2-[5-(4-methoxy-phenyl)-2-phenyl-1H-imidazol-4-yl]-ethylamine | 848949-69-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-[5-(4-methoxy-phenyl)-2-phenyl-1H-imidazol-4-yl]-ethylamine
• 英文别名: 2-[4-(4-methoxyphenyl)-2-phenyl-1H-imidazol-5-yl]ethanamine
• CAS: 848949-69-9
• 化学式: C₁₈H₁₉N₃O
• 分子量: 293.368
• InChiKey: YBMOHGHIZDLQHN-UHFFFAOYSA-N

物化性质

• 沸点：
  556.3±50.0 °C(Predicted)
• 密度：
  1.163±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  63.9
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-[5-(4-methoxy-phenyl)-2-phenyl-1H-imidazol-4-yl]-ethylamine 、 对甲苯异硫氰酸酯 以 乙腈 为溶剂， 反应 60.0h， 以84%的产率得到1-{2-[5-(4-Methoxy-phenyl)-2-phenyl-1H-imidazol-4-yl]-ethyl}-3-p-tolyl-thiourea
  参考文献：
  名称：

  Imidazolyl inhibitors of 15-lipoxygenase

  摘要：

  本发明提供了15-LO的咪唑基抑制剂，包含这些抑制剂的药物组合物以及使用这些化合物和组合物治疗与15-LO级联相关疾病的方法。

  公开号：

  US20050070588A1
• 作为产物：
  描述：

  4-(2-azido-ethyl)-5-(4-methoxy-phenyl)-2-phenyl-1H-imidazole 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 以100%的产率得到2-[5-(4-methoxy-phenyl)-2-phenyl-1H-imidazol-4-yl]-ethylamine
  参考文献：
  名称：

  Discovery of selective imidazole-based inhibitors of mammalian 15-lipoxygenase: Highly potent against human enzyme within a cellular environment

  摘要：

  A series of 2,4,5-tri-substituted imidazoles has proven to be highly potent in inhibiting mammalian 15-lipoxygenase (15LO) with excellent selectivity over human isozymes 5- and P-12-LO. Non-symmetrical sulfamides (e.g., 21a-n) were found to be suitable replacements for the earlier arylsulfonamide-containing members of this series (e.g., 2, 14a-p). Several members of these series also demonstrated potent inhibition of human 15-LO in a cell-based assay. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.07.011

文献信息

• US7317032B2
  申请人：——

  公开号：US7317032B2

  公开（公告）日：2008-01-08
• Discovery of selective imidazole-based inhibitors of mammalian 15-lipoxygenase: Highly potent against human enzyme within a cellular environment
  作者：David S. Weinstein、Wen Liu、Khehyong Ngu、Charles Langevine、Donald W. Combs、Shaobin Zhuang、Cindy Chen、Cort S. Madsen、Timothy W. Harper、Jeffrey A. Robl

  DOI：10.1016/j.bmcl.2007.07.011

  日期：2007.9

  A series of 2,4,5-tri-substituted imidazoles has proven to be highly potent in inhibiting mammalian 15-lipoxygenase (15LO) with excellent selectivity over human isozymes 5- and P-12-LO. Non-symmetrical sulfamides (e.g., 21a-n) were found to be suitable replacements for the earlier arylsulfonamide-containing members of this series (e.g., 2, 14a-p). Several members of these series also demonstrated potent inhibition of human 15-LO in a cell-based assay. (c) 2007 Elsevier Ltd. All rights reserved.
• Imidazolyl inhibitors of 15-lipoxygenase
  申请人：Weinstein S. David

  公开号：US20050070588A1

  公开（公告）日：2005-03-31

  The present invention provides imidazolyl inhibitors of 15-LO, pharmaceutical compositions containing such inhibitors and methods for treating diseases related to the 15-LO cascade using such compounds and compositions.

  本发明提供了15-LO的咪唑基抑制剂，包含这些抑制剂的药物组合物以及使用这些化合物和组合物治疗与15-LO级联相关疾病的方法。