6-O-.alpha.-kojitriosyl-D-glucose and 63-O-.alpha.-D-glucosylkojitriose, respectively. Some of these oligosaccharides are newly isolated and characterized.

  DOI：

  10.1016/s0008-6215(00)85371-9

文献信息

• [EN] NATURAL AND SYNTHETIC DITERPENE GLYCOSIDES, COMPOSITIONS AND METHODS<br/>[FR] GLYCOSIDES DITERPÉNIQUES NATURELS ET SYNTHÉTIQUES, COMPOSITIONS ET PROCÉDÉS
  申请人：COCA COLA CO

  公开号：WO2019147617A1

  公开（公告）日：2019-08-01

  Novel diterpene glycosides isolated from Stevia extract as well as diterpene glycosides that are synthetically prepared are provided herein. Compositions and consumables comprising the novel diterpene glycosides are also provided herein. Methods of enhancing the sweetness and/or flavor of consumables using the novel diterpene glycosides, methods of preparing compositions and consumables comprising the novel diterpene glycosides, methods of purifying the novel diterpene glycosides and methods of synthesizing the diterpene glycosides are also provided.

  本文提供了从甜菊提取物中分离出的新型二萜苷和合成制备的二萜苷。本文还提供了包含这些新型二萜苷的组合物和消费品。还提供了使用这些新型二萜苷增强消费品的甜味和/或风味的方法，制备包含这些新型二萜苷的组合物和消费品的方法，纯化这些新型二萜苷的方法以及合成二萜苷的方法。
• Neue Aminozucker-Derivate, ihre Herstellung und Amylase-hemmende Mittel
  申请人：F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft

  公开号：EP0003616A2

  公开（公告）日：1979-08-22

  Neue Aminozucker-Derivate mit Trehalose als gemeinsamem Strukturmerkmal erhält man aus Kulturen von Streptomyces, besonders S. dimorphogenes ATCC-No. 31484 und ATCC-No. 31485. Die neuen Aminozucker-Derivate hemmen Amylase.

  从链霉菌（尤其是二变形链霉菌 ATCC-No. 31484 和 ATCC-No. 31485）的培养物中获得了以三卤糖为共同结构特征的新型氨基糖衍生物。
• Verfahren zur Erhöhung der Leistungsfähigkeit Aminosäuren ausscheidender Bakterien
  申请人：Degussa Aktiengesellschaft

  公开号：EP0537443A1

  公开（公告）日：1993-04-21

  Die Erfindung betrifft ein Verfahren zur Erhöhung der Leistungsfähigkeit Aminosäuren ausscheidender Stämme coryneformer Bakterien, bei dem man bei diesen Stämmen die Fähigkeit zum Wachstum auf Trehalose induziert, und die Mutanten auf Trehalose-haltigen Medien selektioniert.

  本发明涉及一种提高分泌氨基酸的伞菌菌株效率的工艺，在该工艺中，诱导这些菌株在妥哈糖上生长的能力，并在含妥哈糖的培养基上筛选突变体。
• Nucleic acid amplification method and apparatus
  申请人：Becton Dickinson and Company

  公开号：EP0674009A2

  公开（公告）日：1995-09-27

  The present invention relates to an apparatus for performing a biological process and is particularly useful for processes which include amplicon decontamination and nucleic acid amplification steps. The apparatus includes a sample well for introduction and removal of a liquid biological sample, at least one reaction chamber containing dried reagents in fluid communication with the sample well, a pneumatic chamber in pneumatic communication with the reaction chamber and sample well, and a pneumatic port in the pneumatic chamber for connection of the apparatus to a pneumatic aspiration/dispensing means which causes the flow of the liquid sample within the apparatus.

  本发明涉及一种用于执行生物过程的装置，特别适用于包括扩增子净化和核酸扩增步骤的过程。该装置包括一个用于引入和移出液体生物样品的样品井，至少一个与样品井流体相通的装有干燥试剂的反应室，一个与反应室和样品井气动相通的气动室，以及气动室中用于将该装置与气动抽吸/分配装置连接的气动端口，气动抽吸/分配装置可使液体样品在装置内流动。
• Sucrose phosphorylase for the production of kojibiose
  申请人：Universiteit Gent

  公开号：US10435729B2

  公开（公告）日：2019-10-08

  The present invention relates to the production of the disaccharide kojibiose which is known to be a powerful prebiotic. The invention indeed discloses the generation of genetically modified sucrose phosphorylases which convert—via a transglycosylation reaction—sucrose into kojibiose in a very efficient manner. Hence, the present invention relates to a cost-effective production method of kojibiose which is useful within industry.

  本发明涉及生产众所周知的强效益生元--芋螺二糖。事实上，本发明公开了转基因蔗糖磷酸化酶的产生过程，这种酶通过转糖基化反应将蔗糖非常有效地转化成柯西比糖。因此，本发明涉及一种在工业中有用的、具有成本效益的柯西比糖生产方法。