(E)-1-(2-methoxyphenyl)-3-(p-tolyl)prop-2-en-1-one | 141885-67-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (E)-1-(2-methoxyphenyl)-3-(p-tolyl)prop-2-en-1-one
• 英文别名: (2E)-1-(2-Methoxyphenyl)-3-(4-methylphenyl)prop-2-en-1-one；(E)-1-(2-methoxyphenyl)-3-(4-methylphenyl)prop-2-en-1-one
• CAS: 141885-67-8
• 化学式: C₁₇H₁₆O₂
• 分子量: 252.313
• InChiKey: YNOZRTZOCFOXDS-VAWYXSNFSA-N

物化性质

• 沸点：
  413.3±45.0 °C(Predicted)
• 密度：
  1.096±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (E)-1-(2-methoxyphenyl)-3-(p-tolyl)prop-2-en-1-one 在 三乙胺 、 lithium chloride 作用下， 以 N,N-二甲基甲酰胺 、 苯 为溶剂， 反应 12.0h， 生成 (2,5-Diphenyl-4-p-tolyl-2H-pyrazol-3-yl)-(2-methoxy-phenyl)-methanone
  参考文献：
  名称：

  M'Sadek, Moncef; Rammah, Mohammed; Schmitt, Gerard, Bulletin des Societes Chimiques Belges, 1992, vol. 101, # 4, p. 323 - 328

  摘要：

  DOI：
• 作为产物：
  描述：

  2'-甲氧基苯乙酮 在 吡啶 、 selenium(IV) oxide 、 dipotassium peroxodisulfate 、 silver carbonate 作用下， 以 乙腈 为溶剂， 反应 29.0h， 生成 (E)-1-(2-methoxyphenyl)-3-(p-tolyl)prop-2-en-1-one
  参考文献：
  名称：

  Silver-catalyzed decarboxylative cross-coupling of α-keto acids with alkenes giving approach to chalcones

  摘要：

  A silver-catalyzed decarboxylative cross-coupling of alpha-keto acids with alkenes is reported. The method, with a wide range of substrate tolerance and mild operational conditions, can produce various chalcone derivatives in moderate to high yields from easily available starting materials. (C) 2017 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2017.11.005

文献信息

• Rh(III)-Catalyzed Enone Carbonyl/Ketone-Directed Aerobic C–H Olefination of Aromatics with Unactivated Olefins
  作者：Chikkabagilu Nagaraju Shambhavi、Masilamani Jeganmohan

  DOI：10.1021/acs.joc.2c01730

  日期：2022.10.7

  carbonyl/ketone-assisted aerobic oxidative C–H olefination of aromatics with unactivated alkenes has been developed. This protocol involves cross-dehydrogenative Heck-type olefination reaction of various substituted biologically relevant chalcones and aromatic ketones such as acetophenones and chromones with various functionalized unactivated olefins in moderate to good yields. Further, ortho-alkylation of chalcones

  已经开发了一种 Rh(III) 催化的弱烯酮羰基/酮辅助的芳烃与未活化烯烃的好氧氧化 C-H 烯化。该协议涉及各种取代的生物相关查尔酮和芳香酮（如苯乙酮和色酮）与各种功能化未活化烯烃的交叉脱氢 Heck 型烯化反应，产率适中至良好。此外，还证明了查尔酮与降冰片烯的邻位烷基化。氘标记研究提出并支持了一种可能的反应机制，涉及弱螯合辅助的 C-H 活化/插入/β-氢化物消除。
• CHALCONE DERIVATIVES AS NRF2 ACTIVATORS
  申请人：Biswal Shyam

  公开号：US20140088052A1

  公开（公告）日：2014-03-27

  Compounds and methods for treating or preventing a disease, disorder or condition associated with an Nrf2-regulated pathway, including those associated with an autoimmune disease, comorbidity associated with diabetes, such as retinopathy and nephropathy, bone marrow transplant for leukemia and related cancers, bone marrow deficiencies, inborn errors of metabolism, and other immune disorders, oxidative stress, respiratory infection, ischemia, neurodegenerative disorders, radiation injury, neutropenia caused by chemotherapy, autoimmunity, and congenital neutropenic disorders, and for restoring a corticosteroid responsiveness, in a subject are provided.
• Silver-catalyzed decarboxylative cross-coupling of α-keto acids with alkenes giving approach to chalcones
  作者：Shang Wu、Hongheng Yu、Qinzheng Hu、Quanlu Yang、Shouwang Xu、Tian Liu

  DOI：10.1016/j.tetlet.2017.11.005

  日期：2017.12

  A silver-catalyzed decarboxylative cross-coupling of alpha-keto acids with alkenes is reported. The method, with a wide range of substrate tolerance and mild operational conditions, can produce various chalcone derivatives in moderate to high yields from easily available starting materials. (C) 2017 Elsevier Ltd. All rights reserved.
• M'Sadek, Moncef; Rammah, Mohammed; Schmitt, Gerard, Bulletin des Societes Chimiques Belges, 1992, vol. 101, # 4, p. 323 - 328
  作者：M'Sadek, Moncef、Rammah, Mohammed、Schmitt, Gerard、Vebrel, Joel

  DOI：——

  日期：——