5-(3-Methylbut-2-en-2-yl)-2-propyl-1,3-thiazole | 1029129-51-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(3-Methylbut-2-en-2-yl)-2-propyl-1,3-thiazole
• 英文别名: 5-(3-methylbut-2-en-2-yl)-2-propyl-1,3-thiazole
• CAS: 1029129-51-8
• 化学式: C₁₁H₁₇NS
• 分子量: 195.329
• InChiKey: PMLJQUQEGZKAHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  41.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-正丙基噻唑 、 2-溴-3-甲基-2-丁烯 在 PdCl(C₃H₅)(dppb) caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以36%的产率得到5-(3-Methylbut-2-en-2-yl)-2-propyl-1,3-thiazole
  参考文献：
  名称：

  Alkenyl bromides: useful coupling partners for the palladium-catalysed coupling with heteroaromatics via a C–H bond activation

  摘要：

  Alkenyl bromides were found to be useful reactants for the palladium-catalysed direct C-H activation/functionalisation reaction of heteroaromatics such as benzoxazole or benzothiazole. Moderate to good yields of coupling products were obtained using both alpha- and P-substituted alkenyl bromides or even the trisubstituted alkenyl bromide 2-bromo-3-methylbut-2-ene. This reaction is environmentally attractive as it provides only HX associated to the base as a by-product. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.03.020

文献信息

• Alkenyl bromides: useful coupling partners for the palladium-catalysed coupling with heteroaromatics via a C–H bond activation
  作者：Aditya L. Gottumukkala、Fazia Derridj、Safia Djebbar、Henri Doucet

  DOI：10.1016/j.tetlet.2008.03.020

  日期：2008.4

  Alkenyl bromides were found to be useful reactants for the palladium-catalysed direct C-H activation/functionalisation reaction of heteroaromatics such as benzoxazole or benzothiazole. Moderate to good yields of coupling products were obtained using both alpha- and P-substituted alkenyl bromides or even the trisubstituted alkenyl bromide 2-bromo-3-methylbut-2-ene. This reaction is environmentally attractive as it provides only HX associated to the base as a by-product. (c) 2008 Elsevier Ltd. All rights reserved.